Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Robert H. Swanborg"'
Publikováno v:
Journal of Leukocyte Biology. 83:1128-1135
We report that bone marrow-derived natural killer (BMNK) cells from DA or F344 rats inhibit PMA/ionomycin-induced T cell proliferation. These NK-regulatory cells are NKR-P1Adim, whereas a minor subpopulation is NKR-P1Abright. Only the NKR-P1Adim BMNK
Publikováno v:
Journal of Neuroimmunology. 185:115-122
To investigate whether TLR agonists can replace mycobacteria in adjuvant to induce EAE in Lewis rats, we immunized rats with MBP peptide (MBP(68-86)) in IFA, supplemented with TLR agonists. Rats immunized with MBP(68-86) plus CpG-ODN or LPS in IFA di
Publikováno v:
The Journal of Immunology. 174:4590-4597
NK cells have been shown to influence immune responses via direct interaction with cells of the adaptive immune system, such as dendritic cells, B cells, and T cells. A role for NK cells in down-regulation of T cell responses has been implicated in s
Infectious agents and multiple sclerosis—are Chlamydia pneumoniae and human herpes virus 6 involved?
Publikováno v:
Journal of Neuroimmunology. 136:1-8
A good deal of evidence suggests an infectious component in the development of multiple sclerosis (MS) and, to date, some 20 bacteria and viruses have been associated with the disease. Recent independent sets of studies have implicated the respirator
Publikováno v:
Microbes and Infection. 4:1327-1333
Multiple sclerosis (MS) is thought by many investigators to have an infectious component, and several microorganisms have been associated with the disease during the last three decades. Recent studies have implicated both human herpesvirus 6 (HHV-6)
Autor:
Robert H. Swanborg
Publikováno v:
Immunological Reviews. 184:129-135
Experimental autoimmune encephalomyelitis (EAE) in the rat is an acute paralytic disease from which most animals spontaneously recover. The disease can be induced in susceptible inbred Lewis and DA rats with myelin basic protein (MBP), or encephalito
Autor:
Stephanie B. Conant, Robert H. Swanborg, Judith A. Whittum-Hudson, Hervé C. Gérard, Lin Lu, Derek C. Lenz, Norbert A. Wolf, Alan P. Hudson
Publikováno v:
The Journal of Immunology. 167:1803-1808
It has been reported recently that the bacterial respiratory pathogen Chlamydia pneumoniae is present in the cerebrospinal fluid of a subset of multiple sclerosis (MS) patients. However, it is not known whether this organism is a causative agent of M
Publikováno v:
The Journal of Immunology. 163:1763-1768
This paper reports that DA rats develop experimental autoimmune encephalomyelitis (EAE) when immunized with encephalitogenic myelin basic protein (MBP) peptide (MBP63–81) in IFA. In contrast, most rodent strains are tolerized by this procedure. Dos
Publikováno v:
The Journal of Immunology. 163:1390-1397
Regulation of the immune response is critical to homeostasis. While innate immunity can influence the development of adaptive immune responses, its role in regulation is less well understood. Recently, NK cells have been implicated in the control of
Publikováno v:
The Journal of Immunology. 162:829-836
We synthesized single amino acid-substituted peptide analogues of guinea pig myelin basic protein (MBP) 73–86 to study the importance of aspartic acid at residue 82 (QKSQRSQDENPV), which previous reports have suggested is a critical TCR contact res