Výsledky vyhledávání - "Robert Haigis"

Development and Analytical Validation of a DNA Dual-Strand Approach for the US Food and Drug Administration–Approved Next-Generation Sequencing–Based Praxis Extended RAS Panel for Metastatic Colorectal Cancer Samples

Autor: Amy Mueller, Karen Gutekunst, Tamsen Dunn, Leonard Buchner, Anita Iyer, Margaret Porter, Kristen Meier, Nitin Udar, Paul Wenz, Diane Ward, Jing Lu, Aaron Wise, Shannon E. Smith, Robert Haigis, Shivani Dhillon

Publikováno v: The Journal of Molecular Diagnostics. 22:159-178

A next-generation sequencing method was developed that can distinguish single-stranded modifications from low-frequency somatic mutations present on both strands of DNA in formalin-fixed paraffin-embedded colorectal cancer samples. We applied this me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b86adf344d4ac70b97169b4389bc64
https://doi.org/10.1016/j.jmoldx.2019.09.009

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Abstract 1993: A comprehensive benchmarking of paired whole exome and transcriptome biomarker analysis of response to cancer immunotherapy

Autor: Shile Zhang, Kristina M. Kruglyak, Mahdi Golkaram, Robert Haigis, Raakhee Vijayaraghavan, Sven Bilke, Traci Pawlowski, Shannon Kaplan, Joyee Yao, Li Liu, Michael L. Salmans

Publikováno v: Cancer Research. 80:1993-1993

Recent advances in cancer immunotherapy have revolutionized cancer treatment. Notably, pembrolizumab - an anti-PD1 checkpoint inhibitor - has been approved as first-line treatment for metastatic non-small cell lung cancer. Clinical response to checkp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::109310a2e5daf3bc98d5f8217e0f4388
https://doi.org/10.1158/1538-7445.am2020-1993

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Clinical and analytical accuracy of a 523 gene panel next-generation sequencing (NGS) assay on formalin-fixed paraffin-embedded (FFPE) solid tumour samples

Autor: Traci Pawlowski, Charlene Echegaray, K. O’Brien, Brian Crain, D. Lee, Robert Haigis, J. Dockter, Jennifer Silhavy, Tingting Du, Raakhee Vijayaraghavan, R. Garcia, N. Haseley, I. Deras, A. Mentzer, J. Lee, A. Yazdanparast, Tingting Jiang, Chen Zhao, A. Purdy

Publikováno v: Annals of Oncology. 30:v575-v576

Background We developed a tumor-only NGS assay (TruSight assay), a 523 gene panel covering 1.94 megabases (Mb), that detects small DNA variants, provides a microsatellite instability (MSI) score, and estimates tumor mutational burden (TMB) from FFPE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e3012834a45f0b67ac582f4e3a0bb02
https://doi.org/10.1093/annonc/mdz257.005

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Abstract 3638: A rapid, multiplexed, and highly accurate next-generation sequencing RAS Panel for FFPE colorectal samples reporting on the absence or presence of low frequency somatic variants

Autor: Margaret Porter, Tamsen Dunn, Shannon E. Smith, Nitin Udar, Desiree Lee, Anita Iyer, Robert Haigis

Publikováno v: Cancer Research. 76:3638-3638

Introduction: Next generation sequencing (NGS) is a highly sensitive method for detecting somatic mutations. Mutations in NRAS and KRAS may affect up to 50% of patients with colorectal cancer (CRC). Recent data suggest the clinical benefit of panitum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e95c25c415de4ca35423202e9b723773
https://doi.org/10.1158/1538-7445.am2016-3638

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Detection of 11 Common Viral and Bacterial Pathogens Causing Community-Acquired Pneumonia or Sepsis in Asymptomatic Patients by Using a Multiplex Reverse Transcription-PCR Assay with Manual (Enzyme Hybridization) or Automated (Electronic Microarray) Detection▿

Autor: Elizabeth L. Mather, Meredith Van Dyke, Huong Tang, Marjan Haghnia, Sagarika Tiwari, Madhushree Ghosh, Lihua Wang, William G. Weisburg, Robert Haigis, Andrea J. Kraft, Jiang Fan, Michael E. Bose, Tingquo Luo, Kelly J. Henrickson, Swati Kumar

Community-acquired pneumonia (CAP) and sepsis are important causes of morbidity and mortality. We describe the development of two molecular assays for the detection of 11 common viral and bacterial agents of CAP and sepsis: influenza virus A, influen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa66226953a408135183e311cc04b58
https://europepmc.org/articles/PMC2546717/

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A novel approach to improve detection of somatic DNA variants in solid tumors by next-generation sequencing from FFPE samples

Autor: Qingxiu Zhang, Erich Jaeger, Robert Haigis, Maryam Zenali, Nitin Udar, Thomas Gros, Mark T. Ross, Agda Karina Lucio-Eterovic

Publikováno v: Journal of Clinical Oncology. 31:e22177-e22177

e22177 Background: Low frequency variant detection by sequencing is a highly desired goal for therapy selection in cancer especially the detection of actionable targets. The lower limit of detection using Sanger sequening is ~20% minor allele frequen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1b668183228e00bb2ee85903a68f35f
https://doi.org/10.1200/jco.2013.31.15_suppl.e22177

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