Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Robert H. Barker"'
Autor:
Roberto Rodrigues Ferreira, Elen Mello de Souza, Glaucia Vilar-Pereira, Wim M. S. Degrave, Rayane da Silva Abreu, Marcelo Meuser-Batista, Nilma Valéria Caldeira Ferreira, Steve Ledbeter, Robert H. Barker, Sabine Bailly, Jean-Jacques Feige, Joseli Lannes-Vieira, Tania C. de Araújo-Jorge, Mariana Caldas Waghabi
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Chronic Chagasic cardiomyopathy (CCC), a progressive inflammatory and fibrosing disease, is the most prominent clinical form of Chagas disease, a neglected tropical disease caused by Trypanosoma cruzi infection. During CCC, the parasite remains insid
Externí odkaz:
https://doaj.org/article/e96a0e4a824f40eaa385d90cfb0289da
Autor:
Eva Zaccariotto, María Begoña Cachón-González, Bing Wang, Sungtaek Lim, Bradford Hirth, Hyejung Park, Malika Fezoui, S.Pablo Sardi, Paul Mason, Robert H. Barker, Jr, Timothy M. Cox
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 149, Iss , Pp 112808- (2022)
Krabbe disease is a rare, inherited neurodegenerative disease due to impaired lysosomal β-galactosylceramidase (GALC) activity and formation of neurotoxic β-galactosylsphingosine (‘psychosine’). We investigated substrate reduction therapy with
Externí odkaz:
https://doaj.org/article/77cf7efe886d460196850a21fcc8a250
Autor:
Richard Lieberman, Leslie K. Cortes, Grace Gao, Hyejung Park, Bing Wang, Patrick L. Jones, R. Bridge Hunter, John P. Leonard, Robert H. Barker
Publikováno v:
PLoS ONE, Vol 17, Iss 8 (2022)
Globoid cell leukodystrophy (Krabbe disease) is a fatal neurodegenerative, demyelinating disease caused by dysfunctional activity of galactosylceramidase (GALC), leading to the accumulation of glycosphingolipids including psychosine. While oligodendr
Externí odkaz:
https://doaj.org/article/00ddfe55df1b4645bbda90c529f4c8ba
Autor:
John P. Leonard, Leslie K. Cortes, Robert H. Barker, Grace Gao, Richard Lieberman, Robert Hunter
Globoid cell leukodystrophy (Krabbe disease) is a severe demyelinating, neurodegenerative lysosomal storage disorder caused by deficiency in glycosphingolipid catabolic enzyme galactosylceramidase (GALC). Histologically, Krabbe disease is characteriz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8631bd2e27160b99bf63f730ff7faf77
https://doi.org/10.1101/2021.10.16.464657
https://doi.org/10.1101/2021.10.16.464657
Autor:
Gregory J Crowther, Michael L Booker, Min He, Ting Li, Sylvine Raverdy, Jacopo F Novelli, Panqing He, Natalie R G Dale, Amy M Fife, Robert H Barker, Martin L Kramer, Wesley C Van Voorhis, Clotilde K S Carlow, Ming-Wei Wang
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 1, p e2628 (2014)
Cofactor-independent phosphoglycerate mutase (iPGAM) is essential for the growth of C. elegans but is absent from humans, suggesting its potential as a drug target in parasitic nematodes such as Brugia malayi, a cause of lymphatic filariasis (LF). iP
Externí odkaz:
https://doaj.org/article/98496e16c5644c019eda396ba401a567
Autor:
Mark Munson, James Pribish, Lim Sungtaek, Maniar Sachin, Bradford H. Hirth, Robert H. Barker, Jiang John Z, Yong Mi Choi-Sledeski, Sukanthini Thurairatnam, Kwon Yon Musick, Elina Makino, John E. Macor
Publikováno v:
ACS Med Chem Lett
[Image: see text] Metachromatic leukodystrophy (MLD) is a rare, genetic lysosomal storage disorder caused by the deficiency of arylsulfatase A enzyme, which results in the accumulation of sulfatide in the lysosomes of the tissues of central and perip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee0e9cd71be8f13535f7151488851852
https://europepmc.org/articles/PMC7549271/
https://europepmc.org/articles/PMC7549271/
Autor:
Tiffany Yu, Manoj T. Duraisingh, Kai-Min Lin, Christof Grüring, Elizabeth S. Egan, Michael P. Weekes, Usheer Kanjee, Robert H. Barker, Jale Manzo, Patrick L Jones, Mudit Chaand
Publikováno v:
Proceedings of the National Academy of Sciences. 114
During malaria blood-stage infections, Plasmodium parasites interact with the RBC surface to enable invasion followed by intracellular proliferation. Critical factors involved in invasion have been identified using biochemical and genetic approaches
Autor:
Xavier Fernàndez-Busquets, Patricia Urbán, Robert H. Barker, Anne Grobler, Pieter Buys Burger, Lyn-Marie Birkholtz, Jandeli Niemand, Dina Le Roux, Abraham I. Louw, Adelfa E. Serrano
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance
Graphical abstract
Highlights • A highly specific inhibitor, Genz-644131, was identified for P. falciparum AdoMetDC. • Increased specificity for bifunctional over monofunctional PfAdoMetDC was shown. • Genz-644131 showed improved inhibitio
Highlights • A highly specific inhibitor, Genz-644131, was identified for P. falciparum AdoMetDC. • Increased specificity for bifunctional over monofunctional PfAdoMetDC was shown. • Genz-644131 showed improved inhibitio
Autor:
Adelfa E. Serrano, Jeffrey D. Dvorin, Emily R. Derbyshire, Clary B. Clish, Ralph Mazitschek, Carolyn K. Dong, Jon Clardy, Robert H. Barker, Jose F. Garcia-Bustos, Manoj T. Duraisingh, Vishal Patel, Maria Jose Lafuente, Leila S. Ross, Joseph F. Cortese, Bradley I. Coleman, Sameer Urgaonkar, Mandy Cromwell, Francisco-Javier Gamo, Dyann F. Wirth
Publikováno v:
Chemistry & Biology. 18(12):1602-1610
SummaryHere we report the discovery of tetracyclic benzothiazepines (BTZs) as highly potent and selective antimalarials along with the identification of the Plasmodium falciparum cytochrome bc1 complex as the primary functional target of this novel c
Autor:
Ralph Mazitschek, Mandy Cromwell, Adelfa E. Serrano, Robert H. Barker, Dyann F. Wirth, Joseph F. Cortese, Jon Clardy, Sameer Urgaonkar
Publikováno v:
Org Lett
[Image: see text] The development of a concise strategy to access 2-amino-3-hydroxy-indoles, which are disclosed as novel antimalarials with potent in vivo activity, is reported. Starting from isatins the target compounds are synthesized in 2 steps a