Post-transcriptional regulation of Transforming Growth Factor Beta-1 by microRNA-744.

Autor: John Martin, Robert H Jenkins, Rasha Bennagi, Aleksandra Krupa, Aled O Phillips, Timothy Bowen, Donald J Fraser

Publikováno v: PLoS ONE, Vol 6, Iss 10, p e25044 (2011)

Transforming Growth Factor Beta-1 (TGF-β1) is a pleiotropic cytokine that is of central importance in wound healing, inflammation, and in key pathological processes including cancer and progressive tissue fibrosis. TGF-β1 is post-transcriptionally

Externí odkaz: https://doaj.org/article/1cfc9e5850c84e609d330e07ba43a790

Effective In Vivo Gene Modification in Mouse Tissue-Resident Peritoneal Macrophages by Intraperitoneal Delivery of Lentiviral Vectors

Autor: Natacha Ipseiz, Magdalena A. Czubala, Valentina M.T. Bart, Luke C. Davies, Robert H. Jenkins, Paul Brennan, Philip R. Taylor

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 16, Iss , Pp 21-31 (2020)

Tissue-resident macrophages exhibit specialized phenotypes dependent on their in vivo physiological niche. Investigation of their function often relies upon complex whole mouse transgenic studies. While some appropriate lineage-associated promoters e

Externí odkaz: https://doaj.org/article/1360d692efc14b4ebc8d90683a83c58d

miR-141 mediates recovery from acute kidney injury

Autor: Katherine Simpson, Donald James Fraser, Timothy Bowen, Lluís Bailach de Rivera, Robert H. Jenkins, Yueh-An Lu, William John Watkins, Melisa Lopez-Anton, Usman Khalid, Imogen J. John, Lucy J. Newbury

Publikováno v: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)

Acute kidney injury (AKI) is a global clinical problem characterised by a sudden decline in renal function and mortality as high as 60%. Current AKI biomarkers have limited ability to classify disease progression and identify underlying pathological

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ffae601bf8585e8ce21db3c39544327
http://europepmc.org/articles/PMC8363617

Effective In Vivo Gene Modification in Mouse Tissue-Resident Peritoneal Macrophages by Intraperitoneal Delivery of Lentiviral Vectors

Autor: Robert H. Jenkins, Luke C. Davies, Valentina M T Bart, Philip R. Taylor, Natacha Ipseiz, Magdalena A. Czubala, Paul Brennan

Publikováno v: Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss, Pp 375-(2020)
Molecular Therapy: Methods & Clinical Development, Vol 16, Iss, Pp 21-31 (2020)

Tissue-resident macrophages exhibit specialized phenotypes dependent on their in vivo physiological niche. Investigation of their function often relies upon complex whole mouse transgenic studies. While some appropriate lineage-associated promoters e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa1c7df463fc6401b908b4593029b93
http://europepmc.org/articles/PMC6838965

Hyaluronidase-2 regulates RhoA signalling, myofibroblast contractility and other key pro-fibrotic myofibroblast functions

Autor: Rafael Chavez, Vincent C. Hascall, Adam C. Midgley, Robert Steadman, Emma L. Woods, Charlotte V.M. Brown, Robert H. Jenkins, Aled O. Phillips, Usman Khalid, Soma Meran

Publikováno v: The American Journal of Pathology

Hyaluronidase-2 (HYAL2) is a weak, acid-active hyaluronan-degrading enzyme that is broadly expressed in somatic tissues. Aberrant HYAL2 expression is implicated in diverse pathology. However, a significant proportion of HYAL2 is enzymatically inactiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d2c2ebb1031cbf923352018c5e47f5
https://orca.cardiff.ac.uk/id/eprint/130889/8/PIIS0002944020301334.pdf