Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Robert H. Sinnamon"'
Autor:
Alastair J King, Marc R Arnone, Maureen R Bleam, Katherine G Moss, Jingsong Yang, Kelly E Fedorowicz, Kimberly N Smitheman, Joseph A Erhardt, Angela Hughes-Earle, Laurie S Kane-Carson, Robert H Sinnamon, Hongwei Qi, Tara R Rheault, David E Uehling, Sylvie G Laquerre
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e67583 (2013)
Mitogen-Activated Protein Kinase (MAPK) pathway activation has been implicated in many types of human cancer. BRAF mutations that constitutively activate MAPK signalling and bypass the need for upstream stimuli occur with high prevalence in melanoma,
Externí odkaz:
https://doaj.org/article/f2ff4fc2ea6640b3bec689c5d38dc373
Publikováno v:
Acta Crystallogr F Struct Biol Commun
Direct soaking of protein crystals with small-molecule fragments grouped into complementary clusters is a useful technique when assessing the potential of a new crystal system to support structure-guided drug discovery. It provides a robustness check
Autor:
Hong Zhang, Benjamin Schwartz, Michael D. Schaber, Mark A. Seefeld, Jon-Paul Jaworski, Guanglei Cui, Shu-Yun Zhang, Kelly Federowicz, Aidan G. Gilmartin, Faitg Thomas H, Martin Brandt, Jingsong Yang, Mark Richter, Robert B. Kirkpatrick, Dean E. McNulty, Neysa Nevins, Arthur Groy, Elsie Diaz, Rakesh Kumar, Stan F. Martens, Amber D. Jones, Dirk A. Heerding, Peng Xin, Robert H. Sinnamon, Elisabeth A. Minthorn, Michael G. Darcy, Beth Pietrak
Publikováno v:
Nature Chemical Biology. 10:181-187
Although therapeutic interventions of signal-transduction cascades with targeted kinase inhibitors are a well-established strategy, drug-discovery efforts to identify targeted phosphatase inhibitors have proven challenging. Herein we report a series
Autor:
Matthew C. Burns, Kyung O. Johanson, Don T. Fisher, Patrick McDevitt, Vaughan R. Leydon, Patricia A. Elkins, Hongwei Qi, Kurt R. Auger, Paris Ward, Maggie Grimes, Thomas D. Sweitzer, Martin Brandt, Benjamin Schwartz, Yu Xue, Robert H. Sinnamon, Ruth Lehr, Thau F. Ho, Christopher S. Jones, Beth Pietrak, Robert B. Kirkpatrick, Giorgia Vincentini
Publikováno v:
Protein Expression and Purification. 73:167-176
Phosphoinositide 3-kinases have been targeted for therapeutic research because they are key components of a cell signaling cascade controlling proliferation, growth, and survival. Direct activation of the PI3Kalpha pathway contributes to the developm
Autor:
Robert A. Copeland, Zhihong Lai, Tia Lewis, Kang Yan, Peter J. Tummino, Lata T. Gooljarsingh, John J. Kerrigan, Robert H. Sinnamon, Kyung O. Johanson, Christine Fernandes, Marc R. Arnone, Michael Grooms, Hong Zhang, Alastair J. King, Robert B. Kirkpatrick
Publikováno v:
Proceedings of the National Academy of Sciences. 103:7625-7630
Heat shock protein (Hsp)90 is emerging as an important therapeutic target for the treatment of cancer. Two analogues of the Hsp90 inhibitor geldanamycin are currently in clinical trials. Geldanamycin (GA) and its analogues have been reported to bind
Autor:
Glenn S. Van Aller, Peter J. Tummino, BaoChau Le, Gloria Mas, Roland S. Annan, Ryan G. Kruger, Patrick McDevitt, Nicolas Reynoird, Olena Barbash, Michael J. Huddleston, Or Gozani, Julien Sage, Shichong Liu, Benjamin A. Garcia, Robert H. Sinnamon, Anne-Flore Zmoos
Publikováno v:
Epigenetics
Epigenetics, Taylor & Francis, 2014, 7 (4), pp.340-343. ⟨10.4161/epi.19506⟩
Epigenetics, Taylor & Francis, 2014, 7 (4), pp.340-343. ⟨10.4161/epi.19506⟩
Smyd3 is a lysine methyltransferase implicated in chromatin and cancer regulation. Here we show that Smyd3 catalyzes histone H4 methylation at lysine 5 (H4K5me). This novel histone methylation mark is detected in diverse cell types and its formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a29467a44d30ceee528cd26dfdecafa
https://hal.archives-ouvertes.fr/hal-02989821
https://hal.archives-ouvertes.fr/hal-02989821
Autor:
Kelly E. Fedorowicz, Hongwei Qi, Angela Hughes-Earle, Joseph A. Erhardt, Robert H. Sinnamon, Marc R. Arnone, Tara Renae Rheault, Katherine G. Moss, Alastair J. King, Sylvie Laquerre, Jingsong Yang, David E. Uehling, Laurie S. Kane-Carson, Maureen R. Bleam, Kimberly N. Smitheman
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 7, p e67583 (2013)
PLoS ONE, Vol 8, Iss 7, p e67583 (2013)
Mitogen-Activated Protein Kinase (MAPK) pathway activation has been implicated in many types of human cancer. BRAF mutations that constitutively activate MAPK signalling and bypass the need for upstream stimuli occur with high prevalence in melanoma,
Autor:
Jeffrey D. Carson, Lusong Luo, Robert H. Sinnamon, Peter J. Tummino, Ruth Lehr, Glenn S. Van Aller, Christine Fernandes, Robert B. Kirkpatrick
Publikováno v:
Analytical biochemistry. 383(2)
Differential activation of the phosphoinositide 3-kinase (PI3K)/AKT pathway has been linked to cancer. Activation occurs through gene amplification and activating mutations. High-frequency mutations in the gene encoding the p110alpha catalytic subuni
Autor:
Glenn S. Van Aller, Kurt R. Auger, Robert H. Sinnamon, Dashyant Dhanak, Ruth Lehr, Robert A. Copeland, Robert B. Kirkpatrick, Lusong Luo, Jeffrey D. Carson, Richard R. Gontarek, Peter J. Tummino
Publikováno v:
The Biochemical journal. 409(2)
The PIK3CA gene, encoding the p110α catalytic subunit of Class IA PI3Ks (phosphoinositide 3-kinases), is frequently mutated in many human tumours. The three most common tumour-derived alleles of p110α, H1047R, E542K and E545K, were shown to potentl