Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Robert H, Newman"'
Autor:
Anthony E. Postiglione, Laquaundra L. Adams, Ese S. Ekhator, Anuoluwapo E. Odelade, Supriya Patwardhan, Meenal Chaudhari, Avery S. Pardue, Anjali Kumari, William A. LeFever, Olivia P. Tornow, Tamer S. Kaoud, Johnathan Neiswinger, Jun Seop Jeong, Derek Parsonage, Kimberly J. Nelson, Dukka B. Kc, Cristina M. Furdui, Heng Zhu, Andrew J. Wommack, Kevin N. Dalby, Ming Dong, Leslie B. Poole, Jeremiah D. Keyes, Robert H. Newman
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107817- (2023)
Summary: Extracellular signal-regulated kinases 1 and 2 (ERK1/2) are dysregulated in many pervasive diseases. Recently, we discovered that ERK1/2 is oxidized by signal-generated hydrogen peroxide in various cell types. Since the putative sites of oxi
Externí odkaz:
https://doaj.org/article/f86f308d6824464da8ac7565dac3a50d
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Protein succinylation is an important post-translational modification (PTM) responsible for many vital metabolic activities in cells, including cellular respiration, regulation, and repair. Here, we present a novel approach that combines fea
Externí odkaz:
https://doaj.org/article/05ba5159bed749beae6d1133d9a0744b
Publikováno v:
ACS Omega, Vol 6, Iss 43, Pp 29166-29170 (2021)
Externí odkaz:
https://doaj.org/article/be721524c99a452590129357eac401bc
Autor:
Jeannette Delva-Wiley, Ese S. Ekhator, Laquaundra L. Adams, Supriya Patwardhan, Ming Dong, Robert H. Newman
Publikováno v:
Life, Vol 13, Iss 9, p 1811 (2023)
The cyclic AMP-dependent protein kinase (PKA) plays an essential role in the regulation of many important cellular processes and is dysregulated in several pervasive diseases, including diabetes, cardiovascular disease, and various neurodegenerative
Externí odkaz:
https://doaj.org/article/dc1df490949b41d4a8ac8201d02cf07b
Autor:
Niraj Thapa, Meenal Chaudhari, Anthony A. Iannetta, Clarence White, Kaushik Roy, Robert H. Newman, Leslie M. Hicks, Dukka B. KC
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Protein phosphorylation, which is one of the most important post-translational modifications (PTMs), is involved in regulating myriad cellular processes. Herein, we present a novel deep learning based approach for organism-specific protein p
Externí odkaz:
https://doaj.org/article/763a7ff34700418ebf40a11c4465bd6e
Autor:
Niraj Thapa, Meenal Chaudhari, Sean McManus, Kaushik Roy, Robert H. Newman, Hiroto Saigo, Dukka B. KC
Publikováno v:
BMC Bioinformatics, Vol 21, Iss S3, Pp 1-10 (2020)
Abstract Background Protein succinylation has recently emerged as an important and common post-translation modification (PTM) that occurs on lysine residues. Succinylation is notable both in its size (e.g., at 100 Da, it is one of the larger chemical
Externí odkaz:
https://doaj.org/article/4917ff7995944b89bb81b388a0ebb863
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 852-860 (2020)
Malonylation, which has recently emerged as an important lysine modification, regulates diverse biological activities and has been implicated in several pervasive disorders, including cardiovascular disease and cancer. However, conventional global pr
Externí odkaz:
https://doaj.org/article/7a0bf24ab9094152b31055a6f8a13538
Autor:
Niraj Thapa, Meenal Chaudhari, Sean McManus, Kaushik Roy, Robert H. Newman, Hiroto Saigo, Dukka B. KC
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/bfff90fc476949559138d89a3f3ba307
Autor:
Meenal Chaudhari, Niraj Thapa, Hamid Ismail, Sandhya Chopade, Doina Caragea, Maja Köhn, Robert H. Newman, Dukka B. KC
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Phosphorylation, which is mediated by protein kinases and opposed by protein phosphatases, is an important post-translational modification that regulates many cellular processes, including cellular metabolism, cell migration, and cell division. Due t
Externí odkaz:
https://doaj.org/article/4eebbf72686d46dfbd129369cb4b0c41
Autor:
Hussam J. AL-barakati, Evan W. McConnell, Leslie M. Hicks, Leslie B. Poole, Robert H. Newman, Dukka B. KC
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Abstract Protein S-sulfenylation, which results from oxidation of free thiols on cysteine residues, has recently emerged as an important post-translational modification that regulates the structure and function of proteins involved in a variety of ph
Externí odkaz:
https://doaj.org/article/a2f299fb10184e2fa23fde2539f4dae7