Výsledky vyhledávání - "Robert H Wallis"

Akademický článek

Pathophysiological, genetic and gene expression features of a novel rodent model of the cardio-metabolic syndrome.

Autor: Robert H Wallis, Stephan C Collins, Pamela J Kaisaki, Karène Argoud, Steven P Wilder, Karin J Wallace, Massimiliano Ria, Alain Ktorza, Patrik Rorsman, Marie-Thérèse Bihoreau, Dominique Gauguier

Publikováno v: PLoS ONE, Vol 3, Iss 8, p e2962 (2008)

BACKGROUND:Complex etiology and pathogenesis of pathophysiological components of the cardio-metabolic syndrome have been demonstrated in humans and animal models. METHODOLOGY/PRINCIPAL FINDINGS:We have generated extensive physiological, genetic and g

Externí odkaz: https://doaj.org/article/1872e1fd71ef4dab85caf745480c854a

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Akademický článek

Transcriptome Profiling in Rat Inbred Strains and Experimental Cross Reveals Discrepant Genetic Architecture of Genome-Wide Gene Expression

Autor: Pamela J. Kaisaki, Georg W. Otto, Karène Argoud, Stephan C. Collins, Robert H. Wallis, Steven P. Wilder, Anthony C. Y. Yau, Christophe Hue, Sophie Calderari, Marie-Thérèse Bihoreau, Jean-Baptiste Cazier, Richard Mott, Dominique Gauguier

Publikováno v: G3: Genes, Genomes, Genetics, Vol 6, Iss 11, Pp 3671-3683 (2016)

To test the impact of genetic heterogeneity on cis- and trans-mediated mechanisms of gene expression regulation, we profiled the transcriptome of adipose tissue in 20 inbred congenic strains derived from diabetic Goto–Kakizaki (GK) rats and Brown�

Externí odkaz: https://doaj.org/article/6bcff2133149453ca150abb910cd16f2

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A Functional Polymorphism of Ptpn22 Is Associated with Type 1 Diabetes in the BioBreeding Rat

Autor: Janice Sarmiento, Åke Lernmark, Leili Marandi, Philippe Poussier, Robert H. Wallis, Gary Chao, André Veillette, Terri Ning, Andrew D. Paterson

Publikováno v: The Journal of Immunology. 194:615-629

The R620W variant of PTPN22 is one of the major genetic risk factors for several autoimmune disorders including type 1 diabetes (T1D) in humans. In the BioBreeding T1D-prone (BBDP) rat, a single nucleotide polymorphism in Ptpn22 results in an A629T s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f85fdb6d4e3650b47e3890f7d5a1b55
https://doi.org/10.4049/jimmunol.1302689

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Transcriptome Profiling in Rat Inbred Strains and Experimental Cross Reveals Discrepant Genetic Architecture of Genome-Wide Gene Expression

Autor: Stephan C. Collins, Dominique Gauguier, Marie-Thérèse Bihoreau, Robert H. Wallis, Richard Mott, Sophie Calderari, Jean-Baptiste Cazier, Steven P. Wilder, Anthony C. Y. Yau, Christophe Hue, Karène Argoud, Georg W. Otto, Pamela J. Kaisaki

Publikováno v: G3
G3, 2016, 6 (11), pp.3671-3683. ⟨10.1534/g3.116.033274⟩
G3, Genetics Society of America, 2016, 6 (11), pp.3671-3683. ⟨10.1534/g3.116.033274⟩
G3: Genes, Genomes, Genetics, Vol 6, Iss 11, Pp 3671-3683 (2016)
G3, Genetics Society of America, 2016, 6 (11), pp.3671-3683. 〈10.1534/g3.116.033274〉
G3: Genes|Genomes|Genetics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eeafc5e60b0592260cc6a2a9de71ea6
https://hal.sorbonne-universite.fr/hal-01425993

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Localization of tub and uncoupling proteins (Ucp) 2 and 3 to a region of rat chromosome 1 linked to glucose intolerance and adiposity in the Goto-Kakizaki (GK) type 2 diabetic rat

Autor: Pamela J. Kaisaki, Mark Lathrop, Robert H. Wallis, Peng Y. Woon, Dominique Gauguier, Anthony P. Monaco

Uncoupling proteins (UCP) 2 and UCP3 are closely related to themitochondrial membrane protein UCP1, which can dissociate res-piration from ATP synthesis, resulting in the generation of heat(Fleury et al. 1997; Boss et al. 1997; Vidal-Puig et al. 1997

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a21565449dc8226ef87066f77d25d98c
https://doi.org/10.1007/s003359900895

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Type 1 Diabetes in the BB Rat: A Polygenic Disease

Autor: Philippe Poussier, Leili Marandi, Gary Y.C. Chao, Robert H. Wallis, Terri Ning, Janice Sarmiento, Eugene Hsieh, Kesheng Wang, Andrew D. Paterson

Publikováno v: Diabetes

OBJECTIVE Two type 1 diabetes susceptibility genes have been identified in the spontaneously diabetic biobreeding diabetes-prone (BBDP) rat, the major histocompatibility complex (MHC) (RT1) class II u haplotype (Iddm1) and Gimap5 (Iddm2). The strong

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d40a13f5b64c1e3616db0d80c6fc4a
https://doi.org/10.2337/db08-1215

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Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models

Autor: Ulla G. Sidelmann, Lisa D'Amato, Robert H. Wallis, Christine Blancher, Jane F. Fearnside, Richard H. Barton, Hector C. Keun, Karène Argoud, Marc-Emmanuel Dumas, Dominique Gauguier, Jeremy K. Nicholson, Steven P. Wilder, Dorrit Baunsgaard, James Scott, Marie-Thérèse Bihoreau

Publikováno v: Nature Genetics. 39:666-672

Characterizing the relationships between genomic and phenotypic variation is essential to understanding disease etiology. Information-dense data sets derived from pathophysiological1, proteomic2,3 and transcriptomic4 profiling have been applied to ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84eb80740df057a85e7f26e3fb16c399
https://doi.org/10.1038/ng2026

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Genetic control of plasma lipid levels in a cross derived from normoglycaemic Brown Norway and spontaneously diabetic Goto–Kakizaki rats

Autor: M. T. Bihoreau, Alain Ktorza, Dominique Gauguier, Peng Y. Woon, Steven P. Wilder, Karène Argoud, Robert H. Wallis, F. Ouali, M. A. McAteer

Publikováno v: Diabetologia. 49:2679-2688

AIMS/HYPOTHESIS: Dyslipidaemia is a main component of the insulin resistance syndrome. The inbred Goto-Kakizaki (GK) rat is a model of spontaneous type 2 diabetes and insulin resistance, which has been used to identify diabetes-related susceptibility

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef18a289ed639ada5bcc277a598526db
https://doi.org/10.1007/s00125-006-0396-z

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Mapping diabetes QTL in an intercross derived from a congenic strain of the Brown Norway and Goto-Kakizaki rats

Autor: Marie-Thérèse Bihoreau, Karin J. Wallace, Steven P. Wilder, Karène Argoud, Stephan C. Collins, Robert H. Wallis, Dominique Gauguier, Pamela J. Kaisaki

Publikováno v: Mammalian Genome. 17:538-547

Genetic studies in experimental crosses derived from the inbred Goto-Kakizaki (GK) rat model of spontaneous diabetes mellitus have identified quantitative trait loci (QTL) for diabetes phenotypes in a large region of rat Chromosome (RNO) 1. To test t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d648fa334282c13a20b7046ccd142a61
https://doi.org/10.1007/s00335-005-0168-y

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Marker-assisted congenic screening ( MACS ): A database tool for the efficient production and characterization of congenic lines

Autor: Stephan C. Collins, Dominique Gauguier, Karin J. Wallace, Robert H. Wallis, M. T. Bihoreau

Publikováno v: Mammalian Genome. 14:350-356

Over the past decades, genetic studies in rodent models of human multifactorial disorders have led to the detection of numerous chromosomal regions associated with disease phenotypes. Owing to the complex control of these phenotypes and the size of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daab67f6d4cca4f0a48eb371119e25af
https://doi.org/10.1007/s00335-002-3058-6

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