Výsledky vyhledávání - "Robert Granet"

Curcumin–cyclodextrin/cellulose nanocrystals improve the phenotype of Charcot-Marie-Tooth-1A transgenic rats through the reduction of oxidative stress

Autor: Martial Caillaud, Laurence Richard, Zeina Msheik, Jean-Michel Vallat, Vincent Sol, Robert Granet, Alexis Desmoulière, Laetitia Vignaud, Franck Sturtz, Gautier M.A. Ndong-Ntoutoume, Pierre-Antoine Faye, Frédéric Favreau, Fabrice Billet

Publikováno v: Free Radical Biology and Medicine
Free Radical Biology and Medicine, Elsevier, 2020, 161, pp.246-262. ⟨10.1016/j.freeradbiomed.2020.09.019⟩

International audience; The most prevalent form of Charcot-Marie-Tooth disease (CMT type 1A) is characterized by duplication of the PMP22 gene, peripheral dysmyelination and decreased nerve conduction velocities leading to muscle weakness. Recently,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca1e7db3bbfacac70e2de2ee9e6d6300
https://hal.archives-ouvertes.fr/hal-03269220

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Design and synthesis of zinc protoporphyrin IX-adamantane/cyclodextrin/cellulose nanocrystals complexes for anticancer photodynamic therapy

Autor: Ludovic Bretin, Frédérique Brégier, Eléna Constantin, Vincent Sol, Jean-Pierre Mbakidi, David Yannick Leger, Vincent Chaleix, Robert Granet, Gautier Mark Arthur Ndong Ntoutoume, Bertrand Liagre

Publikováno v: Bioorganic & Medicinal Chemistry Letters
Bioorganic & Medicinal Chemistry Letters, 2021, 41, pp.128024. ⟨10.1016/j.bmcl.2021.128024⟩

Two protoporphyrin IX (PpIX) adamantane derivatives were synthesized and then metallated with zinc. The Zn-PpIX derivatives, exhibiting a high singlet oxygen quantum yield, were tested for their photodynamic activity against the HT-29 cell line. In o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e85f12caa6d5ed06abc9816a5be4f292
https://doi.org/10.1016/j.bmcl.2021.128024

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Enhancement of hydrosolubility and in vitro antiproliferative properties of chalcones following encapsulation into β-cyclodextrin/cellulose-nanocrystal complexes

Autor: Benjamin Rioux, Catherine Fagnère, Robert Granet, Bertrand Liagre, Aurélie Laurent, Gautier M.A. Ndong-Ntoutoume, Yves Champavier, Aurélie Gamond, Christelle Pouget, Vincent Sol, Aline Pinon

Publikováno v: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2019, 29 (15), pp.1895-1898. ⟨10.1016/j.bmcl.2019.05.056⟩

International audience; This paper describes the preparation of two chalcone/β-cyclodextrin/cellulose-nanocrystals complexes and thestudy of their antiproliferative activities against two colorectal and two prostatic cancer cell lines. The aim of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9193a497c6fdb55cc2189517698e24f2
https://hal-unilim.archives-ouvertes.fr/hal-02922089

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Enhanced cytotoxicity of gold porphyrin complexes after inclusion in cyclodextrin scaffolds adsorbed on polyethyleneimine-coated gold nanoparticles

Autor: Bertrand Liagre, Gautier Mark Arthur Ndong Ntoutoume, René Faure, Robert Granet, Jean Pierre Mbakidi, David Yann Leger, Vincent Sol

Publikováno v: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2019, 29 (9), pp.1065-1068. ⟨10.1016/j.bmcl.2019.03.003⟩

A new gold nanoparticle-based construct has been designed to hydrophobic drugs delivery into cancer cells. Cyclodextrin scaffolds adsorbed on polyethyleneimine-coated gold nanoparticles (AuNP@PEI@CD) have been used to encapsulate hydrophobic tetrapyr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0855f5d032fe94d224af9c7e8f8f8f8a
https://hal-unilim.archives-ouvertes.fr/hal-02922086/file/S0960894X19301337.pdf

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PEI-cellulose nanocrystal hybrids as efficient siRNA delivery agents—Synthesis, physicochemical characterization and in vitro evaluation

Autor: Vincent Sol, Vincent Grassot, Frédérique Brégier, Jean-Michel Petit, Julien Chabanais, Robert Granet, Gautier Mark Arthur Ndong Ntoutoume

Publikováno v: Carbohydrate Polymers
Carbohydrate Polymers, Elsevier, 2017, 164, pp.258-267. ⟨10.1016/j.carbpol.2017.02.004⟩

International audience; We describe the synthesis of cellulose nanocrystals (CNCs) complexed to siRNA. PEI (600 Da) was first covalently attached to CNCs by reductive amination reaction, then CNCs-PEI were loaded with siRNA, resulting in the formatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f9d175337898830edd3c5121b75c291
https://hal-unilim.archives-ouvertes.fr/hal-01738117

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Design and synthesis of water-soluble polyaminated chlorins and bacteriochlorins – With near-infrared absorption

Autor: Vincent Sol, Christelle Gady, Robert Granet, Nicolas Drogat

Publikováno v: Dyes and Pigments
Dyes and Pigments, Elsevier, 2013, 98 (3), pp.609-614. ⟨10.1016/j.dyepig.2013.03.018⟩

To enhance the solubility of two new photosensitizers (PS), obtained from natural products ( Spirulina maxima and Rhodobacter sphaeroides ), derivatization of purpurin-18 1 and bacteriopurpurin-18 3 with a cationic polymer: PEI (polyethylenimine) led

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3241b7cada8a27a2462f63b041949aa6
https://doi.org/10.1016/j.dyepig.2013.03.018

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Hydrophilic chlorin-conjugated magnetic nanoparticles—Potential anticancer agent for the treatment of melanoma by PDT

Autor: Marie-Hélène Ratinaud, Jean Pierre Mbakidi, Tan-Sothea Ouk, Vincent Sol, Nicolas Drogat, Eric Rivière, Mireille Verdier, Robert Granet

Publikováno v: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2013, 23 (9), pp.2486-90. ⟨10.1016/j.bmcl.2013.03.039⟩

International audience; This Letter reports the synthesis and the characterization of two new water-stable and soluble photosensitizer-conjugated magnetic nanoparticles (PS-MNPs) composed of an iron oxide magnetic core coated with a biocompatible dex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8539409f487d4ed39497be367b82f9
https://doi.org/10.1016/j.bmcl.2013.03.039

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Analysis of the in vitro and in vivo effects of photodynamic therapy on prostate cancer by using new photosensitizers, protoporphyrin IX-polyamine derivatives

Autor: Guillaume Chemin, David Yannick Leger, Robert Granet, Claude-Yves Couquet, Chloë Fidanzi-Dugas, Claire Carrion, Bertrand Liagre, Vincent Sol, Aurélie Perraud

Publikováno v: Biochimica et Biophysica Acta (BBA)-General Subjects
Biochimica et Biophysica Acta (BBA)-General Subjects, Elsevier, 2017, 1861 (7), pp.1676-1690. ⟨10.1016/j.bbagen.2017.02.003⟩

Background Photodynamic therapy, using porphyrins as photosensitizers (PS), has been approved in treatment of several solid tumors. However, commonly used PS induce death but also resistance pathways in cancer cells and an alteration of surrounding n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f4df7aaf8a38a3b13804213cccae37a
https://pubmed.ncbi.nlm.nih.gov/28188858

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Delivery of tanshinone IIA and α-mangostin from gold/PEI/cyclodextrin nanoparticle platform designed for prostate cancer chemotherapy

Autor: Jean-Pierre Mbakidi, Vincent Chaleix, Tan Sothea-Ouk, Frédérique Brégier, Shihong Qiu, Ludovic Micallef, Bertrand Liagre, David Yannick Leger, Christelle Pouget, Vincent Sol, Robert Granet

Publikováno v: Bioorganicmedicinal chemistry letters. 26(10)

A new anti-cancer drug delivery system, based on gold nanoparticles, has been designed for hydrophobic active compounds. The system is a conjugate of gold/polyethyleneimine (AuNPs/PEI) nanoparticles and sulphated β-cyclodextrin (CD). Anionic cyclode

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300ffc9172a810d63117ff05c3a8cb24
https://pubmed.ncbi.nlm.nih.gov/27040657

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Development of curcumin-cyclodextrin/cellulose nanocrystals complexes: New anticancer drug delivery systems

Autor: David Yannick Leger, Frédérique Brégier, Vincent Sol, Vincent Lequart, Robert Granet, Bertrand Liagre, Chloë Fidanzi-Dugas, Vincent Chaleix, Gautier Mark Arthur Ndong Ntoutoume, Nicolas Joly, Jean-Pierre Mbakidi

Publikováno v: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2016, 26, pp.941-945. ⟨10.1016/j.bmcl.2015.12.060⟩

International audience; The synthesis of curcumin-cyclodextrin/cellulose nanocrystals (CNCx) nano complexes was performed. CNCx were functionalized by ionic association with cationic β-cyclodextrin (CD) and CD/CNCx complexes were used to encapsulate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad3f9ab4917dbbf50acdb15d08885f5f
https://hal-unilim.archives-ouvertes.fr/hal-01257118

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