Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Robert Gustavsson"'
Publikováno v:
Sensors, Vol 14, Iss 10, Pp 17864-17882 (2014)
Soft sensors are the combination of robust on-line sensor signals with mathematical models for deriving additional process information. Here, we apply this principle to a microbial recombinant protein production process in a bioreactor by exploiting
Externí odkaz:
https://doaj.org/article/ee78077c70a84fd49e10b31fd03ceb32
Autor:
Thuy Tran, Erik Martinsson, Robert Gustavsson, Otto Tronarp, Mats Nilsson, Kristoffer Rudenholm Hansson, Ingemar Lundström, Carl-Fredrik Mandenius, Daniel Aili
Publikováno v:
Analytical methods : advancing methods and applications. 14(44)
Therapeutic monoclonal antibodies (mAbs) provide new means for treatments of a wide range of diseases and comprise a large fraction of all new approved drugs. Production of mAbs is expensive compared to conventional drug production, primarily due to
Autor:
Thuy Tran, Olof Eskilsson, Florian Mayer, Robert Gustavsson, Robert Selegård, Ingemar Lundström, Carl-Fredrik Mandenius, Erik Martinsson, Daniel Aili
A novel nanoplasmonic sensor which facilitate on-line measurement of IgG titershas been developed and evaluated. The developed sensor enablesmeasurement of IgG titer in real-time with an online setup and has great potential to facilitate bioprocess m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd1326bf45a7e396dc789841cb8c8764
Publikováno v:
Processes
Publikováno v:
Journal of biotechnology. 296
Microbial contamination in mammalian cell cultures causing rejected batches is costly and highly unwanted. Most methods for detecting a contamination are time-consuming and require extensive off-line sampling. To circumvent these efforts and provide
Autor:
Robert Gustavsson
In the manufacture of bio-therapeutics the importance of a well-known process is key for a high product titer and low batch to batch variations. Soft sensors are based on the concept that online sensor signals can be used as inputs to mathematical mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38ba86929f45f3c2bbefc8298fb4344e
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-152439
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-152439
Publikováno v:
Journal of Biotechnology. 200:44-51
The feeding of a fed-batch cultivation producing recombinant protein was controlled by a soft sensor set-up. It was assumed that the control approach could be based on the cell's production of carbon dioxide and that this parameter indicates the meta
Publikováno v:
Journal of Chemical Technology & Biotechnology. 90:215-227
This mini-review discusses how soft sensors can contribute to accomplish FDAs process analytical technology (PAT) ambitions in the manufacture of bio-therapeutics. Focus is on applications with pro ...
Publikováno v:
Journal of Biotechnology. 177:53-59
Model-based operator training simulators (OTS) could be powerful tools for virtual training of operational procedures and skills of production personnel in recombinant protein processes. The applied model should describe critical events in the biopro
Publikováno v:
Bioreactors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f32e5fb54a45acff8113bf757c36fbd
https://doi.org/10.1002/9783527683369.ch14
https://doi.org/10.1002/9783527683369.ch14