Zobrazeno 1 - 10
of 191
pro vyhledávání: '"Robert G. Hawley"'
Autor:
Yong Yean Kim, Berkley E. Gryder, Ranuka Sinniah, Megan L. Peach, Jack F. Shern, Abdalla Abdelmaksoud, Silvia Pomella, Girma M. Woldemichael, Benjamin Z. Stanton, David Milewski, Joseph J. Barchi, John S. Schneekloth, Raj Chari, Joshua T. Kowalczyk, Shilpa R. Shenoy, Jason R. Evans, Young K. Song, Chaoyu Wang, Xinyu Wen, Hsien-Chao Chou, Vineela Gangalapudi, Dominic Esposito, Jane Jones, Lauren Procter, Maura O’Neill, Lisa M. Jenkins, Nadya I. Tarasova, Jun S. Wei, James B. McMahon, Barry R. O’Keefe, Robert G. Hawley, Javed Khan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Fusion-positive rhabdomyosarcoma (FP-RMS) is an aggressive pediatric sarcoma driven primarily by the PAX3-FOXO1 fusion oncogene, for which therapies targeting PAX3-FOXO1 are lacking. Here, we screen 62,643 compounds using an engineered cell
Externí odkaz:
https://doaj.org/article/62fcc583cb83489ca474d4e078b73633
Autor:
Kevin D. Bunting, Robert G. Hawley
Publikováno v:
The Scientific World Journal, Vol 2, Pp 983-995 (2002)
Hematopoietic stem cells (HSCs) are the best studied of the tissue-specific stem cells. By definition, HSCs have long been regarded as restricted to formation of blood cells of both the lymphoid and myeloid lineages. HSCs residing in the bone marrow
Externí odkaz:
https://doaj.org/article/6b8753d5f19545da99a5eddb5f9c9054
Publikováno v:
BioTechniques, Vol 30, Iss 5, Pp 1028-1034 (2001)
Flow cytometric procedures are described to detect a “humanized” version of a new red fluorescent protein (DsRed) from the coral Discosomasp. in conjunction with various combinations of three Aequorea victoria green fluorescent protein (GFP) vari
Externí odkaz:
https://doaj.org/article/b5debcfd537f47b48fe96ce387bcadbc
Autor:
Yong Yean Kim, Robert G. Hawley, Mehal Churiwal, Teresa S. Hawley, Christine N. Evans, Raj Chari, David Milewski, Ranuka Sinniah, Young K. Song, Hsien-Chao Chou, Xinyu Wen, Ying Pang, Jing Wu, Craig J. Thomas, Jun S. Wei, Michele Ceribelli, Javed Khan
Publikováno v:
Cancer Research. 83:3538-3538
Background: Oncogenic fusion genes are attractive therapeutic targets due to their tumor-specific expression and driver roles in cancers. PAX3-FOXO1 (P3F) is the dominant oncogenic driver of fusion-positive rhabdomyosarcoma (FP-RMS) with no targeted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae6a86d9d5eb070b5b3388ff767184cd
https://doi.org/10.1158/1538-7445.am2023-3538
https://doi.org/10.1158/1538-7445.am2023-3538
Autor:
Robert G. Hawley, Yong Yean Kim, Berkley E. Gryder, Young K. Song, Silvia Pomella, Joseph J. Barchi, Javed Khan, Joshua Kowalczyk
Publikováno v:
Cancer Research. 81:47-47
Background: PAX3/7-FOXO1 fusion gene is the major oncogenic driver in fusion positive rhabdomyosarcoma (FP-RMS), a highly aggressive soft tissue sarcoma of childhood. The chimeric gene results from either t(2;13) or t(1;13) translocation and has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92c93bde942c636c45e8a3629a4e72df
https://doi.org/10.1158/1538-7445.am2021-47
https://doi.org/10.1158/1538-7445.am2021-47
Autor:
Robert G. Hawley
Publikováno v:
Exploratory Research and Hypothesis in Medicine. 2:1-5
Large-scale screening has revealed that human hematopoietic cancer cell lines are generally more sensitive to various classes of drugs than cell lines established from solid tumors. A detailed examination of data in the Cancer Therapeutics Response P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbd4503c1e234d237a50f0908a697607
https://doi.org/10.14218/erhm.2017.00022
https://doi.org/10.14218/erhm.2017.00022
Publikováno v:
Neuroscience Letters. 646:30-35
Parkinson's disease (PD) is a common and progressive neurodegenerative disease in which the majority of cases arise sporadically. Sporadic PD is caused by the interactions of genetic and environmental factors. To date, genetic causes for sporadic PD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e99021d4c23ff0389be67adc49454dd
https://doi.org/10.1016/j.neulet.2017.03.007
https://doi.org/10.1016/j.neulet.2017.03.007
Publikováno v:
Neuroscience Letters. 643:22-26
Parkinson's disease (PD) is a common and progressive neurodegenerative disease, including familial and sporadic cases. To date, genetic causes for sporadic PD, majority of PD cases, remain largely unknown. Accumulating evidence indicates that dysfunc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c40eb419d4ea7ded77bc29ffe73ce2e8
https://doi.org/10.1016/j.neulet.2017.02.028
https://doi.org/10.1016/j.neulet.2017.02.028
Publikováno v:
Oncotarget
// Irene Riz 1 , Teresa S. Hawley 2,3 , Jeffrey W. Marsal 1 and Robert G. Hawley 1 1 Department of Anatomy and Regenerative Biology, George Washington University, Washington, DC, USA 2 Flow Cytometry Core Facility, George Washington University, Washi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaf419b3c1b7691f6445b662971026c8
https://doi.org/10.18632/oncotarget.11960
https://doi.org/10.18632/oncotarget.11960
Publikováno v:
Molecular medicine reports. 19(4)
Coronary artery disease (CAD), including acute myocardial infarction (AMI), is a common complex disease; however, the genetic causes remain largely unknown. Recent epidemiological investigations indicated that the incidence of CAD in patients with co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a84cb3639b09e599299e83506bf4d2f
https://pubmed.ncbi.nlm.nih.gov/30720078
https://pubmed.ncbi.nlm.nih.gov/30720078