Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Robert Gastpar"'
Publikováno v:
The Journal of Immunology. 175:2900-2912
IFN-γ exhibits differential effects depending on the target and can induce cellular activation and enhance survival or mediate cell death via activation of apoptotic pathways. In this study, we demonstrate an alternative mechanism by which IFN-γ en
Autor:
Gabriele Multhoff, Josef A. Schroeder, Alexzander Asea, Catharina C. Gross, Maria A. Bausero, Mathias Gehrmann, Robert Gastpar
Publikováno v:
Cancer Research. 65:5238-5247
Detergent-soluble membrane vesicles are actively released by human pancreas (Colo−/Colo+) and colon (CX−/CX+) carcinoma sublines, differing in their capacity to present heat shock protein 70 (Hsp70)/Bag-4 on their plasma membranes. Floating prope
Autor:
Karin Pfister, Stefan W. Krause, Robert Gastpar, Catharina C. Gross, Gerald Thonigs, Gabriele Multhoff, Heidrun Ullrich, Reinhard Andreesen
Publikováno v:
Clinical Cancer Research. 10:3699-3707
Purpose: The 14 amino acid sequence (aa450–463) TKDNNLLGRFELSG (TKD) of heat shock protein 70 (Hsp70) was identified as a tumor-selective recognition structure for natural killer (NK) cells. Incubation of peripheral blood lymphocyte cells with TKD
Autor:
Anna Brandl, Rolf D. Issels, Elisabeth Kremmer, Robert Gastpar, Valeria Milani, Stuart K. Calderwood, Alexzander Asea, Elfriede Noessner, Peter Hutzler, Miriam Roos, Maria C. Kuppner
Publikováno v:
Europe PubMed Central
Scopus-Elsevier
Scopus-Elsevier
Our study demonstrates that tumor-derived heat shock protein (HSP)70 chaperones a tyrosinase peptide and mediates its transfer to human immature dendritic cells (DCs) by receptor-dependent uptake. Human tumor-derived HSP70 peptide complexes (HSP70-PC
Autor:
Robert Gastpar, Susanne Alban
Publikováno v:
SLAS Discovery. 6:393-400
A sulfated polysaccharide-coating enzyme-linked immunosorbent assay (SPC-ELISA), a new screening assay for the study of interactions between sulfated polysaccharides and proteins, has been developed. Fibrinogen was used as representative for the prot
Autor:
Elfriede Nössner, Rolf D. Issels, Robert Gastpar, Maria C. Kuppner, Oswin Ochmann, Anabel Scharner, Svetlana Gelwer
Publikováno v:
European Journal of Immunology. 31:1602-1609
Members of the heat shock protein (hsp70) family are either constitutively expressed (hsc70) or can be induced by hyperthermic stress (hsp70). Recombinant hsp70 (rhsp70) stimulates cytokine production from monocytes and enhances NK cell proliferation
Autor:
Susanne Alban, Robert Gastpar
Publikováno v:
Thrombosis and Haemostasis. 85:824-829
SummaryThe release of circulating tissue factor pathway inhibitor (TFPI) into plasma by heparins is thought to contribute to their overall anti-thrombotic activity. In the presented study in healthy volunteers, we measured the heparin-induced increas
Publikováno v:
Journal of Medicinal Chemistry. 41:4965-4972
The aim of this study was the identification of the essential structural elements in the 12-formyl-5,6-dihydroindolo[2, 1-a]isoquinoline system required for the inhibition of tubulin polymerization which is understood to be the predominant mode of ac
Autor:
Tsuyuki Nishino, Doris Kaufmann, Przemyslaw Reszka, Robert Gastpar, Michaela Pojarová, Patrick J. Bednarski, Erwin von Angerer
Publikováno v:
Bioorganicmedicinal chemistry. 15(23)
Cell cycle arrest of malignant cells is an important option for cancer treatment. In this study, we modified the structure of antimitotic 2-phenylindole-3-carbaldehydes by condensation with malononitrile. The resulting methylene propanedinitriles inh
Autor:
Erwin von Angerer, Robert Gastpar, Doris Kaufmann, Renate Liebl, Tobias Pfaller, Susanne Vogel, Dietmar Gross, Tsuyuki Nishino, Michaela Pojarová
Publikováno v:
Bioorganicmedicinal chemistry. 15(15)
Small molecules such as indoles are attractive as inhibitors of tubulin polymerization. Thus a number of 2-phenylindole-3-carbaldehydes with lipophilic substituents in both aromatic rings was synthesized and evaluated for antitumor activity in MDA-MB