iCLOTS: open-source, artificial intelligence-enabled software for analyses of blood cells in microfluidic and microscopy-based assays

Autor: Meredith E. Fay, Oluwamayokun Oshinowo, Elizabeth Iffrig, Kirby S. Fibben, Christina Caruso, Scott Hansen, Jamie O. Musick, José M. Valdez, Sally S. Azer, Robert G. Mannino, Hyoann Choi, Dan Y. Zhang, Evelyn K. Williams, Erica N. Evans, Celeste K. Kanne, Melissa L. Kemp, Vivien A. Sheehan, Marcus A. Carden, Carolyn M. Bennett, David K. Wood, Wilbur A. Lam

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Abstract While microscopy-based cellular assays, including microfluidics, have significantly advanced over the last several decades, there has not been concurrent development of widely-accessible techniques to analyze time-dependent microscopy data i

Externí odkaz: https://doaj.org/article/3240155307a64ee7b82312b788ad694a

Smartphone app for non-invasive detection of anemia using only patient-sourced photos

Autor: Robert G. Mannino, David R. Myers, Erika A. Tyburski, Christina Caruso, Jeanne Boudreaux, Traci Leong, G. D. Clifford, Wilbur A. Lam

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)

Anemia has a global prevalence of over 2 billion people and is diagnosed via blood-based laboratory test. Here the authors describe a smartphone app that can estimate hemoglobin levels and detect anemia by analyzing pictures of fingernail beds taken

Externí odkaz: https://doaj.org/article/9f3b81595f9348aaadb5c489593f36b8

The critical role of engineering in the rapid development of COVID-19 diagnostics: Lessons from the RADx Tech Test Verification Core

Autor: Robert G. Mannino, Eric J. Nehl, Sarah Farmer, Amanda Foster Peagler, Maren C. Parsell, Viviana Claveria, David Ku, David S. Gottfried, Hang Chen, Wilbur A. Lam, Oliver Brand

Publikováno v: Science Advances. 9

Engineering plays a critical role in the development of medical devices, and this has been magnified since 2020 as severe acute respiratory syndrome coronavirus 2 swept over the globe. In response to the coronavirus disease 2019, the National Institu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::877a2aadac86abf73758daec09e0672d
https://doi.org/10.1126/sciadv.ade4962

The RADx Tech Test Verification Core and the ACME POCT in the Evaluation of COVID-19 Testing Devices: A Model for Progress and Change

Autor: Robert C. Jerris, Greg S. Martin, Joshua M. Levy, Stacy Heilman, Sarah Farmer, Robert G. Mannino, Pamela D McGuinness, Christina A. Rostad, CaDeidre Washington, John D. Roback, Andrew S. Neish, Maud Mavigner, Claudia R. Morris, Erika A. Tyburski, Leda Bassit, Anuradha Rao, David D. McManus, Kristen Herzegh, Jennifer K. Frediani, Karl Simin, Wilbur A. Lam, Nils Schoof, Mary Ann Picard, Traci Leong, Thanuja Ramachandra, Eugene Rogers, Nathaniel Hafer, Jess M. Ingersoll, Yun F. Wang, Julie Sullivan, Miriam B. Vos, Oliver Brand, Ray Schinazi, Mark D. Gonzalez, David N. Ku, Russell R. Kempker, Viviana Claveria, Beverly Barton Rogers, Annette M. Esper, Janet Figueroa, Frederick Balagadde, Allison Suessmith, Ann Chahroudi, Paulina A. Rebolledo, David S. Gottfried, Cheryl Stone, Rebecca Gore, Anna Wood, Bradley S. Hanberry, Narayana Cheedarla, Bryan Buchholz, Christopher C. Porter, Eric J. Nehl, Sunita Park, Mark D. Griffiths, Nira R. Pollock, Chiara E. Ghezzi, Ainat Koren, Natia Saakadze

Publikováno v: Ieee Open Journal of Engineering in Medicine and Biology
IEEE Open Journal of Engineering in Medicine and Biology, Vol 2, Pp 142-151 (2021)

Faced with the COVID-19 pandemic, the US system for developing and testing technologies was challenged in unparalleled ways. This article describes the multi-institutional, transdisciplinary team of the “RADxSM Tech Test Verification Core” and it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccd63b00093930bf12b5849bc4eb57b6
http://europepmc.org/articles/PMC8118690

A blueprint for academic laboratories to produce SARS-CoV-2 quantitative RT-PCR test kits

Autor: Santi Mestre-Fos, Nicholas V. Hud, Anton S. Petrov, Raquel L. Lieberman, Bettina Bommarius, Kavita R. Matange, Loren Dean Williams, Anton V. Bryksin, Brett M. Barlow, Vinayak Agarwal, Gwendell Thomas, Robert G. Mannino, Pamela Pollet, Jennifer B. Glass, Chieri Ito, Emily G. Saccuzzo, Jessica C. Bowman, Mallory Hazell, Rebecca K. Donegan, Nguyet A. Nguyen, Samantha J. Mascuch, Suneesh C. Karunakaran, Hem R. Thapa, Gary P. Newnam, Andrés J. García, Brooke Rothschild-Mancinelli, Chiamaka T. Obianyor, Carolyn B. Ibberson, Sara Fakhretaha-Aval, Wilbur A. Lam, Liangjun Zhao, Minh Thu H. Ma, Rebecca Guth-Metzler, Julia Kubanek, Petar I. Penev

Publikováno v: Journal of Biological Chemistry

Widespread testing for the presence of the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in individuals remains vital for controlling the COVID-19 pandemic prior to the advent of an effective treatment. Challenges in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c475667bc2d71dfb929e97b52e3b2b8d
https://doi.org/10.1074/jbc.ra120.015434