Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Robert I. Horne"'
Autor:
Muntasir Kamal, Jessica Knox, Robert I. Horne, Om Shanker Tiwari, Andrew R. Burns, Duhyun Han, Davide Levy, Dana Laor Bar-Yosef, Ehud Gazit, Michele Vendruscolo, Peter J. Roy
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Amyloids are associated with over 50 human diseases and have inspired significant effort to identify small molecule remedies. Here, we present an in vivo platform that efficiently yields small molecule inhibitors of amyloid formation. We pre
Externí odkaz:
https://doaj.org/article/32f38f45c042472bbab5c90925875d7e
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Parkinson’s disease is characterised by the deposition in the brain of amyloid aggregates of α-synuclein. The surfaces of these amyloid aggregates can catalyse the formation of new aggregates, giving rise to a positive feedback mechanism responsib
Externí odkaz:
https://doaj.org/article/b790c6f95fb74fe99a38cf76ceda6bf8
Autor:
Francesco Simone Ruggeri, Johnny Habchi, Sean Chia, Robert I. Horne, Michele Vendruscolo, Tuomas P. J. Knowles
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Our understanding of the molecular mechanisms underlying pathological protein aggregation remains incomplete. Here, single molecule infrared nanospectroscopy (AFM-IR) offers insight into the structure of Aβ42 oligomeric and fibrillar species and the
Externí odkaz:
https://doaj.org/article/7f8ac1eb0b6149b48b24e7005907776f
Autor:
Roxine Staats, Thomas C. T. Michaels, Patrick Flagmeier, Sean Chia, Robert I. Horne, Johnny Habchi, Sara Linse, Tuomas P. J. Knowles, Christopher M. Dobson, Michele Vendruscolo
Publikováno v:
Communications Chemistry, Vol 3, Iss 1, Pp 1-9 (2020)
Promising treatments for neurogenerative disorders may involve targeting kinetic intermediates, including α-synuclein oligomers. Here a kinetic method for quantifying oligomer populations is used to screen small molecule inhibitors of oligomerisatio
Externí odkaz:
https://doaj.org/article/25cc20ef6fa54796a866e8e34065ca87
Autor:
Robert I. Horne, Mhd Hussein Murtada, Donghui Huo, Z. Faidon Brotzakis, Rebecca C. Gregory, Andrea Possenti, Sean Chia, Michele Vendruscolo
Publikováno v:
Journal of Chemical Theory and Computation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c7ad2a92ef4436437266ebcfc42f0c5
https://doi.org/10.1021/acs.jctc.2c01303
https://doi.org/10.1021/acs.jctc.2c01303
Autor:
Sean Chia, Z. Faidon Brotzakis, Robert I. Horne, Andrea Possenti, Benedetta Mannini, Rodrigo Cataldi, Magdalena Nowinska, Roxine Staats, Sara Linse, Tuomas P. J. Knowles, Johnny Habchi, Michele Vendruscolo
The presence of amyloid fibrils of α-synuclein is closely associated with Parkinson's disease and related synucleinopathies. It is still very challenging, however, to systematically discover small molecules that prevent the formation of these aberra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dbd8e1463d5fe67caafd768422b1f10
Autor:
Sean Chia, Z. Faidon Brotzakis, Robert I. Horne, Andrea Possenti, Benedetta Mannini, Rodrigo Cataldi, Magdalena Nowinska, Roxine Staats, Sara Linse, Tuomas P. J. Knowles, Johnny Habchi, Michele Vendruscolo
The presence of amyloid fibrils of α-synuclein is closely associated with Parkinson’s disease and related synucleinopathies. It is still very challenging, however, to systematically discover small molecules that prevent the formation of these aber
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1901b63d50de592df73d68c39000fa2c
https://doi.org/10.1101/2021.12.05.471256
https://doi.org/10.1101/2021.12.05.471256
Autor:
Faidon Brotzakis, Andrea Possenti, Michele Vendruscolo, Roxine Staats, Sean Chia, Johnny Habchi, Robert I. Horne
Drug development is an increasingly active area of machine learning application, due to the high attrition rates of conventional drug discovery pipelines. This issue is especially pressing for neurodegenerative diseases where very few disease modifyi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bef78b836df2b33dab5bcdb6037f0e4
https://doi.org/10.1101/2021.11.10.468009
https://doi.org/10.1101/2021.11.10.468009
Autor:
Tuomas P. J. Knowles, Michele Vendruscolo, Johnny Habchi, Robert I. Horne, Sean Chia, Francesco Simone Ruggeri
Publikováno v:
Nature Communications, 12(1)
Nature Communications
Nature Communications 12 (2021) 1
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Nature Communications
Nature Communications 12 (2021) 1
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Significant efforts have been devoted in the last twenty years to developing compounds that can interfere with the aggregation pathways of proteins related to misfolding disorders, including Alzheimer’s and Parkinson’s diseases. However, no disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c3a177d8784656f10bdffe59197f316
https://www.repository.cam.ac.uk/handle/1810/316861
https://www.repository.cam.ac.uk/handle/1810/316861
Autor:
Michele Vendruscolo, Sean Chia, Thomas C. T. Michaels, Sara Linse, Roxine Staats, Tuomas P. J. Knowles, Johnny Habchi, Christopher M. Dobson, Patrick Flagmeier, Robert I. Horne
Publikováno v:
Communications Chemistry, Vol 3, Iss 1, Pp 1-9 (2020)
The aggregation of α-synuclein is a central event in Parkinsons’s disease and related synucleinopathies. Since pharmacologically targeting this process, however, has not yet resulted in approved disease-modifying treatments, there is an unmet need
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d40ec416fec1981e7ccad4421aa80de4
https://www.repository.cam.ac.uk/handle/1810/311894
https://www.repository.cam.ac.uk/handle/1810/311894