Zobrazeno 1 - 10
of 544
pro vyhledávání: '"Robert G. Maki"'
Autor:
Kenneth R. Gundle, Karthik Rajasekaran, Jeffrey Houlton, Gary B. Deutsch, Thomas J. Ow, Robert G. Maki, John Pang, Cherie-Ann O. Nathan, Daniel Clayburgh, Jason G. Newman, Elyse Brinkmann, Michael J. Wagner, Seth M. Pollack, Matthew J. Thompson, Ryan J. Li, Vikas Mehta, Bradley A. Schiff, Barry I. Wenig, Paul L. Swiecicki, Alice L. Tang, Jessica L. Davis, Annemieke van Zante, Jessica A. Bertout, Wendy Jenkins, Atticus Turner, Marc Grenley, Connor Burns, Jason P. Frazier, Angela Merrell, Kimberly H. W. Sottero, Jonathan M. J. Derry, Kate C. Gillespie, Bre Mills, Richard A. Klinghoffer
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: Drug development is systemically inefficient. Research and development costs for novel therapeutics average hundreds of millions to billions of dollars, with the overall likelihood of approval estimated to be as low as 6.7% for oncology
Externí odkaz:
https://doaj.org/article/df356ddd88154387999a5c867f337370
Autor:
Steven Attia, Vanessa Bolejack, Kristen N. Ganjoo, Suzanne George, Mark Agulnik, Daniel Rushing, Elizabeth T. Loggers, Michael B. Livingston, Jennifer Wright, Sant P. Chawla, Scott H. Okuno, Denise K. Reinke, Richard F. Riedel, Lara E. Davis, Christopher W. Ryan, Robert G. Maki
Publikováno v:
Cancer Medicine, Vol 12, Iss 2, Pp 1532-1539 (2023)
Abstract Background Regorafenib is one of several FDA‐approved cancer therapies targeting multiple tyrosine kinases. However, there are few subtype‐specific data regarding kinase inhibitor activity in sarcomas. We report results of a single arm,
Externí odkaz:
https://doaj.org/article/124378635bd247fb9b2242a52cc12063
Autor:
Mrinal M. Gounder, Narasimhan P. Agaram, Sally E. Trabucco, Victoria Robinson, Richard A. Ferraro, Sherri Z. Millis, Anita Krishnan, Jessica Lee, Steven Attia, Wassim Abida, Alexander Drilon, Ping Chi, Sandra P. D’ Angelo, Mark A. Dickson, Mary Lou Keohan, Ciara M. Kelly, Mark Agulnik, Sant P. Chawla, Edwin Choy, Rashmi Chugh, Christian F. Meyer, Parvathi A. Myer, Jessica L. Moore, Ross A. Okimoto, Raphael E. Pollock, Vinod Ravi, Arun S. Singh, Neeta Somaiah, Andrew J. Wagner, John H. Healey, Garrett M. Frampton, Jeffrey M. Venstrom, Jeffrey S. Ross, Marc Ladanyi, Samuel Singer, Murray F. Brennan, Gary K. Schwartz, Alexander J. Lazar, David M. Thomas, Robert G. Maki, William D. Tap, Siraj M. Ali, Dexter X. Jin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Comprehensive molecular profiles are required to understand and treat sarcomas, which comprise more than 70 different subtypes. Here, the authors profile the genomic landscape of 7494 sarcomas across 44 histologies using targeted panel sequencing and
Externí odkaz:
https://doaj.org/article/ded28dd2538e4114ba7de3e78b153f38
Autor:
Noah E. Berlow, Rishi Rikhi, Mathew Geltzeiler, Jinu Abraham, Matthew N. Svalina, Lara E. Davis, Erin Wise, Maria Mancini, Jonathan Noujaim, Atiya Mansoor, Michael J. Quist, Kevin L. Matlock, Martin W. Goros, Brian S. Hernandez, Yee C. Doung, Khin Thway, Tomohide Tsukahara, Jun Nishio, Elaine T. Huang, Susan Airhart, Carol J. Bult, Regina Gandour-Edwards, Robert G. Maki, Robin L. Jones, Joel E. Michalek, Milan Milovancev, Souparno Ghosh, Ranadip Pal, Charles Keller
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-23 (2019)
Abstract Background Cancer patients with advanced disease routinely exhaust available clinical regimens and lack actionable genomic medicine results, leaving a large patient population without effective treatments options when their disease inevitabl
Externí odkaz:
https://doaj.org/article/6013cd28c33a417d9d673beb4af0154c
Autor:
Vishruth K. Reddy, Varsha Jain, Robert J. Wilson II, Lee P. Hartner, Mark Diamond, Ronnie A. Sebro, Kristy L. Weber, Robert G. Maki, Jacob E. Shabason
Publikováno v:
Sarcoma, Vol 2021 (2021)
Purpose. Practice patterns for treatment of localized adult pleomorphic rhabdomyosarcoma (PRMS) remain quite variable given its rarity. Current national guidelines recommend management similar to that of other high-grade soft tissue sarcomas (STS), w
Externí odkaz:
https://doaj.org/article/012648b31e68495a81fa1dc2e81b23d3
Autor:
Amanda R. Dancsok, Dongxia Gao, Anna F. Lee, Sonja Eriksson Steigen, Jean-Yves Blay, David M. Thomas, Robert G. Maki, Torsten O. Nielsen, Elizabeth G. Demicco
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Early trials for immune checkpoint inhibitors in sarcomas have delivered mixed results, and efforts to improve outcomes now look to combinatorial strategies with novel immunotherapeutics, including some that target macrophages. To enhance our underst
Externí odkaz:
https://doaj.org/article/9e799c27028b46f5812c8bcc54b10c57
Autor:
Dan Han, Veronica Rodriguez-Bravo, Elizabeth Charytonowicz, Elizabeth Demicco, Josep Domingo-Domenech, Robert G. Maki, Carlos Cordon-Cardo
Publikováno v:
Stem Cell Research, Vol 21, Iss C, Pp 117-123 (2017)
Human leukocyte antigen class I (HLA-I) down-regulation has been reported in many human cancers to be associated with poor clinical outcome. However, its connection to tumor-initiating cells (TICs) remains unknown. In this study, we report that HLA-I
Externí odkaz:
https://doaj.org/article/73d3562a4d3045128bb12f2d7db45bda
Autor:
Vishruth K. Reddy, Varsha Jain, Sriram Venigalla, Vivek Nimgaokar, Ashwin Amurthur, Daniel Y. Lee, Ronnie A. Sebro, Robert G. Maki, Robert J. Wilson, Kristy L. Weber, Jacob E. Shabason
Publikováno v:
Cancers, Vol 13, Iss 5, p 932 (2021)
Background: Definitive local therapy is often utilized in patients with metastatic soft tissue sarcomas (STS) to reduce morbidity associated with local tumor progression. We hypothesize that it is associated with improved overall survival (OS). Metho
Externí odkaz:
https://doaj.org/article/db5092f857c347ac85bbb6ac838b036a
Autor:
Raji Pillai, Garrett Miyada, Earl Hubbell, Robert G. Maki, Margaret A. Leversha, Yaron Turpaz, Manqiu Cao, Guoliang Leon Xing, Kai Wu, Cristina R. Antonescu
Publikováno v:
Cancer Informatics, Vol 6, Pp 59-75 (2008)
We report a method, Expression-Microarray Copy Number Analysis (ECNA) for the detection of copy number changes using Affymetrix Human Genome U133 Plus 2.0 arrays, starting with as little as 5 ng input genomic DNA. An analytical approach was developed
Externí odkaz:
https://doaj.org/article/5f4a98e941614c0d8549f29173a9438a
Autor:
Steven Attia, Scott H. Okuno, Steven I. Robinson, Nicolas P. Webber, Daniel J. Indelicato, Robin L. Jones, Sanjay P. Bagaria, Courtney Sherman, Kevin R. Kozak, Cherise M. Cortese, Thomas MacFarland, Jonathan C. Trent, Robert G. Maki
Publikováno v:
Rare Tumors, Vol 7, Iss 2 (2015)
We report a response to pazopanib in a 69-year-old man with heavily pre-treated metastatic extraosseous Ewing sarcoma in addition to molecular profiling of his tumor. To our knowledge, this case is the earliest to demonstrate activity of an oral mult
Externí odkaz:
https://doaj.org/article/a9ed1c43f28546d5a9033e3861a5828c