Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Robert H, Oakley"'
Publikováno v:
Neurobiology of Stress, Vol 28, Iss , Pp 100589- (2024)
Many stress-related neuropsychiatric disorders display pronounced sex differences in their frequency and clinical symptoms. Glucocorticoids are primary stress hormones that have been implicated in the development of these disorders but whether they c
Externí odkaz:
https://doaj.org/article/e7dd9677251141698fad4c81d5073831
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-13 (2022)
Abstract Bcl-2 is an anti-apoptotic protein that promotes cell survival and resistance to cell death. Predictably, Bcl-2 as well as other anti-apoptotic Bcl-2 family members have been found to be overexpressed in a variety of human cancers. Approache
Externí odkaz:
https://doaj.org/article/1d6d6b6107bc4e43abb337ce19cbc7e6
Autor:
Pablo Ruiz, Paul Gabarre, Camille Chenevier-Gobeaux, Hélène François, Mathieu Kerneis, John A. Cidlowski, Robert H. Oakley, Guillaume Lefèvre, Mathieu Boissan
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
BackgroundTakotsubo syndrome is an acute cardiac condition usually involving abnormal regional left ventricular wall motion and impaired left ventricular contractility. It is due mainly to hyper-stimulation of the sympathetic nerve system, inducing a
Externí odkaz:
https://doaj.org/article/431cd91039864eb4b51952ae1357c5a7
Autor:
Jonathan T. Busada, Stuti Khadka, Kylie N. Peterson, Sara R. Druffner, Deborah J. Stumpo, Lecong Zhou, Robert H. Oakley, John A. Cidlowski, Perry J. Blackshear
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1831-1845 (2021)
Background & Aims: Aberrant immune activation is associated with numerous inflammatory and autoimmune diseases and contributes to cancer development and progression. Within the stomach, inflammation drives a well-established sequence from gastritis t
Externí odkaz:
https://doaj.org/article/876709e33caf46139fe9a9eaa46c5efb
Autor:
Carlos Perez Kerkvliet, Amy R. Dwyer, Caroline H. Diep, Robert H. Oakley, Christopher Liddle, John A. Cidlowski, Carol A. Lange
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-23 (2020)
Abstract Background Altered signaling pathways typify breast cancer and serve as direct inputs to steroid hormone receptor sensors. We previously reported that phospho-Ser134-GR (pS134-GR) species are elevated in triple-negative breast cancer (TNBC)
Externí odkaz:
https://doaj.org/article/1efbfc0a8b594b1c995949a1dcd4afbd
Autor:
Shuang Tang, Zhan Zhang, Robert H. Oakley, Wenling Li, Weijing He, Xiaojiang Xu, Ming Ji, Qing Xu, Liang Chen, Alicia S. Wellman, Qingguo Li, Leping Li, Jian-Liang Li, Xinxiang Li, John A. Cidlowski, Xiaoling Li
Publikováno v:
JCI Insight, Vol 6, Iss 24 (2021)
Synthetic immunosuppressive glucocorticoids (GCs) are widely used to control inflammatory bowel disease (IBD). However, the impact of GC signaling on intestinal tumorigenesis remains controversial. Here, we report that intestinal epithelial GC recept
Externí odkaz:
https://doaj.org/article/d06457a96cc14c058b9364939e139e71
Autor:
Robert H. Oakley, Shannon D. Whirledge, Maria G. Petrillo, Natallia V. Riddick, Xiaojiang Xu, Sheryl S. Moy, John A. Cidlowski
Publikováno v:
Neurobiology of Stress, Vol 15, Iss , Pp 100369- (2021)
Chronic stress contributes to numerous human pathologies including cognition impairments and psychiatric disorders. Glucocorticoids are primary stress hormones that activate two closely related nuclear receptors, the glucocorticoid (GR) and mineraloc
Externí odkaz:
https://doaj.org/article/d6c2a837db574f9fa56b9265a2711497
Autor:
Hemangini A. Dhaibar, Natalie G. Carroll, Shripa Amatya, Lilly Kamberov, Pranshu Khanna, A. Wayne Orr, Steven R. Bailey, Robert H. Oakley, John A. Cidlowski, Diana Cruz‐Topete
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 17 (2021)
Background Stress has emerged as an important risk factor for heart disease in women. Stress levels have been shown to correlate with delayed recovery and increased mortality after a myocardial infarction. Therefore, we sought to investigate if the o
Externí odkaz:
https://doaj.org/article/85ae279a50e04464afa4209cb76289ef
Autor:
Macarena Tejos-Bravo, Robert H. Oakley, Shannon D. Whirledge, Wladimir A. Corrales, Juan P. Silva, Gonzalo García-Rojo, Jorge Toledo, Wendy Sanchez, Luciano Román-Albasini, Esteban Aliaga, Felipe Aguayo, Felipe Olave, Vinicius Maracaja-Coutinho, John A. Cidlowski, Jenny L. Fiedler
Publikováno v:
Neurobiology of Stress, Vol 14, Iss , Pp 100306- (2021)
Sex differences in the brain have prompted many researchers to investigate the underlying molecular actors, such as the glucocorticoid receptor (GR). This nuclear receptor controls gene expression, including microRNAs (miRNAs), in non-neuronal cells.
Externí odkaz:
https://doaj.org/article/551a49ab2e4540a89888e32663403077
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
A decline in normal physiological functions characterizes the aging process. While some of these changes are benign, the decrease in the function of the cardiovascular system that occurs during aging leads to the activation of pathological processes
Externí odkaz:
https://doaj.org/article/6d44e15fc8c94714b8e8d7f652458993