Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Robert J, Alpern"'
A classic nephrology reference for over 25years, Seldin and Giebisch's The Kidney, is the acknowledged authority on renal physiology and pathophysiology. In this 5th edition, such new and powerful disciplines as genetics and cell biology have been de
Autor:
Robert J. Alpern, Steven C. Hebert
A classic nephrology reference for over 20 years, Seldin & Giebisch's The Kidney, is the acknowledged authority on renal physiology and pathophysiology. The fourth edition follows the changed focus of nephrology research to the study of how individua
Autor:
Claire Lockey, Robert J. Alpern, Yuri Stasiv, Jerry M. Buysse, Thomas H. Hostetter, Angela Lee, David A. Bushinsky, Elizabeth Li, Gerrit Klaerner, Sarah McNulty, Dawn Parsell, Vandana Mathur
Publikováno v:
Clinical Journal of the American Society of Nephrology. 13:26-35
Background and objectives Metabolic acidosis is common in patients with CKD and has significant adverse effects on kidney, muscle, and bone. We tested the efficacy and safety of TRC101, a novel, sodium-free, nonabsorbed hydrochloric acid binder, to i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0fabeaf8c3ecf8fb6bd29daf46477a
https://doi.org/10.2215/cjn.07300717
https://doi.org/10.2215/cjn.07300717
Autor:
Gerhard Giebisch, Robert J. Alpern
[][1] On April 25, 2018, Dr. Donald Seldin passed away at the age of 97, and the world lost a great treasure. Born in Coney Island, Brooklyn, Seldin attended James Madison High School and established his intellectual roots early on. He then attended
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d079f08ac8ac535990e916e22e009a
https://europepmc.org/articles/PMC6065072/
https://europepmc.org/articles/PMC6065072/
Background Urine citrate is reabsorbed exclusively along the renal proximal tubule via the apical Na+-dicarboxylate cotransporter NaDC-1. We previously showed that an acid load in vivo and media acidification in vitro increase NaDC-1 activity through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c542c0f196d150815397183560e99ac9
http://hdl.handle.net/11591/392151
http://hdl.handle.net/11591/392151
Autor:
Charles Y C, Pak, Khashayar, Sakhaee, Orson W, Moe, John, Poindexter, Beverley, Adams-Huet, Margaret S, Pearle, Joseph E, Zerwekh, Glenn M, Preminger, Michael R, Wills, Neil A, Breslau, Fredric C, Bartter, D C, Brater, Howard J, Heller, Clarita V, Odvina, Cindy L, Wabner, John S, Fordtran, Man, Oh, Abhimanyu, Garg, Jean A, Harvey, Robert J, Alpern, William H, Snyder, Paul C, Peters
Publikováno v:
Kidney International. 80:777-782
The classic definition of hypercalciuria, an upper normal limit of 200 mg/day, is based on a constant diet restricted in calcium, sodium, and animal protein; however, random diet data challenge this. Here our retrospective study determined the validi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52cb1a080ea34e34cd584c24d7b4b0d5
https://doi.org/10.1038/ki.2011.227
https://doi.org/10.1038/ki.2011.227
Autor:
Aldo J. Peixoto, Robert J. Alpern
Publikováno v:
JAMA Internal Medicine. 178:1690
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::060120231443de1ac13f3406185e3325
https://doi.org/10.1001/jamainternmed.2018.4757
https://doi.org/10.1001/jamainternmed.2018.4757
Publikováno v:
American Journal of Physiology-Renal Physiology. 293:F1054-F1064
Exposure to an acid load increases apical membrane Na+/H+ antiporter (NHE3) activity, a process that involves exocytic trafficking of the transporter to the apical membrane. We have previously shown that an intact microfilament structure is required
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e2e0fd04c21144b988b866fd60c6b7a
https://doi.org/10.1152/ajprenal.00295.2007
https://doi.org/10.1152/ajprenal.00295.2007
Autor:
J. Larry Jameson, Nancy C. Andrews, Pamela B. Davis, Arthur S. Levine, J. Gregory Fitz, Robert N. Golden, Larry Shapiro, Kenneth S. Polonsky, Allen M. Spiegel, Jeffrey R. Balser, Karen H. Antman, Vivian S. Lee, Robert J. Alpern, Jeremy M Berg, Lee Goldman, E. Albert Reece, Marsha D. Rappley, Paul B. Rothman, Debra A. Schwinn
Publikováno v:
Science Translational Medicine. 7
Reductions in federal support and clinical revenue jeopardize biomedical research and, in turn, clinical medicine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9313ab59e676ba524684b5f92802806
https://doi.org/10.1126/scitranslmed.aac5200
https://doi.org/10.1126/scitranslmed.aac5200
Publikováno v:
American Journal of Physiology-Renal Physiology. 288:F732-F739
Endothelin-1 (ET-1) increases the activity of Na+/H+exchanger 3 (NHE3), the major proximal tubule apical membrane Na+/H+antiporter. This effect is seen in opossum kidney (OKP) cells expressing the endothelin-B (ETB) and not in cells expressing the en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10da00d88af67d70742e3b02850996c1
https://doi.org/10.1152/ajprenal.00300.2004
https://doi.org/10.1152/ajprenal.00300.2004