Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Robert H. Spaet"'
There has been an enormous growth of interest in the field of toxicologic pathology and particularly on its impact on nonclinical safety assessment in global drug development and in the environment. Toxicologic pathologists play an important role in
There has been a growing interest in toxicologic pathology, especially as related to its impact on the safety assessment of pharmaceuticals and chemicals, and in drug development. Thus, there is a growing need for an Illustrated Dictionary of Toxicol
Publikováno v:
Toxicologic Pathology ISBN: 9780429504624
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fffe50e67c046dcf911fdaa79b3a0ec7
https://doi.org/10.1201/9780429504624-10
https://doi.org/10.1201/9780429504624-10
Autor:
Sabine Francke, Annette Romeike, Daniel J. Patrick, James F. Reindel, Kenneth A Schafer, Kendall S. Frazier, Lindsay Tomlinson, Robert H. Spaet, James D Fikes
Publikováno v:
Toxicologic Pathology. 43:907-914
In 2014, the Organisation for Economic Co-operation and Development (OECD) issued guidance no. 16, Guidance on the GLP Requirements for Peer Review of Histopathology. The stated purpose of the guidance document is “to provide guidance to pathologis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edfe7d585f47dfb4cc209c75f527cff2
https://doi.org/10.1177/0192623315596382
https://doi.org/10.1177/0192623315596382
Autor:
Nick Flavahan, Linda Longo, Pierre Moulin, Wei Zhou, Valerie Dubost, Pritam S. Sahota, Lori Martin, Robert H. Spaet, Serafino Pantano, Heidi A. Schoenfeld, Bryan Burkey, Dan Lapadula, Virendar K. Kaushik, Phil Bentley, Salah-Dine Chibout, Peter Hoffmann, Michael Hayes, Steve Busch
Publikováno v:
Toxicologic Pathology. 42:684-695
The purpose of this article is to characterize skin lesions in cynomolgus monkeys following vildagliptin (dipeptidyl peptidase-4 inhibitor) treatment. Oral vildagliptin administration caused dose-dependent and reversible blister formation, peeling an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f493e4b7ae077b0d9abea167df25abb
https://doi.org/10.1177/0192623313516828
https://doi.org/10.1177/0192623313516828
Autor:
Paul Vancutsem, Marc DeCristofaro, Salah-Dine Chibout, Armin Wolf, Tao Wang, M. Craig Keselica, Francois Pognan, Marion Wiesmann, Elizabeth Skuba, Maria Papoutsi, Judit Markovits, Robert H. Spaet, James Sutton, Pierre Moulin, William Kluwe, Lew Petryk
Publikováno v:
International Journal of Toxicology. 30:300-312
This article addresses the issue of miscorrelation between hepatic injury biomarkers and histopathological findings in the drug development context. Our studies indicate that the use of toxicogenomics can aid in the drug development decision-making p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1062438dffe42d85f393c4f2612c2ecb
https://doi.org/10.1177/1091581811401920
https://doi.org/10.1177/1091581811401920
Publikováno v:
Toxicologic pathology. 20(2)
Historical data are presented for neoplasms and related proliferative lesions from 1,170 Sprague-Dawley rats that served as controls in 9 carcinogenicity (2 year) studies conducted in the Safety Evaluation Facility of Ciba-Geigy Corporation, Summit,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f1cb1baec79aecf56d56c1c667fc35
https://pubmed.ncbi.nlm.nih.gov/1475582
https://pubmed.ncbi.nlm.nih.gov/1475582
Publikováno v:
Toxicologic Pathology. 8:1-21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0f278a672e47fb92c9ea3689420ea87
https://doi.org/10.1177/019262338000800201
https://doi.org/10.1177/019262338000800201
Publikováno v:
Toxicologic Pathology. 11:3-11
Sprague-Dawley CD rats received daily oral doses (45 mg/kg) of the cationic amphiphilic tricyclic antidepressant imipramine HCI (Tofranil®) for up to two years. Representative specimens of liver, lung, spleen, mesenteric lymph node, retina and dorsa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5d4b9943aa10c067e814b2443976811
https://doi.org/10.1177/019262338301100102
https://doi.org/10.1177/019262338301100102