Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Robert G. Newcomer"'
1
Alteration in protein expression in estrogen receptor alpha-negative human breast cancer tissues indicates a malignant and metastatic phenotype
Autor: Stephen W. Byers, Suzan M. Semaan, Yan-gao Man, Ziad J. Sahab, Qing-Xiang Amy Sang, Robert G. Newcomer
Publikováno v: Clinical & Experimental Metastasis. 27:493-503
Ductal carcinoma in situ (DCIS) represents the earliest identifiable breast cancer lesion. Disruption of the myoepithelial cell layer and basement membrane is a prerequisite for DCIS to initiate invasion into the stroma. The majority of epithelial ce
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f587f19c0ec6cf610f107a1e1a7c36be
https://doi.org/10.1007/s10585-010-9338-8
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2
ADAM19/Adamalysin 19 Structure, Function, and Role as a Putative Target in Tumors and Inflammatory Diseases
Autor: Qing-Xiang Amy Sang, Robert G. Newcomer, Bin Qi
Publikováno v: Current Pharmaceutical Design. 15:2336-2348
A disintegrin and metalloproteinase 19 (ADAM19, or adamalysin 19) is a cell surface glycoprotein with a signal sequence, a prodomain, a metalloproteinase domain, a disintegrin domain, a cysteine-rich domain, a epidermal growth factor-like domain, a t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61b784c90b9b32d3f044e0288256fe46
https://doi.org/10.2174/138161209788682352
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3
Endometase/Matrilysin-2 in Human Breast Ductal Carcinoma in Situ and Its Inhibition by Tissue Inhibitors of Metalloproteinases-2 and -4
Autor: Hyun I. Park, Sue C. Heffelfinger, Aizhen Xiao, Yun-Ge Zhao, Qing-Xiang Amy Sang, Yan-gao Man, Robert G. Newcomer, Mei Yan
Publikováno v: Cancer Research. 64:590-598
Local disruption of the integrity of both the myoepithelial cell layer and the basement membrane is an indispensable prerequisite for the initiation of invasion and the conversion of human breast ductal carcinoma in situ (DCIS) to infiltrating ductal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f7103826174b558f8ac4e8acdb508e49
https://doi.org/10.1158/0008-5472.can-03-1932
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4
Activation of Pro-gelatinase B by Endometase/Matrilysin-2 Promotes Invasion of Human Prostate Cancer Cells
Autor: Hyun I. Park, Ai Zhen Xiao, Qing-Xiang Amy Sang, Robert G. Newcomer, John Kurhanewicz, Tie-Bang Kang, Haiyen E. Zhau, Mark G. Swanson, Yun Ge Zhao, Leland W.K. Chung
Publikováno v: Journal of Biological Chemistry. 278:15056-15064
This work has explored a putative biochemical mechanism by which endometase/matrilysin-2/matrix metalloproteinase-26 (MMP-26) may promote human prostate cancer cell invasion. Here, we showed that the levels of MMP-26 protein in human prostate carcino
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::254bc98e566480bcf0f2e413c2e65032
https://doi.org/10.1074/jbc.m210975200
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5
Matrix metalloproteinase inhibition in atherosclerosis and stroke
Autor: Mark D. Roycik, Jennifer S. Myers, Qing-Xiang Amy Sang, Robert G. Newcomer
Publikováno v: Current molecular medicine. 13(8)
Matrix metalloproteinases (MMPs) are a family of tightly regulated, zinc-dependent proteases that degrade extracellular matrix (ECM), cell surface, and intracellular proteins. Vascular remodeling, whether as a function of normal physiology or as a co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fef8816a5ac94536a8fb766eb934539
https://pubmed.ncbi.nlm.nih.gov/23865428
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6
Coordinated peak expression of MMP-26 and TIMP-4 in preinvasive human prostate tumor
Autor: Kenneth A. Iczkowski, Seakwoo Lee, Kevin J. Wu, Mark D. Roycik, Winston Tan, Qing-Xiang Amy Sang, Robert G. Newcomer, Kevin K. Desai, Yun Ge Zhao
Publikováno v: Cell research. 16(9)
The identification of novel biomarkers for early prostate cancer diagnosis is highly important because early detection and treatment are critical for the medical management of patients. Disruption in the continuity of both the basal cell layer and ba
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dace9fe1dfb16e165e8508d764fc204a
https://pubmed.ncbi.nlm.nih.gov/16971961
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7
Matrix metalloproteinase inhibitors as prospective agents for the prevention and treatment of cardiovascular and neoplastic diseases
Autor: Martin A. Schwartz, Xuexun Fang, Sara C Monroe, Douglas R. Hurst, Qiang Cao, Qing-Xiang Amy Sang, Robert G. Newcomer, Yonghao Jin, Seakwoo Lee
Publikováno v: Current topics in medicinal chemistry. 6(4)
Acting on a broad spectrum of extracellular, intracellular, and membrane-associated substrates, the matrix metalloproteinases (MMPs) are critical to the biological processes of organisms; when aberrantly expressed, many pathological conditions may be
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::723fa6e7b2f64d3b93cc2b878231b60d
https://pubmed.ncbi.nlm.nih.gov/16611144
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8
Endometase/matrilysin-2 in human breast ductal carcinoma in situ and its inhibition by tissue inhibitors of metalloproteinases-2 and -4: a putative role in the initiation of breast cancer invasion
Autor: Yun-Ge, Zhao, Ai-Zhen, Xiao, Hyun I, Park, Robert G, Newcomer, Mei, Yan, Yan-Gao, Man, Sue C, Heffelfinger, Qing-Xiang Amy, Sang
Publikováno v: Cancer research. 64(2)
Local disruption of the integrity of both the myoepithelial cell layer and the basement membrane is an indispensable prerequisite for the initiation of invasion and the conversion of human breast ductal carcinoma in situ (DCIS) to infiltrating ductal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cafc9c33e63c1ef00477f178b0b5083f
https://pubmed.ncbi.nlm.nih.gov/14744773
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