Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Robert I. Grove"'
Autor:
Zhihe Li, Robert I. Grove
Publikováno v:
The Asia Pacific Heart Journal. 7:114-120
Gene therapy involves the transfer of therapeutic genes to cells in vivo and is therefore a potentially novel way to treat cardiovascular diseases. Especially good candidate diseases are those arising from inherited mutations in the genetic sequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1409008a1ba2b335b1745eba2271263e
https://doi.org/10.1016/s1328-0163(98)90008-2
https://doi.org/10.1016/s1328-0163(98)90008-2
Autor:
Robert I Grove, Margaret M Snowden
Publikováno v:
Expert Opinion on Therapeutic Patents. 8:509-520
The advent of gene therapy techniques has made it possible to intervene in cardiovascular diseases by transferring an appropriate therapeutic gene to the relevant cells in humans. A number of preclinical efforts have begun to culminate in clinical st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0817a058d72b7f7580b40054607f9679
https://doi.org/10.1517/13543776.8.5.509
https://doi.org/10.1517/13543776.8.5.509
Autor:
George Y. Wu, Robert I Grove
Publikováno v:
Advanced Drug Delivery Reviews. 30:199-204
The development of gene therapy as a potential technique for treating serious metabolic or infectious disorders has generated much interest. The general applicability of gene therapy depends on the efficient transfer of the desired gene to specific t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27d5e5df9646773e85055e8438355ccb
https://doi.org/10.1016/s0169-409x(97)00116-6
https://doi.org/10.1016/s0169-409x(97)00116-6
Autor:
Glenn Warr, Steven M. Seiler, K. S. Hartl, Sadia Abid, Charles E. Mazzucco, Robert I. Grove, M. C. Kowala
Publikováno v:
Arteriosclerosis and Thrombosis: A Journal of Vascular Biology. 13:435-444
We determined the effects of two prostacyclin agonists (octimibate and BMY 42393) on the progression of the fatty streak in vivo and on macrophage function in vitro. Hamsters were fed chow plus 0.05% cholesterol and 10% coconut oil. Control hamsters
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd4b6229c314d085d0baf7bc5f7d969
https://doi.org/10.1161/01.atv.13.3.435
https://doi.org/10.1161/01.atv.13.3.435
Autor:
G Spitalny, Robert I. Grove, Charles E. Mazzucco, Mohammed Shoyab, M Antonaccio, Glenn Warr, Peter A. Kiener, Susan F. Radka, Nick J. Allegretto
Publikováno v:
Journal of Lipid Research, Vol 32, Iss 12, Pp 1889-1897 (1991)
Recent evidence suggests the possibility that macrophages can influence lipoprotein metabolism. Therefore we investigated the ability of cultured macrophages to alter low density lipoprotein (LDL) uptake in a human liver cell line (HepG2). Conditione
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::075af0854b8d530aa7da8004cefeab2d
https://doi.org/10.1016/s0022-2275(20)41892-9
https://doi.org/10.1016/s0022-2275(20)41892-9
Publikováno v:
Journal of Leukocyte Biology. 48:38-42
We investigated the effects of LPS on mouse peritoneal macrophage phospholipids using radiolabeled precursors. LPS (200 ng/ml) stimulated incorporation of [32P] into all classes of phospholipids within 0.5 hr, and after 2 hr the increase was 60% grea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdcf15d8adea8d2068a089e49833a2a9
https://doi.org/10.1002/jlb.48.1.38
https://doi.org/10.1002/jlb.48.1.38
Autor:
Jennifer M. Barton, Julie M. Burgher, Michael M. Farooq, Julie A. Freischlag, Robert W. Scott, Jeff Vasek, Robert I. Grove
Publikováno v:
Cardiovascular radiation medicine. 3(3-4)
Purpose: To demonstrate the feasibility of PhotoPoint photodynamic therapy (PDT) with local drug delivery, optimize dosimetry in a rabbit jugular vein model, and investigate its ability to deplete potential neointimal precursor cells in the vessel wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b44eb2f0a5b1dacd185c48b29433689c
https://pubmed.ncbi.nlm.nih.gov/12974367
https://pubmed.ncbi.nlm.nih.gov/12974367
Autor:
Julie A. Freischlag, Michael M. Farooq, Heidi Nielsen, Steve Rychnovsky, Jennifer M. Barton, Robert I. Grove
Publikováno v:
Cardiovascular radiation medicine. 3(3-4)
Purpose: To evaluate the ability of PhotoPoint photodynamic therapy (PDT) to suppress venous anastomotic intimal hyperplasia (IH) in a canine prosthetic arteriovenous graft (AVG) model. Methods and materials: Bilateral femoral AVGs were placed in 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbcb41a1c950c2e2a02fc95d93fa983f
https://pubmed.ncbi.nlm.nih.gov/12974365
https://pubmed.ncbi.nlm.nih.gov/12974365
Autor:
Robert I. Grove, Lioubov Poliakova, Luis Henrique W. Gowdak, Mark I. Talan, Edward G. Lakatta, Zhihe Li
Publikováno v:
Journal of vascular surgery. 32(2)
Purpose: The purpose of this study was to test the efficacy of a new cationic lipid formulation coupled with the cDNA encoding for the 165-residue form of vascular endothelial growth factor (VEGF165) to induce neovascularization and enhance blood flo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3cb06ce681ae647610116fc1bd727c4
https://pubmed.ncbi.nlm.nih.gov/10917995
https://pubmed.ncbi.nlm.nih.gov/10917995
Autor:
Bruce M. Rankin, Glenn Warr, Sue A. Yocum, Peter A. Kiener, Robert I. Grove, Patricia M. Davis
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 15(7)
Abstract The ability of immune complexes of LDL or acetylated LDL (acLDL), together with antibodies to LDL, to induce a proatherogenic phenotype in human monocytic cells has been explored. Treatment of THP-1 monocytic cells or peripheral human monocy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3fb365dbf638918b5c1329b11257021
https://pubmed.ncbi.nlm.nih.gov/7600130
https://pubmed.ncbi.nlm.nih.gov/7600130