Zobrazeno 1 - 10
of 435
pro vyhledávání: '"Robert H Singer"'
Autor:
Sandipan Dasgupta, Daniella Y Dayagi, Gal Haimovich, Emanuel Wyler, Tsviya Olender, Robert H Singer, Markus Landthaler, Jeffrey E Gerst
Publikováno v:
eLife, Vol 12 (2023)
Full-length mRNAs transfer between adjacent mammalian cells via direct cell-to-cell connections called tunneling nanotubes (TNTs). However, the extent of mRNA transfer at the transcriptome-wide level (the ‘transferome’) is unknown. Here, we analy
Externí odkaz:
https://doaj.org/article/92dc7283d54146dead5e2628d03760f7
Autor:
Tatsuhisa Tsuboi, Matheus P Viana, Fan Xu, Jingwen Yu, Raghav Chanchani, Ximena G Arceo, Evelina Tutucci, Joonhyuk Choi, Yang S Chen, Robert H Singer, Susanne M Rafelski, Brian M Zid
Publikováno v:
eLife, Vol 9 (2020)
Mitochondria are dynamic organelles that must precisely control their protein composition according to cellular energy demand. Although nuclear-encoded mRNAs can be localized to the mitochondrial surface, the importance of this localization is unclea
Externí odkaz:
https://doaj.org/article/50c39e2aaf1d4fd7a576af5169521570
Publikováno v:
eLife, Vol 8 (2019)
Temporal patterning is a seminal method of expanding neuronal diversity. Here we unravel a mechanism decoding neural stem cell temporal gene expression and transforming it into discrete neuronal fates. This mechanism is characterized by hierarchical
Externí odkaz:
https://doaj.org/article/17607076d83e495f8f00c13bfd767dff
Publikováno v:
eLife, Vol 8 (2019)
The vast majority of the adult fly ventral nerve cord is composed of 34 hemilineages, which are clusters of lineally related neurons. Neurons in these hemilineages use one of the three fast-acting neurotransmitters (acetylcholine, GABA, or glutamate)
Externí odkaz:
https://doaj.org/article/b989515284d049069e6faf58c25f61b8
Autor:
Albert Tsai, Anand K Muthusamy, Mariana RP Alves, Luke D Lavis, Robert H Singer, David L Stern, Justin Crocker
Publikováno v:
eLife, Vol 6 (2017)
Transcription factors bind low-affinity DNA sequences for only short durations. It is not clear how brief, low-affinity interactions can drive efficient transcription. Here, we report that the transcription factor Ultrabithorax (Ubx) utilizes low-aff
Externí odkaz:
https://doaj.org/article/a145c2cd935c4eba81ff6c682d5bea35
Autor:
Zachary B Katz, Brian P English, Timothée Lionnet, Young J Yoon, Nilah Monnier, Ben Ovryn, Mark Bathe, Robert H Singer
Publikováno v:
eLife, Vol 5 (2016)
Messenger RNA localization is important for cell motility by local protein translation. However, while single mRNAs can be imaged and their movements tracked in single cells, it has not yet been possible to determine whether these mRNAs are actively
Externí odkaz:
https://doaj.org/article/46e36cf08f3d447aaa02922fcc3821f4
Autor:
Maria Vera, Bibhusita Pani, Lowri A Griffiths, Christian Muchardt, Catherine M Abbott, Robert H Singer, Evgeny Nudler
Publikováno v:
eLife, Vol 3 (2014)
Translation elongation factor eEF1A has a well-defined role in protein synthesis. In this study, we demonstrate a new role for eEF1A: it participates in the entire process of the heat shock response (HSR) in mammalian cells from transcription through
Externí odkaz:
https://doaj.org/article/1f9f7be653c44fb5ab7db6c16b72293f
Autor:
Maria de Nazareth Leal de Meirelles, Mirian Claudia S Pereira, Robert H Singer, Maria de Nazaré C Soeiro, Luciana R Garzoni, Dayse T Silva, Helene S Barbosa, Tania C Araujo-Jorge, Masako O Masuda, Marcia AM Capella, Anibal Gil Lopes, Alane B Vermelho
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 94, Pp 149-152 (1999)
The present paper summarizes new approaches regarding the progress done to the understanding of the interaction of Trypanosoma cruzi-cardiomyocytes. Mannose receptors localized at the surface of heart muscle cell are involved in binding and uptake of
Externí odkaz:
https://doaj.org/article/7f0b318180414339ab2a46213218e50c
Autor:
Daniel R Larson, Christoph Fritzsch, Liang Sun, Xiuhau Meng, David S Lawrence, Robert H Singer
Publikováno v:
eLife, Vol 2 (2013)
Single-cell analysis has revealed that transcription is dynamic and stochastic, but tools are lacking that can determine the mechanism operating at a single gene. Here we utilize single-molecule observations of RNA in fixed and living cells to develo
Externí odkaz:
https://doaj.org/article/d00fedd288b642ef90927ea5b1ebe1fe
Autor:
Yi-ying Chou, Nicholas S Heaton, Qinshan Gao, Peter Palese, Robert H Singer, Timothée Lionnet
Publikováno v:
PLoS Pathogens, Vol 9, Iss 5, p e1003358 (2013)
The Influenza A virus genome consists of eight negative sense, single-stranded RNA segments. Although it has been established that most virus particles contain a single copy of each of the eight viral RNAs, the packaging selection mechanism remains p
Externí odkaz:
https://doaj.org/article/149978ab166748f8804a936920f5f9cd