Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Robert H. Bergstrand"'
Autor:
Jan Aberg, Harry J.G.M. Crijns, Kong I. Lie, Olle Almgren, Tom J.M. Tobé, Jaap Haaksma, Ans C.P. Wiesfeld, Robert H. Bergstrand
Publikováno v:
American Journal of Cardiology, 70(11), 990-996. EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
The electropharmacologic effects and pharmacokinetics of almokalant, a new class III antiarrhythmic, were investigated in a randomized, placebo-controlled, double-blind study, and efficacy was evaluated. Ten post-myocardial infarction patients with c
Autor:
Wade W Sutton, Robert H Bergstrand, Raymond L. Woosley, H T Wolfenden, Ted Wang, G. R. Avant, Dan M. Roden, Grant R. Wilkinson, Lyle A. Siddoway, Alastair J. J. Wood
Publikováno v:
Clinical Pharmacology and Therapeutics. 40:148-154
The antiarrhythmic agent encainide undergoes extensive first-pass hepatic metabolism after oral dosing. The active metabolites O-desmethylencainide and 3-methoxy-O-desmethylencainide are formed in subjects who are extensive metabolizers (EMs), a phen
Autor:
Raymond L. Woosley, William J. Stone, H T Wolfenden, Ted Wang, Alastair J. J. Wood, Robert H Bergstrand, Dan M. Roden, Grant R. Wilkinson
Publikováno v:
Clinical pharmacology and therapeutics. 40(1)
The antiarrhythmic agent encainide undergoes extensive presystemic biotransformation to form O-desmethylencainide (ODE) and 3-methoxy-ODE (MODE) in subjects who exhibit the extensive metabolizer (EM) phenotype for debrisoquin 4-hydroxylation. These m
Autor:
Gordon J. Conard, Robert H Bergstrand, Lyle A. Siddoway, Ted Wang, Katherine A. Thompson, Don Kvam, Dan M. Roden, Raymond L. Woosley
Publikováno v:
Clinical pharmacology and therapeutics. 43(5)
A two-part pharmacokinetic approach was used to prospectively develop and test intravenous flecainide infusion regimens for the acute therapy for ventricular arrhythmias. Initially, each of nine known responders to oral flecainide was given a rapid f
Autor:
Ted Wang, Katherine A. Thompson, Dan M. Roden, Robert H Bergstrand, Lyle A. Siddoway, Henry J. Duff, Raymond L. Woosley
Publikováno v:
The American journal of cardiology. 57(13)
Sotalol is a nonselective β-receptor antagonist that prolongs action potential duration and refractoriness in vitro at higher concentrations than those associated with heart rate slowing. To determine if this additional action can be expressed in hu