Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Robert I Scheinman"'
Autor:
Casey Patrick, Utibeabasi Ettah, Vu Nguyen, Caitlin Hart, Evan Atchley, Krishna Mallela, Robert I. Scheinman, Andrew A. Monte
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 8, Pp n/a-n/a (2024)
Abstract The OPRM1 gene codes for the mu opioid receptor (MOR) and polymorphisms are associated with complex patient clinical responses. The most studied single nucleotide polymorphism (SNP) in OPRM1 is adenine (A) substituted by guanine (G) at posit
Externí odkaz:
https://doaj.org/article/b4ada26df08e47b7a6ae879b406db0c2
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24616 (2011)
P23H rhodopsin, a mutant rhodopsin, is known to aggregate and cause retinal degeneration. However, its effects on retinal pigment epithelial (RPE) cells are unknown. The purpose of this study was to determine the effect of P23H rhodopsin in RPE cells
Externí odkaz:
https://doaj.org/article/d5e0b4b122b948d7830e0ad9a55d24c3
Autor:
Nirmal K. Banda, Stephen Tomlinson, Robert I. Scheinman, Nhu Ho, Joseline Ramos Ramirez, Gaurav Mehta, Guankui Wang, Vivian Pham Vu, Dmitri Simberg, Liudmila Kulik, V. Michael Holers
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Natural IgM antibodies (NAbs) have been shown to recognize injury-associated neoepitopes and to initiate pathogenic complement activation. The NAb termed C2 binds to a subset of phospholipids displayed on injured cells, and its role(s) in arthritis,
Externí odkaz:
https://doaj.org/article/3f0561d146ae40239d1e120e02c4ec2c
Autor:
V. Michael Holers, Anna Borodovsky, Robert I. Scheinman, Nhu Ho, Joseline Ramos Ramirez, József Dobó, Péter Gál, Jared Lindenberger, Annette G. Hansen, Dhruv Desai, Rasmus Pihl, Steffen Thiel, Nirmal K. Banda
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The complement system plays an important role in the pathogenesis of rheumatoid arthritis (RA). Besides driving lectin pathway (LP) activation, the mannan-binding lectin (MBL)-associated serine proteases (MASPs) also play a key role in regulating the
Externí odkaz:
https://doaj.org/article/cd94dcf173544746aa0910ec80742889
Autor:
Robert I. Scheinman, Nirmal K. Banda
Publikováno v:
Arthritis & Rheumatology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b06a0886b9fbfc42337459efaf56c6ff
https://doi.org/10.1002/art.42555
https://doi.org/10.1002/art.42555
Autor:
Hanmant Gaikwad, Yue Li, Guankui Wang, Ronghui Li, Shaodong Dai, Cody Rester, Ross Kedl, Laura Saba, Nirmal K. Banda, Robert I. Scheinman, Casey Patrick, Krishna M.G. Mallela, S. Moein Moghimi, Dmitri Simberg
Publikováno v:
ACS Nano. 16:8704-8715
Many aspects of innate immune responses to SARS viruses remain unclear. Of particular interest is the role of emerging neutralizing antibodies against the receptor-binding domain (RBD) of SARS-CoV-2 in complement activation and opsonization. To overc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::075a84763c8326e5b06d80f760396cc6
https://doi.org/10.1021/acsnano.2c02794
https://doi.org/10.1021/acsnano.2c02794
Autor:
Robert I. Scheinman, S. Moein Moghimi, Yue Li, Laura Saba, Dmitri Simberg, Ernest Groman, Nirmal K. Banda, Guankui Wang, Lynn Griffin
Publikováno v:
J Control Release
The complement system plays a key role in opsonization and immune clearance of engineered nanoparticles. Understanding the efficiency, inter-subject, and inter-strain differences of complement opsonization in preclinical species can help with transla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20b8db59ce44df334a4affb2a6c162e2
https://doi.org/10.1016/j.jconrel.2021.08.048
https://doi.org/10.1016/j.jconrel.2021.08.048
Autor:
Dmitri Simberg, Hanmant Gaikwad, Ernest Groman, Nirmal K. Banda, Geoffrey Gifford, Guankui Wang, Robert I. Scheinman, Laura Saba, Yue Li
Publikováno v:
Bioconjug Chem
Complement is one of the critical branches of innate immunity that determines the recognition of engineered nanoparticles by immune cells. Antibody-targeted iron oxide nanoparticles are a popular platform for magnetic separations, in vitro diagnostic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7b354050ad0acf77c3d4bc938267783
https://doi.org/10.1021/acs.bioconjchem.0c00342
https://doi.org/10.1021/acs.bioconjchem.0c00342
Autor:
Robert I. Scheinman, Dmitri Simberg, Weston J. Smith, Laren A. Lofchy, Vivian P. Vu, Hanmant Gaikwad, Geoffrey Gifford, Nirmal K. Banda, Joseline Ramos Ramirez
Publikováno v:
Mol Pharm
Diseases of the joints affect over 10% of the world’s population, resulting in significant morbidity. There is an unmet need in strategies for specific delivery of therapeutics to the joints. Collagen type II is synthesized by chondrocytes and is m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc99eb2bde5d2d240836ba2a1ec85217
https://doi.org/10.1021/acs.molpharmaceut.9b00059
https://doi.org/10.1021/acs.molpharmaceut.9b00059
Autor:
Robert I. Scheinman, Joseline Ramos Ramirez, Stephen Tomlinson, V. Michael Holers, Nhu Ho, Gaurav Mehta, Liudmila Kulik, Guankui Wang, Nirmal K. Banda, Dmitri Simberg, Vivian P. Vu
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology, Vol 11 (2020)
Natural IgM antibodies (NAbs) have been shown to recognize injury-associated neoepitopes and to initiate pathogenic complement activation. The NAb termed C2 binds to a subset of phospholipids displayed on injured cells, and its role(s) in arthritis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6011a2e7d12b66e683cdb6eca9fbb20f
https://pubmed.ncbi.nlm.nih.gov/33178202
https://pubmed.ncbi.nlm.nih.gov/33178202