Výsledky vyhledávání - "Robert H E Friesen"

Akademický článek

Mechanisms of hemagglutinin targeted influenza virus neutralization.

Autor: Boerries Brandenburg, Wouter Koudstaal, Jaap Goudsmit, Vincent Klaren, Chan Tang, Miriam V Bujny, Hans J W M Korse, Ted Kwaks, Jason J Otterstrom, Jarek Juraszek, Antoine M van Oijen, Ronald Vogels, Robert H E Friesen

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e80034 (2013)

Human monoclonal antibodies have been identified which neutralize broad spectra of influenza A or B viruses. Here, we dissect the mechanisms by which such antibodies interfere with infectivity. We distinguish four mechanisms that link the conserved h

Externí odkaz: https://doaj.org/article/94c3128c61834b27bb660217681e881d

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Akademický článek

New class of monoclonal antibodies against severe influenza: prophylactic and therapeutic efficacy in ferrets.

Autor: Robert H E Friesen, Wouter Koudstaal, Martin H Koldijk, Gerrit Jan Weverling, Just P J Brakenhoff, Peter J Lenting, Koert J Stittelaar, Albert D M E Osterhaus, Ronald Kompier, Jaap Goudsmit

Publikováno v: PLoS ONE, Vol 5, Iss 2, p e9106 (2010)

BackgroundThe urgent medical need for innovative approaches to control influenza is emphasized by the widespread resistance of circulating subtype H1N1 viruses to the leading antiviral drug oseltamivir, the pandemic threat posed by the occurrences of

Externí odkaz: https://doaj.org/article/a18d9b465c634aafa91631ed935c70d4

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Potent peptidic fusion inhibitors of influenza virus

Autor: Bart Stoops, Rob J. Vreeken, Chan Tang, Wim Bert Griet Schepens, Rameshwar U. Kadam, Jaap Goudsmit, Bart Rudolf Romanie Kesteleyn, Maria J. P. van Dongen, Wouter Goutier, Jan Vermond, Ronald Vogels, Boerries Brandenburg, Ian A. Wilson, Jarek Juraszek, Christophe Buyck, Robert H. E. Friesen

Publikováno v: Science. 358:496-502

Broadly reactive drugs for flu Drugs for influenza are limited. For those available, viral resistance is rife. Part of the problem is that the virus is constantly mutating. Kadam et al. tested the cell entry stage of the virus life cycle as a drug ta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3194b81b5624b59d020e5f61404c9763
https://doi.org/10.1126/science.aan0516

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Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin

Publikováno v: Science (New York, N.Y.). 362(6414)

Durable influenza protection Vaccines are indispensable for the control and prevention of influenza, but there are several challenges to efficacy. Some individuals respond poorly to vaccination, and virus variation makes targeting optimal antigens di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba4d62a5d4bf4454df09a6c0a7d6843
https://pubmed.ncbi.nlm.nih.gov/30573785

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A common solution to group 2 influenza virus neutralization

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 111(1), 445-450. National Academy of Sciences

The discovery and characterization of broadly neutralizing antibodies (bnAbs) against influenza viruses have raised hopes for the development of monoclonal antibody (mAb)-based immunotherapy and the design of universal influenza vaccines. Only one hu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc70d1c1fdbdebbb7708568ac9a167b0
https://doi.org/10.1073/pnas.1319058110

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Pre- and postexposure use of human monoclonal antibody against H5N1 and H1N1 influenza virus in mice: viable alternative to oseltamivir

Autor: Wouter Koudstaal, Lisette A. H. M. Cornelissen, Just P. J. Brakenhoff, Gerrit Jan Weverling, Martin H. Koldijk, Robert H. E. Friesen, Jaap Goudsmit

Publikováno v: Journal of infectious diseases, 200(12), 1870-1873. Oxford University Press
The Journal of Infectious Diseases, 200(12), 1870-1873
The Journal of Infectious Diseases
The Journal of Infectious Diseases 200 (2009) 12

New strategies to prevent and treat influenza virus infections are urgently needed. A recently discovered class of monoclonal antibodies (mAbs) neutralizing an unprecedented spectrum of influenza virus subtypes may have the potential for future use i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15c179a75e73d84cb8d9614bfc8a314b
https://doi.org/10.1086/648378

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Relating influenza virus membrane fusion kinetics to stoichiometry of neutralizing antibodies at the single-particle level

Autor: Martin H. Koldijk, Samaneh Mashaghi, Jaap Goudsmit, Antoine M. van Oijen, Chan Tang, Ronald Vogels, Boerries Brandenburg, Jarek Juraszek, Ted Kwaks, Jason J. Otterstrom, Robert H. E. Friesen

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 111(48), E5143-E5148. National Academy of Sciences

The ability of antibodies binding the influenza hemagglutinin (HA) protein to neutralize viral infectivity is of key importance in the design of next-generation vaccines and for prophylactic and therapeutic use. The two antibodies CR6261 and CR8020 h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e70cd320127500be4a415b1bb7449700
https://doi.org/10.1073/pnas.1411755111

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Mechanisms of hemagglutinin targeted influenza virus neutralization

Autor: Hans J. W. M. Korse, Jaap Goudsmit, Robert H. E. Friesen, Ted Kwaks, Ronald Vogels, Boerries Brandenburg, Wouter Koudstaal, Miriam V. Bujny, Chan Tang, Jarek Juraszek, Jason J. Otterstrom, Vincent Klaren, Antoine M. van Oijen

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e80034 (2013)
PLoS ONE, 8(12):e80034. PUBLIC LIBRARY SCIENCE
PLoS ONE
PLoS ONE, 8(12). Public Library of Science

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9910c517275000edb05ec83278b933f7
http://europepmc.org/articles/PMC3862845?pdf=render

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