Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Robert H. Arch"'
Autor:
Ralf Glatthar, Robert H. Arch
Publikováno v:
Burger's Medicinal Chemistry and Drug Discovery. :1-71
Autor:
Jeanhee Chung, Susan B. Liu, Detlef Schuppan, Yury Popov, Naoki Ikenaga, Shinji Ogawa, Yong Ook Kim, Shuhei Yoshida, Zhenwei Peng, Robert H. Arch, Makoto Miyamoto, Deanna Y. Sverdlov
Publikováno v:
Gastroenterology. 147:1378-1392
Platelet-derived growth factor-β (PDGFB) is a mitogen for hepatic stellate cells (HSCs). We studied the cellular sources of PDGFB and the effects of a high-affinity monoclonal antibody against PDGFB (MOR8457) in mouse models of biliary fibrosis.Cell
Autor:
Juliet Emamaullee, A. M. James Shapiro, Michael McCall, Joy Davis, Rena Pawlick, Tatsuya Kin, Robert H. Arch, Christian Toso, Allison H. Maciver, Ryan Edgar
Publikováno v:
Surgery
Surgery, Vol. 150, No 1 (2011) pp. 48-55
Surgery, Vol. 150, No 1 (2011) pp. 48-55
Background Islet transplantation has become a viable option for selected type 1 diabetic patients; however, a significant portion need to return to exogenous insulin. The predominant factors include impaired islet engraftment and early islet loss. Ca
Autor:
Mark A. Moffat, Kazuyuki Inagaki, Hideaki Shimada, Bernard N. Violand, Shinji Ogawa, Robert H. Arch, Jaime L. Masferrer, Aisuke Nii, Isami Fujita, Madan Katragadda, Takashi Ochi
Publikováno v:
Hepatology Research. 40:1128-1141
Aim: To evaluate the usefulness of a platelet-derived growth factor (PDGF)-B specific monoclonal antibody (mAb) as a therapeutic agent to treat chronic liver fibrosis. Methods: Liver fibrosis was induced in ICR mice by bile duct ligation (BDL) or BAL
Autor:
Robert H. Arch, Edward M. Esparza
Publikováno v:
The Journal of Immunology. 174:7875-7882
Glucocorticoid-induced TNFR (GITR) has been implicated as an essential regulator of immune responses to self tissues and pathogens. We have recently shown that GITR-induced cellular events promote survival of naive T cells, but are insufficient to pr
Autor:
Jeffrey J. Atkinson, Diane G. Kelley, Jeffrey H. Miner, Tracy L. Adair-Kirk, Robert H. Arch, Robert M. Senior
Publikováno v:
The Journal of Immunology. 174:1621-1629
Tissue injury triggers inflammatory responses that may result in release of degradation products or exposure of cryptic domains of extracellular matrix components. Previously, we have shown that a cryptic peptide (AQARSAASKVKVSMKF) in the α-chain of
Autor:
Robert H. Arch
Publikováno v:
Immunologic Research. 32:015-030
Effector cells play a crucial role in the immune system of higher vertebrates in eliminating invading pathogens and transformed cells that could cause disease or death of the individual. To be effective and specific, immune responses have to distingu
Publikováno v:
Journal of Leukocyte Biology. 75:350-357
Members of the TNF receptor (TNFR) superfamily are cell-surface proteins that can be found on most cell types including lymphocytes. Although some TNFR-related molecules are constitutively expressed, others, such as CD30 and Ox40, are induced upon ac
Publikováno v:
Biochemical and Biophysical Research Communications. 272:936-945
Tumor necrosis factor (TNF) receptor-associated factors (TRAFs) are involved in signaling pathways triggered by members of the TNF receptor (TNFR) family and other cell surface proteins. After recruitment to a receptor, TRAFs initiate formation of mu
Autor:
Robert H. Arch, Craig B. Thompson
Publikováno v:
Molecular and Cellular Biology. 18:558-565
Members of the tumor necrosis factor (TNF)-nerve growth factor (NGF) receptor family have been shown to be important costimulatory molecules for cellular activation. 4-1BB and Ox40 are two recently described members of this protein family which are e