Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Robert H, McCusker"'
Autor:
Sultan Tousif, Yong Wang, Joshua Jackson, Kenneth P. Hough, John G. Strenkowski, Mohammad Athar, Victor J. Thannickal, Robert H. McCusker, Selvarangan Ponnazhagan, Jessy S. Deshane
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Regulatory B cells (Breg) are IL-10 producing subsets of B cells that contribute to immunosuppression in the tumor microenvironment (TME). Breg are elevated in patients with lung cancer; however, the mechanisms underlying Breg development and their f
Externí odkaz:
https://doaj.org/article/1942612f213d4139803771b8c0d5424a
Autor:
Lisa A. Wetzel, Myrna Hurtado, Zoe A. MacDowell Kaswan, Robert H. McCusker, Andrew J. Steelman
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 7, Iss , Pp 100116- (2020)
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) with pathological features of inflammation, demyelination, and neurodegeneration. Several lines of evidence suggest that the enzymes indoleamine 2,3-dioxygenase (Ido
Externí odkaz:
https://doaj.org/article/66bfd31d1e484cd4bc4d29271a708041
Autor:
Lijie Zhai, April Bell, Erik Ladomersky, Kristen L. Lauing, Lakshmi Bollu, Jeffrey A. Sosman, Bin Zhang, Jennifer D. Wu, Stephen D. Miller, Joshua J. Meeks, Rimas V. Lukas, Eugene Wyatt, Lynn Doglio, Gary E. Schiltz, Robert H. McCusker, Derek A. Wainwright
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Indoleamine 2, 3-dioxygenase 1 (IDO; IDO1; INDO) is a rate-limiting enzyme that metabolizes the essential amino acid, tryptophan, into downstream kynurenines. Canonically, the metabolic depletion of tryptophan and/or the accumulation of kynurenine is
Externí odkaz:
https://doaj.org/article/739cbe66148b4c3487d236e84486ab82
Autor:
Carlos R. Dostal, Megan Carson Sulzer, Keith W. Kelley, Gregory G. Freund, Robert H. McCusker
Publikováno v:
Neurobiology of Stress, Vol 7, Iss , Pp 1-15 (2017)
Stressors activate the hypothalamic-pituitary-adrenal (HPA) axis and immune system eliciting changes in cognitive function, mood and anxiety. An important link between stress and altered behavior is stimulation of the Kynurenine Pathway which generat
Externí odkaz:
https://doaj.org/article/e46528d418ea482496eb60bfbe2cfb20
Autor:
Alexandra K Brooks, Marcus A Lawson, Jennifer L Rytych, Kevin C Yu, Tiffany M Janda, Andrew J Steelman, Robert H McCusker
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
Elevated levels of circulating pro-inflammatory cytokines are associated with symptomology of several psychiatric disorders, notably major depressive disorder. Symptomology has been linked to inflammation/cytokine-dependent induction of the Kynurenin
Externí odkaz:
https://doaj.org/article/e620107f2afb4c94a02034380d2bcf0f
Autor:
Dianelys Gonzalez-Pena, Scott E Nixon, Bruce R Southey, Marcus A Lawson, Robert H McCusker, Alvaro G Hernandez, Robert Dantzer, Keith W Kelley, Sandra L Rodriguez-Zas
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157727 (2016)
Microglia in the brain and macrophages in peripheral organs are cell types responsible for immune response to challenges. Indoleamine 2,3-dioxygenase 1 (IDO1) is an immunomodulatory enzyme of the tryptophan pathway that is expressed in the brain. The
Externí odkaz:
https://doaj.org/article/5e4001792cca421d94510a0c40f93381
Autor:
Dianelys Gonzalez-Pena, Scott E Nixon, Jason C O'Connor, Bruce R Southey, Marcus A Lawson, Robert H McCusker, Tania Borras, Debbie Machuca, Alvaro G Hernandez, Robert Dantzer, Keith W Kelley, Sandra L Rodriguez-Zas
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150858 (2016)
Depression symptoms following immune response to a challenge have been reported after the recovery from sickness. A RNA-Seq study of the dysregulation of the microglia transcriptome in a model of inflammation-associated depressive behavior was undert
Externí odkaz:
https://doaj.org/article/5181b5e3b1f74903ad63b2e1dcade39d
Publikováno v:
Brain, Behavior, and Immunity. 106:25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8784fa2a3657b98136f1e0ff6419e16d
https://doi.org/10.1016/j.bbi.2022.07.089
https://doi.org/10.1016/j.bbi.2022.07.089
Autor:
Gregory G. Freund, Robert H. McCusker, Alexandra K. Brooks, Andrew J. Steelman, Albert E. Towers, M. Juda
Publikováno v:
Epilepsia. 60:626-635
OBJECTIVE Viral encephalitis increases the risk for developing seizures and epilepsy. Indoleamine 2,3-dioxygenase 1 (Ido1) is induced by inflammatory cytokines and functions to metabolize tryptophan to kynurenine. Kynurenine can be further metabolize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38904b817a5a9ed341bb3acf08867a88
https://doi.org/10.1111/epi.14675
https://doi.org/10.1111/epi.14675
Autor:
Robert H. McCusker, Myrna Hurtado, Zoe A. MacDowell Kaswan, Andrew J. Steelman, Lisa A. Wetzel
Publikováno v:
Brain, Behavior, & Immunity-Health, Vol 7, Iss, Pp 100116-(2020)
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) with pathological features of inflammation, demyelination, and neurodegeneration. Several lines of evidence suggest that the enzymes indoleamine 2,3-dioxygenase (Ido
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c83dafa753fd6d8d30a9aa5ba5751078
http://www.sciencedirect.com/science/article/pii/S2666354620300818
http://www.sciencedirect.com/science/article/pii/S2666354620300818