Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Robert H. Keith"'
Publikováno v:
The Journal of Immunology. 206:106.10-106.10
Immunology, metabolic, and pituitary biomarker research in non-human primates (NHP) is essential for the study of several diseases and biological regulation. To meet this need, we developed three NHP MILLIPLEX® multiplex panels: 12-plex NHP Metaboli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c55ceba45fd1e2ee034ca8957539522
https://doi.org/10.4049/jimmunol.206.supp.106.10
https://doi.org/10.4049/jimmunol.206.supp.106.10
Publikováno v:
The Journal of Immunology. 204:159.20-159.20
Cytokine, chemokine and growth factor research plays a significant role in achieving a deeper understanding of the immune system and disease. We recently developed a MILLIPLEX® Human Cytokine/Chemokine/Growth Factor Panel A multiplex assay for simul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d98782ad3a2883caf3ce36d615bb133
https://doi.org/10.4049/jimmunol.204.supp.159.20
https://doi.org/10.4049/jimmunol.204.supp.159.20
Autor:
Jeffrey L. Hirsch, Robert H. Keith, Loreen Stillwell, Pamela De Ciechi, Jian Zhang, Ravi G. Kurumbail, Richard M. Leimgruber, Shaun R. Selness, Huey S. Shieh, Stephen J. Mnich, Yan Zhang, Barry L. Burnette, Michael Hepperle, Robert P. Compton, Raj Devraj, Gail Jungbluth, Win Naing, Joseph B. Monahan, Joseph Portanova, Gary D. Anderson, Heidi R. Hope
Publikováno v:
Pharmacology. 84:42-60
SD0006 is a diarylpyrazole that was prepared as an inhibitor of p38 kinase-alpha (p38alpha). In vitro, SD0006 was selective for p38alpha kinase over 50 other kinases screened (including p38gamma and p38delta with modest selectivity over p38beta). Cry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::417af8711e84292fd44a13daf8ddc013
https://doi.org/10.1159/000227286
https://doi.org/10.1159/000227286
Publikováno v:
The Journal of Immunology. 198:61.11-61.11
Low levels of inflammation are involved in many clinical and sub-clinical disease states like autoimmune diseases. Measuring picogram levels of cytokines is critical for understanding their pathogenesis. Model organisms, such as mice, offer unique ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9bbacb971f04088a979bf818518ae34
https://doi.org/10.4049/jimmunol.198.supp.61.11
https://doi.org/10.4049/jimmunol.198.supp.61.11
Autor:
Robert H. Keith, Hiroyuki Eda, Marshall L. Michener, Jian Zhang, Joseph B. Monahan, David Beidler
Publikováno v:
Cytokine. 52(3)
The aim of this study is to investigate if macrophage-colony stimulating factor (M-CSF) or interleukin-34 (IL-34) induces cytokines or chemokines using human whole blood (HWB) and if an M-CSF- or IL-34-induced cytokine or chemokine production from HW
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b471dac58f086da44d3617dee8a85fb5
https://pubmed.ncbi.nlm.nih.gov/20829061
https://pubmed.ncbi.nlm.nih.gov/20829061
Autor:
Gabriel Mbalaviele, Rajesh V. Devraj, Elizabeth G. Webb, Jeffrey L. Hirsch, Heidi R. Hope, Matthew J. Saabye, Dean Messing, Jian Zhang, Joseph B. Monahan, Shaun R. Selness, John F. Schindler, Loreen Stillwell, Barry L. Burnette, Gary D. Anderson, Robert P. Compton, Xiong Li, Robert H. Keith
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 331(3)
Signal transduction through the p38 mitogen-activated protein (MAP) kinase pathway is central to the transcriptional and translational control of cytokine and inflammatory mediator production. p38 MAP kinase inhibition hence constitutes a promising t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43bf14977f74059927334568730cf7b0
https://pubmed.ncbi.nlm.nih.gov/19720877
https://pubmed.ncbi.nlm.nih.gov/19720877
Autor:
Arthur J. Wittwer, Micky D. Tortorella, Robert L. Hills, Elizabeth C. Arner, and Anne-Marie Malfait, Charles P. Anglin, Robert H. Keith, Grace E. Munie
Publikováno v:
Biochemistry. 46(21)
ADAMTS-4 (aggrecanase-1) is implicated in the breakdown of articular cartilage and is an attractive target for therapeutic intervention in arthritis. Cleavage of the native substrate, aggrecan, occurs through exosite interactions and peptide sequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35468ecf5d97fa627a1c5c46139a81f8
https://pubmed.ncbi.nlm.nih.gov/17487981
https://pubmed.ncbi.nlm.nih.gov/17487981