Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Robert Goldstone"'
Autor:
Panayiotis Anastasiou, Christopher Moore, Sareena Rana, Mona Tomaschko, Claire E. Pillsbury, Andrea de Castro, Jesse Boumelha, Edurne Mugarza, Sophie de Carné Trécesson, Ania Mikolajczak, Cristina Blaj, Robert Goldstone, Jacqueline A. M. Smith, Elsa Quintana, Miriam Molina-Arcas, Julian Downward
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Mutant selective drugs targeting the inactive, GDP-bound form of KRASG12C have been approved for use in lung cancer, but resistance develops rapidly. Here we use an inhibitor, (RMC-4998) that targets RASG12C in its active, GTP-bound form, to
Externí odkaz:
https://doaj.org/article/f04ce583c0fc4b438b6298469e1bd117
Autor:
Simeon R. Mihaylov, Lydia M. Castelli, Ya-Hui Lin, Aytac Gül, Nikita Soni, Christopher Hastings, Helen R. Flynn, Oana Păun, Mark J. Dickman, Ambrosius P. Snijders, Robert Goldstone, Oliver Bandmann, Tatyana A. Shelkovnikova, Heather Mortiboys, Sila K. Ultanir, Guillaume M. Hautbergue
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract PGC-1α plays a central role in maintaining mitochondrial and energy metabolism homeostasis, linking external stimuli to transcriptional co-activation of genes involved in adaptive and age-related pathways. The carboxyl-terminus encodes a se
Externí odkaz:
https://doaj.org/article/d4c65c08085643d58fc9598614996598
Autor:
Hermaleigh Townsley, Joshua Gahir, Timothy W Russell, David Greenwood, Edward J Carr, Matala Dyke, Lorin Adams, Murad Miah, Bobbi Clayton, Callie Smith, Mauro Miranda, Harriet V Mears, Chris Bailey, James R M Black, Ashley S Fowler, Margaret Crawford, Katalin Wilkinson, Matthew Hutchinson, Ruth Harvey, Nicola O'Reilly, Gavin Kelly, Robert Goldstone, Rupert Beale, Padmasayee Papineni, Tumena Corrah, Richard Gilson, Simon Caidan, Jerome Nicod, Steve Gamblin, George Kassiotis, Vincenzo Libri, Bryan Williams, Sonia Gandhi, Adam J Kucharski, Charles Swanton, David L V Bauer, Emma C Wall
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0294897 (2024)
BackgroundSARS-CoV-2 variant Omicron rapidly evolved over 2022, causing three waves of infection due to sub-variants BA.1, BA.2 and BA.4/5. We sought to characterise symptoms and viral loads over the course of COVID-19 infection with these sub-varian
Externí odkaz:
https://doaj.org/article/95e0348e63df41608cfccc1b745cbb54
Autor:
Marianna Ioannou, Dennis Hoving, Iker Valle Aramburu, Mia I. Temkin, Nathalia M. De Vasconcelos, Theodora-Dorita Tsourouktsoglou, Qian Wang, Stefan Boeing, Robert Goldstone, Spyros Vernardis, Vadim Demichev, Markus Ralser, Sascha David, Klaus Stahl, Christian Bode, Venizelos Papayannopoulos
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-24 (2022)
Hyperinflammation and immune dysfunction are key drivers of immunopathology in sepsis. Here the authors show microbial exploitation of phagocytic receptors is linked to triggering of sepsis and the immune cell mediated reduction in neutrophil life sp
Externí odkaz:
https://doaj.org/article/16a60dd84fd94a0a9691874f1193e9ac
Extensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture
Autor:
Michael Lattke, Robert Goldstone, James K. Ellis, Stefan Boeing, Jerónimo Jurado-Arjona, Nicolás Marichal, James I. MacRae, Benedikt Berninger, Francois Guillemot
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Astrocytes have functions crucial for brain homeostasis, which are disrupted in many neurological disorders, but how these functions are established during astrocyte maturation is largely unknown. Here the authors show transcriptional and chromatin c
Externí odkaz:
https://doaj.org/article/798f138617cc451ba7602ca0f438bd2d
Autor:
Michael D. Buck, Enzo Z. Poirier, Ana Cardoso, Bruno Frederico, Johnathan Canton, Sam Barrell, Rupert Beale, Richard Byrne, Simon Caidan, Margaret Crawford, Laura Cubitt, Sonia Gandhi, Robert Goldstone, Paul R. Grant, Kiran Gulati, Steve Hindmarsh, Michael Howell, Michael Hubank, Rachael Instrell, Ming Jiang, George Kassiotis, Wei-Ting Lu, James I. MacRae, Iana Martini, Davin Miller, David Moore, Eleni Nastouli, Jerome Nicod, Luke Nightingale, Jessica Olsen, Amin Oomatia, Nicola O'Reilly, Anett Rideg, Ok-Ryul Song, Amy Strange, Charles Swanton, Samra Turajlic, Mary Wu, Caetano Reis e Sousa, The Crick COVID-19 Consortium
Publikováno v:
Wellcome Open Research, Vol 6 (2021)
The ongoing pandemic of SARS-CoV-2 calls for rapid and cost-effective methods to accurately identify infected individuals. The vast majority of patient samples is assessed for viral RNA presence by RT-qPCR. Our biomedical research institute, in colla
Externí odkaz:
https://doaj.org/article/5ae84b910d3947409230776bdb593363
Autor:
Simon Butterworth, Kristina Kordova, Sambamurthy Chandrasekaran, Kaitlin K. Thomas, Francesca Torelli, Eloise J. Lockyer, Amelia Edwards, Robert Goldstone, Anita A. Koshy, Moritz Treeck
SUMMARYIntracellular pathogens and other endosymbionts reprogram host cell transcription to suppress immune responses and recalibrate biosynthetic pathways. This reprogramming is critical in determining the outcome of infection or colonisation. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2d8fd50783c2d55a5b7a556cbfdc0fb
https://doi.org/10.1101/2023.04.21.537779
https://doi.org/10.1101/2023.04.21.537779
Autor:
Jesse Boumelha, Andrea de Castro, Nourdine Bah, Hongui Cha, Sophie de Carné Trécesson, Sareena Rana, Panayiotis Anastasiou, Edurne Mugarza, Christopher Moore, Robert Goldstone, Phil East, Kevin Litchfield, Se-Hoon Lee, Miriam Molina-Arcas, Julian Downward
Oncogenic KRAS impairs anti-tumour immune responses, but effective strategies to combine KRAS inhibitors and immunotherapies have so far proven elusive. In vivo CRISPR-Cas9 screening in an immunogenic murine lung cancer model identifies mechanisms by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c672d746fcfa1e56f0135765efec632
https://doi.org/10.1101/2023.04.13.536740
https://doi.org/10.1101/2023.04.13.536740
Autor:
Robert Goldstone
Publikováno v:
Current Directions in Psychological Science. 31:3-11
Our lives are being measured in rapidly increasing ways and frequency. These measurements have beneficial and deleterious effects at both individual and social levels. Behavioral measurement technologies offer the promise of helping us to know oursel
Autor:
Oana Păun, Yu Xuan Tan, Harshil Patel, Stephanie Strohbuecker, Avinash Ghanate, Clementina Cobolli-Gigli, Miriam Llorian Sopena, Lina Gerontogianni, Robert Goldstone, Siew-Lan Ang, François Guillemot, Cristina Dias
Pioneer transcription factors are thought to play pivotal roles in developmental processes by binding nucleosomal DNA to activate gene expression, though mechanisms through which pioneer transcription factors remodel chromatin remain unclear. Here, u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c063b4526b102f3f520e850c1bfb805