Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Robert Gnügge"'
Autor:
Lorenzo Galanti, Martina Peritore, Robert Gnügge, Elda Cannavo, Johannes Heipke, Maria Dilia Palumbieri, Barbara Steigenberger, Lorraine S. Symington, Petr Cejka, Boris Pfander
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract DNA double-strand breaks (DSBs) can be repaired by several pathways. In eukaryotes, DSB repair pathway choice occurs at the level of DNA end resection and is controlled by the cell cycle. Upon cell cycle-dependent activation, cyclin-dependen
Externí odkaz:
https://doaj.org/article/8bcb57ff610c4ff79e3b5f638390ffcf
Autor:
Robert Gnügge, Lorraine S. Symington
Publikováno v:
Curr Opin Genet Dev
Exposure to environmental mutagens but also cell-endogenous processes can create DNA double-strand breaks (DSBs) in a cell's genome. DSBs need to be repaired accurately and timely to ensure genomic integrity and cell survival. One major DSB repair me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f150e874e271cbca1e3e4fc22a4e6b
https://doi.org/10.1016/j.gde.2021.07.004
https://doi.org/10.1016/j.gde.2021.07.004
Publikováno v:
Molecular Cell. 83:1237-1250.e15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::447b7c5205de4e5f20268737f365ddf1
https://doi.org/10.1016/j.molcel.2023.02.010
https://doi.org/10.1016/j.molcel.2023.02.010
Autor:
Lorraine S. Symington, Ethan J. Sanford, William J. Comstock, Vitor M. Faça, Marcus B. Smolka, Stephanie C. Vega, Robert Gnügge
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
EMBO J
Universidade de São Paulo (USP)
instacron:USP
EMBO J
The Mec1/ATR kinase is crucial for genome maintenance in response to a range of genotoxic insults, but it remains unclear how it promotes context-dependent signaling and DNA repair. Using phosphoproteomic analyses, we uncovered a distinctive Mec1/ATR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33c1e40b6800f7344f131d0cf5599de4
Autor:
Lorraine S. Symington, Robert Gnügge
Publikováno v:
Nucleic Acids Research
DNA double-strand breaks (DSBs) are common genome lesions that threaten genome stability and cell survival. Cells use sophisticated repair machineries to detect and heal DSBs. To study DSB repair pathways and associated factors, inducible site-specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b450c612db6ea63988a78b938d1985
https://pubmed.ncbi.nlm.nih.gov/33053188
https://pubmed.ncbi.nlm.nih.gov/33053188
Autor:
Robert Gnügge, Fabian Rudolf
Publikováno v:
Yeast. 34:205-221
Yeast shuttle vectors are indispensable tools in yeast research. They enable cloning of defined DNA sequences in Escherichia coli and their direct transfer into Saccharomyces cerevisiae cells. There are three types of commonly used yeast shuttle vect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4772203ecdfbf6c84ca8966d2b19e914
https://doi.org/10.1002/yea.3228
https://doi.org/10.1002/yea.3228
Publikováno v:
Yeast. 33:83-98
Shuttle vectors allow for an efficient transfer of recombinant DNA into yeast cells and are widely used in fundamental research and biotechnology. While available shuttle vectors are applicable in many experimental settings, their use in quantitative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9eeea7190bb54d0f80d6f36d5e1abd76
https://doi.org/10.1002/yea.3144
https://doi.org/10.1002/yea.3144
Publikováno v:
Methods in enzymology. 600
Single-stranded DNA (ssDNA) intermediates are essential for homology-dependent repair of DNA double-strand breaks (DSBs) and for the DNA damage response. Here we describe methods routinely used to identify ssDNA intermediates formed by end processing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::215651a00d72899d9c5443625417d5e1
https://pubmed.ncbi.nlm.nih.gov/29458754
https://pubmed.ncbi.nlm.nih.gov/29458754
Single-stranded DNA (ssDNA) intermediates are essential for homology-dependent repair of DNA double-strand breaks (DSBs) and for the DNA damage response. Here we describe methods routinely used to identify ssDNA intermediates formed by end processing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8335fa68e07fa2d09ee63ed5aec371c3
https://doi.org/10.1016/bs.mie.2017.11.007
https://doi.org/10.1016/bs.mie.2017.11.007
Autor:
Robert Gnügge, Lorraine S. Symington
The yeast Mre11–Rad50–Xrs2 (MRX) complex and Sae2 function together to initiate DNA end resection, an essential early step in homology-dependent repair of DNA double-strand breaks (DSBs). In this issue of Genes & Development, Wang and colleagues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::709ca26d1b64d1fbdc02dd1a212f9bf8
https://europepmc.org/articles/PMC5795777/
https://europepmc.org/articles/PMC5795777/