Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Robert Houle"'
Autor:
Kelly Bleasby, Robert Houle, Michael Hafey, Meihong Lin, Jingjing Guo, Bing Lu, Rosa I. Sanchez, Kerry L. Fillgrove
Publikováno v:
Viruses, Vol 13, Iss 8, p 1566 (2021)
Islatravir (MK-8591) is a nucleoside reverse transcriptase translocation inhibitor in development for the treatment and prevention of HIV-1. The potential for islatravir to interact with commonly co-prescribed medications was studied in vitro. Elimin
Externí odkaz:
https://doaj.org/article/d17ac357847f48b79084529598f00883
Autor:
Jocelyn, Yabut, Robert, Houle, Shubing, Wang, Andy, Liaw, Ravi, Katwaru, Hannah, Collier, Lucinda, Hittle, Xiaoyan, Chu
Publikováno v:
Drug Metabolism and Disposition. 50:909-922
The multidrug resistance protein 1 (MDR1) P-glycoprotein (P-gp) is a clinically important transporter. In vitro P-gp inhibition assays have been routinely conducted to predict the potential for clinical drug-drug interactions (DDIs) mediated by P-gp.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86cdd86bf76c6e11bda2332bd055c3be
https://doi.org/10.1124/dmd.121.000807
https://doi.org/10.1124/dmd.121.000807
Autor:
Bhavana Bhatt, Frank D. Sistare, Kiran Palyada, Feifei Chen, Isabelle Bourgeois, Christopher Brynczka, Rupesh P. Amin, Katerina Vlasakova, José A. Lebrón, Roger Smith, Kenneth A. Koeplinger, Kenneth D Anderson, Kathleen Cox, Robert Houle, Warren E. Glaab, Yi-Zhong Gu, Xiaoyan Chu
Publikováno v:
Toxicological Sciences. 172:155-166
MK-7680, a cyclic nucleotide prodrug, caused significant kidney tubule injury in female rats when administered orally at 1000 mg/kg/day for 2 weeks using 10% Polysorbate 80 as vehicle. However, kidney injury was absent when MK-7680 was administered a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a7c8a93f2d09b4d982560ba5c94462b
https://doi.org/10.1093/toxsci/kfz186
https://doi.org/10.1093/toxsci/kfz186
Autor:
Shu-Wen Teng, Michael Hafey, Jeanine Ballard, Xinjie Lin, Changhong Yun, Vijay More, Robert Houle, Ravi Katwaru, Ann Thomas, Grace Chan, Kim Michel, Yutai Li, Kara Pearson, Christopher Gibson
Publikováno v:
Computational Toxicology. 22:100224
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fef461581c647e4a98daa11bb759213
https://doi.org/10.1016/j.comtox.2022.100224
https://doi.org/10.1016/j.comtox.2022.100224
Autor:
James J. Monroe, Ian Knemeyer, Robert Houle, Andreas Baudy, Frank D. Sistare, Michael J. Hafey, Raymond Evers, Jackie Shang, Qing Chen, Keith Q. Tanis
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 48(11)
Hepatocellular accumulation of bile salts by inhibition of bile salt export pump (BSEP/ABCB11) may result in cholestasis and is one proposed mechanism of drug-induced liver injury (DILI). To understand the relationship between BSEP inhibition and DIL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21253d6763d1c3e2f5fa4f7a61d5a63a
https://pubmed.ncbi.nlm.nih.gov/32943412
https://pubmed.ncbi.nlm.nih.gov/32943412
Autor:
Kerry L. Fillgrove, Grace Chan, Rosa I. Sanchez, Meihong Lin, Bing Lu, Deborah J. Newton, Robert Houle, Jairam Palamanda, Kelly Bleasby
Doravirine is a novel nonnucleoside reverse transcriptase inhibitor for the treatment of human immunodeficiency virus type 1 infection. In vitro studies were conducted to assess the potential for drug interactions with doravirine via major drug-metab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f76b0224ecf19334aa1e470533a76d3
https://europepmc.org/articles/PMC6437506/
https://europepmc.org/articles/PMC6437506/
Autor:
Robert Houle
Publikováno v:
Asian Diasporic Visual Cultures and the Americas. 2:255-263
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b74d692a95ded8aa107ddc473ff6d47b
https://doi.org/10.1163/23523085-00203005
https://doi.org/10.1163/23523085-00203005
Publikováno v:
The Journal of antimicrobial chemotherapy. 74(7)
Objectives To identify the transporters involved in renal elimination of relebactam, and to assess the potential of relebactam as a perpetrator or victim of drug-drug interactions (DDIs) for major drug transporters. Methods A series of bidirectional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3790405d04a50e1a0eaa14e93acbe04e
https://pubmed.ncbi.nlm.nih.gov/30891606
https://pubmed.ncbi.nlm.nih.gov/30891606
Autor:
S. Aubrey Stoch, Luzelena Caro, Iain P. Fraser, Xiaoyan Chu, Cynthia Dempsey, Scott Rasmussen, Xiaoxin Cai, Robert Houle, Grace Chan, Prajakti A. Kothare, Stephanie O. Klopfer, Robert Valesky, Raymond Evers, Thomayant Prueksaritanont
Publikováno v:
British Journal of Clinical Pharmacology. 78:587-598
Aims Rosuvastatin and pitavastatin have been proposed as probe substrates for the organic anion-transporting polypeptide (OATP) 1B, but clinical data on their relative sensitivity and selectivity to OATP1B inhibitors are lacking. A clinical study was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abbeedd27a8c3fc075ba548affce4664
https://doi.org/10.1111/bcp.12377
https://doi.org/10.1111/bcp.12377
Publikováno v:
Drug Metabolism and Pharmacokinetics. 33:S64-S65
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c979d60b8ee66f14af5819f68cd194da
https://doi.org/10.1016/j.dmpk.2017.11.216
https://doi.org/10.1016/j.dmpk.2017.11.216