Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Robert Hardt"'
Autor:
Patrick Horten, Kuo Song, Joshua Garlich, Robert Hardt, Lilia Colina-Tenorio, Susanne E. Horvath, Uwe Schulte, Bernd Fakler, Martin van der Laan, Thomas Becker, Rosemary A. Stuart, Nikolaus Pfanner, Heike Rampelt
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113772- (2024)
Summary: The mitochondrial inner membrane plays central roles in bioenergetics and metabolism and contains several established membrane protein complexes. Here, we report the identification of a mega-complex of the inner membrane, termed mitochondria
Externí odkaz:
https://doaj.org/article/39ba88ce92a94d0bbd619eed5dc94114
Autor:
Emre Balta, Robert Hardt, Jie Liang, Henning Kirchgessner, Christian Orlik, Beate Jahraus, Stefan Hillmer, Stefan Meuer, Katrin Hübner, Guido H. Wabnitz, Yvonne Samstag
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
The actin-remodelling protein L-plastin promotes tumour migration and invasion. Here, the authors show that L-plastin is regulated spatially by ROS-induced thiol oxidation which inhibits its actin-bundling function and cell spreading and filopodial e
Externí odkaz:
https://doaj.org/article/8b621a4da982404ea9eb051bd47834de
Autor:
Elisa Balboa, Tamara Marín, Juan Esteban Oyarzún, Pablo S. Contreras, Robert Hardt, Thea van den Bosch, Alejandra R. Alvarez, Boris Rebolledo-Jaramillo, Andres D. Klein, Dominic Winter, Silvana Zanlungo
Publikováno v:
Cells, Vol 10, Iss 8, p 2159 (2021)
Niemann-Pick type C disease (NPCD) is a lysosomal storage disorder caused by mutations in the NPC1 gene. The most affected tissues are the central nervous system and liver, and while significant efforts have been made to understand its neurological c
Externí odkaz:
https://doaj.org/article/bad4e229bef34b36b08551674950517c
Autor:
Robert Hardt, Alireza Dehghani, Carmen Schoor, Markus Gödderz, Nur Cengiz Winter, Shiva Ahmadi, Ramesh Sharma, Karin Schork, Martin Eisenacher, Volkmar Gieselmann, Dominic Winter
SummaryOligodendrocytes are generated via a two-step mechanism from pluripotent neural stem cells (NSCs): after differentiation of NSCs to oligodendrocyte precursor/NG2 cells (OPCs), they further develop into mature oligodendrocytes. The first step o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0db8c4b6e0ac76dfac268eb819a19a35
https://doi.org/10.1101/2023.04.17.537129
https://doi.org/10.1101/2023.04.17.537129
Autor:
Silvia Jordans, Robert Hardt, Ivonne Becker, Dominic Winter, Lihua Wang-Eckhardt, Matthias Eckhardt
Publikováno v:
Molecular Neurobiology. 59:3969-3979
PNS and CNS myelin contain large amounts of galactocerebroside and sulfatide with 2-hydroxylated fatty acids. The underlying hydroxylation reaction is catalyzed by fatty acid 2-hydroxylase (FA2H). Deficiency in this enzyme causes a complicated heredi
Autor:
Kerstin Griess, Michael Rieck, Nadine Müller, Gergely Karsai, Sonja Hartwig, Angela Pelligra, Robert Hardt, Caroline Schlegel, Jennifer Kuboth, Celina Uhlemeyer, Sandra Trenkamp, Kay Jeruschke, Jürgen Weiss, Leon Peifer-Weiss, Weiwei Xu, Sandra Cames, Xiaoyan Yi, Miriam Cnop, Mathias Beller, Holger Stark, Arun Kumar Kondadi, Andreas S. Reichert, Daniel Markgraf, Marianne Wammers, Dieter Häussinger, Oliver Kuss, Stefan Lehr, Decio Eizirik, Heiko Lickert, Eckhard Lammert, Michael Roden, Dominic Winter, Hadi Al-Hasani, Doris Höglinger, Thorsten Hornemann, Jens C. Brüning, Bengt-Frederik Belgardt
Publikováno v:
Nat. Cell Biol. 25, 20–29 (2023)
Impaired proinsulin-to-insulin processing in pancreatic β-cells is a key defective step in both type 1 diabetes and type 2 diabetes (T2D) (refs. 1,2), but the mechanisms involved remain to be defined. Altered metabolism of sphingolipids (SLs) has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2260e154d029f1a9d54ef2017f9e380c
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=67090
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=67090
Autor:
Silvia Jordans, Matthias Eckhardt, Dominic Winter, Robert Hardt, Lihua Wang-Eckhardt, Volkmar Gieselmann
Publikováno v:
Human Molecular Genetics. 29:3616-3630
Spastic paraplegia 35 (SPG35) (OMIM: 612319) or fatty acid hydroxylase-associated neurodegeneration (FAHN) is caused by deficiency of fatty acid 2-hydroxylase (FA2H). This enzyme synthesizes sphingolipids containing 2-hydroxylated fatty acids, which
Autor:
Parth Pandit, Robert Hardt
Modernize your apps, run them in containers on Kubernetes, and understand the business value and the nitty-gritty of the VMware Tanzu portfolio with hands-on instructionsPurchase of the print or kindle book includes a free eBook in the PDF formatKey
Publikováno v:
Biochemical Journal. 475:853-871
The fatty acid 2-hydroxylase (FA2H) is essential for synthesis of 2-hydroxylated fatty acids in myelinating and other cells, and deficiency of this enzyme causes a complicated form of hereditary spastic paraplegia also known as fatty acid hydroxylase
Publikováno v:
PROTEOMICS. 21:2100129
The mass spectrometry-compatible surfactant RapiGest promotes the enzymatic digestion of proteins by facilitating their unfolding while retaining enzymatic activity. RapiGest consists of a hydrophilic head and a hydrophobic tail, which can be separat