Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Robert George Whittaker"'
Autor:
Qi Yang, Ross A. Davey, Mary W. Davey, Craig L. Francis, Robert George Whittaker, Xanthe E Wells, Minoo J. Moghaddam, Hua-Ming Williams, Fred Widmer, Karen V Cullen
Publikováno v:
British Journal of Pharmacology. 137:1280-1286
1. Increasing the lipophilicity is a strategy often used to improve a compound's cellular uptake and retention but this may also convert it into a substrate for an ATP-dependent transporter such as P-glycoprotein or the multidrug resistance-associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0586b78f194d921f31d808d050901d79
https://doi.org/10.1038/sj.bjp.0704983
https://doi.org/10.1038/sj.bjp.0704983
Autor:
Julie M Fraser, Fred Widmer, Qi Yang, Maree O'Sullivan, Clayton E Walton, Craig L. Francis, Xanthe E Wells, Catherine Walker, Robert George Whittaker
Publikováno v:
Journal of Drug Targeting. 10:479-487
Tris-lipidation uses Tris to produce drug-fatty acyl conjugates. Radiolabelled Tris-fatty acyl conjugates of methotrexate (MTX) were examined in biodistribution studies in BALB/c mice. Following delivery via a variety of routes, the Tris-lipidated co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c24a33d14420f30baaf757522aa46d27
https://doi.org/10.1080/1061186021000038335
https://doi.org/10.1080/1061186021000038335
Autor:
Michael K. Manthey, Wayne Gerrard Reilly, Robert George Whittaker, Qi Yang, Minoo Moghaddam, Fiona Helen Cameron, J Johnston, Craig L. Francis, Xanthe E Wells, Trevor Lockett, K Smith
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 27:563-567
SUMMARY 1. One of the major challenges in the development of pharmaceuticals is their formulation with other materials to give them the desired bioavailability profile when administered into the body. 2. We have developed a flexible platform technolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c41ac8efeabb768b5e082f71457a6916
https://doi.org/10.1046/j.1440-1681.2000.03294.x
https://doi.org/10.1046/j.1440-1681.2000.03294.x
Publikováno v:
Clinical & Experimental Allergy. 30:571-576
Background Pollens are important triggers for allergic asthma and seasonal rhinitis. We have recently reported that proteases released by major allergenic pollens can injure airway epithelial cells in vitro. Disruption of epithelial integrity by prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a0b59d847edf987e02facdb6b092773
https://doi.org/10.1046/j.1365-2222.2000.00784.x
https://doi.org/10.1046/j.1365-2222.2000.00784.x
Autor:
Michael K. Manthey, Wayne Gerrard Reilly, Minoo J. Moghaddam, Vera J. Bender, Craig L. Francis, Xanthe E Wells, Hua Ming He-Williams, Robert George Whittaker
Publikováno v:
Drug Development Research. 46:302-308
The technology described in this article utilises the common laboratory reagent tris to readily produce drug–fatty acid conjugates. Tris has structural similarities to glycerol, allowing the coupling of one to three fatty acyl groups giving compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40b1d2e5473ee8e9c75dc703eaad8dfb
https://doi.org/10.1002/(sici)1098-2299(199903/04)46:3/4<302::aid-ddr16>3.0.co
https://doi.org/10.1002/(sici)1098-2299(199903/04)46:3/4<302::aid-ddr16>3.0.co
Autor:
Kate Silburn, Wayne Gerrard Reilly, Michael K. Manthey, Pantelis Poumbourios, Dale A. McPhee, Anne L. Maerz, Robert George Whittaker, Cyril C. Curtain, Alan Kirkpatrick
Publikováno v:
AIDS Research and Human Retroviruses. 14:385-392
Contrary to earlier reports, we have found that tri- and hexapeptides analogous or homologous with segments of the 23-residue N-terminal fusion sequence (FS) of the viral transmembrane glycoprotein gp41 (residues 517-539) did not significantly inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff5068a845be5eed1fa1a1ae4ab4d9f
https://doi.org/10.1089/aid.1998.14.385
https://doi.org/10.1089/aid.1998.14.385
Autor:
Lloyd D. Graham, Philip A. Jennings, Paul A. Schober, Robert George Whittaker, Kevin D. Haggett, Patricia J. Hayes
Publikováno v:
Annals of the New York Academy of Sciences. 750:10-14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe6dcc18e5eccb5a3dd5e0522f780183
https://doi.org/10.1111/j.1749-6632.1995.tb19917.x
https://doi.org/10.1111/j.1749-6632.1995.tb19917.x
Publikováno v:
Archives of Biochemistry and Biophysics. 314:132-141
A procedure is described for purifying alpha-lytic protease and its mutants from culture supernatants of recombinant Escherichia coli. The method affords substantial amounts (approx. 80 mg) of homogeneous enzyme. We compared the cleavage preferences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::851f711f89670c3f25bd232c38efca2c
https://doi.org/10.1006/abbi.1994.1421
https://doi.org/10.1006/abbi.1994.1421
Publikováno v:
Biotechnology Techniques. 8:203-208
A single-step procedure is described for purifying α-lytic protease and its mutants on a small scale (approx. 5mg) from cell-free supernatants of recombinant E. coli. Although free of non-enzyme protein, these preparations often contain fragments th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26ac8f99c98ce8611903a2f9bfadca62
https://doi.org/10.1007/bf00161591
https://doi.org/10.1007/bf00161591
Publikováno v:
Biotechnology Letters. 16:51-56
We report simple fermentation conditions for high-level extracellular production of α-lytic protease and its mutants by recombinantE. coli. Although transcription was controlled by thelac promoter, addition of the inducer isopropyl-s-D-thiogalactopy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4344ac7f28d9284db5692feb5dc9875b
https://doi.org/10.1007/bf01022623
https://doi.org/10.1007/bf01022623