Who says 'no' to participating in stroke clinical trials and why: an observational study from the Vancouver Stroke Program

Autor: Zoe R. O’Neill, Halina M. Deptuck, Lauren Quong, Genoveva Maclean, Karina Villaluna, Princess King-Azote, Mukul Sharma, Ken Butcher, Robert G. Hart, Thalia S. Field

Publikováno v: Trials, Vol 20, Iss 1, Pp 1-6 (2019)

Abstract Background Successful stroke trials require adequate recruitment. In this observational study, we assessed reasons for refusal to provide informed consent in eligible patients approached for clinical trial participation at the Vancouver Stro

Externí odkaz: https://doaj.org/article/1819b675a72c44aa82a55f728087c5a2

Evaluating Rates of Recurrent Ischemic Stroke Among Young Adults With Embolic Stroke of Undetermined Source: The Young ESUS Longitudinal Cohort Study

Autor: Kanjana S, Perera, Danielle, de Sa Boasquevisque, Purnima, Rao-Melacini, Amanda, Taylor, Anna, Cheng, Graeme J, Hankey, Sarah, Lee, Joan Marti, Fabregas, Sebastian F, Ameriso, Thalia S, Field, Antonio, Arauz, Shelagh B, Coutts, Marcel, Arnold, Robert, Mikulik, Danilo, Toni, Jennifer, Mandzia, Roland C, Veltkamp, Elena, Meseguer, Karl Georg, Haeusler, Robert G, Hart, Helmi, Lutsep

Publikováno v: JAMA Neurology
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

IMPORTANCE Cryptogenic strokes constitute approximately 40% of ischemic strokes in young adults, and most meet criteria for the embolic stroke of undetermined source (ESUS). Two randomized clinical trials, NAVIGATE ESUS and RESPECT ESUS, showed a hig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a20bc174c5fc07ebe66addd06c0375
https://pubmed.ncbi.nlm.nih.gov/35285865

Frequency and Patterns of Brain Infarction in Patients With Embolic Stroke of Undetermined Source: NAVIGATE ESUS Trial

Autor: Mukul Sharma, Eric E. Smith, Lesly A. Pearce, Ashkan Shoamanesh, Kanjana S. Perera, Shelagh B. Coutts, Dorte Damgaard, Sebastian F. Ameriso, Joung-Ho Rha, Boris Modrau, Byung-Woo Yoon, Marina Romano, Steven R. Messé, Jessica Barlinn, Johann Lambeck, Feryal Saad, Scott D. Berkowitz, Hardi Mundl, Stuart J. Connolly, Robert G. Hart, T.S. Field, G.J. Stotts, D.J. Gladstone, S.J. Phillips, A. Sharrief, C. Holmstedt, N. Vora, C. Wilson, B.M. Coull, A. de Havenon, L.A. Birnbaum, N. Patel, M.S. Hussain, D. Greer, S. Chen, S. Kittner, D. Mehta, T. Lowenkopf, R. Sawyer, V. Babikian, R. Zweifler, D.L. Tirschwell, C. Sila, C. Zhang, K-S. Hong, K. Oh, J.H. Heo, H-J. Bae, M.S. Park, J.S. Kim, C-S. Chung, B-C. Lee, G.P. Povedano, J.J. Martin, G.M. Bruera, L.V. Jure, J. Marti-Fabregas, I.C. Naranjo, J.M.R. Moreno, P.C. Portela, M. Gomis, J. Serena, H. Christensen, T. Christensen, S. Knecht, M. Endres, J. Berrouschot, F. Schlachetzki, S. Wunderlich, P. Kraft, P. Guyler, RC. Veltkamp, M. Burn, K. Rashed, M.J. Macleod, C. Canepa, J. Selvarajah, D. Hargroves, Y. Behnam, T.G. Robinson, L. Roveri, G. Lembo, D.S. Toni, V. Monzani, A. Cavallini, D. Popov, M. Friedrich, C. Minelli, C. Moro, R.J. Gagliardi, A. Bacellar, R. Mikulik, J. Eckstein, G. Panczel, N. Szegedi, M.J. O’Donnell

Publikováno v: Sharma, M, Smith, E E, Pearce, L A, Shoamanesh, A, Perera, K S, Coutts, S B, Damgaard, D, Ameriso, S F, Rha, J H, Modrau, B, Yoon, B W, Romano, M, Messé, S R, Barlinn, J, Lambeck, J, Saad, F, Berkowitz, S D, Mundl, H, Connolly, S J, Hart, R G & the NAVIGATE ESUS MIND MRI Substudy Investigators 2022, ' Frequency and Patterns of Brain Infarction in Patients with Embolic Stroke of Undetermined Source : NAVIGATE ESUS Trial ', Stroke, vol. 53, no. 1, pp. 45-52 . https://doi.org/10.1161/STROKEAHA.120.032976
Sharma, M, Smith, E E, Pearce, L A, Shoamanesh, A, Perera, K S, Coutts, S B, Damgaard, D, Ameriso, S F, Rha, J-H, Modrau, B, Yoon, B-W, Romano, M, Messé, S R, Barlinn, J, Lambeck, J, Saad, F, Berkowitz, S D, Mundl, H, Connolly, S J, Hart, R G & NAVIGATE ESUS MIND MRI Substudy Investigators 2022, ' Frequency and Patterns of Brain Infarction in Patients With Embolic Stroke of Undetermined Source : NAVIGATE ESUS Trial ', Stroke, vol. 53, no. 1, STROKEAHA120032976, pp. 45-52 . https://doi.org/10.1161/STROKEAHA.120.032976

Background and Purpose: The spectrum of brain infarction in patients with embolic stroke of undetermined source (ESUS) has not been well characterized. Our objective was to define the frequency and pattern of brain infarcts detected by magnetic reson

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6bc84752acdbc3185ff205e2670b687
https://doi.org/10.1161/strokeaha.120.032976

Rivaroxaban versus aspirin for prevention of covert brain infarcts in patients with embolic stroke of undetermined source:NAVIGATE ESUS MRI substudy

Autor: Josep Puig, Nikolay Shamalov, Kanjana S Perera, Feryal Saad, Dániel Bereczki, Jochen B. Fiebach, Hardi Mundl, Martin J O’Donnell, Danilo Toni, Sebastián F. Ameriso, Dorte Damgaard, Roland Veltkamp, Stefan T. Engelter, Lesly A. Pearce, Byung-Woo Yoon, Keith W. Muir, Robert Mikulik, Eric E. Smith, Scott D. Berkowitz, Scott E. Kasner, Rubens José Gagliardi, Ashkan Shoamanesh, Robert G. Hart, Mukul Sharma

Publikováno v: Sharma, M, Smith, E E, Pearce, L A, Perera, K S, Kasner, S E, Yoon, B W, Ameriso, S F, Puig, J, Damgaard, D, Fiebach, J B, Muir, K W, Veltkamp, R C, Toni, D S, Shamalov, N, Gagliardi, R J, Mikulik, R, Engelter, S T, Bereczki, D, O’Donnell, M J, Saad, F, Shoamanesh, A, Berkowitz, S D, Mundl, H, Hart, R G & On behalf of the NAVIGATE ESUS MRI Substudy Investigators 2022, ' Rivaroxaban versus aspirin for prevention of covert brain infarcts in patients with embolic stroke of undetermined source : NAVIGATE ESUS MRI substudy ', International Journal of Stroke, vol. 17, no. 7, pp. 799-805 . https://doi.org/10.1177/17474930211058012

Background Covert brain infarcts are associated with important neurological morbidity. Their incidence in patients with embolic stroke of undetermined source (ESUS) is unknown. Aims To assess the incidence of covert brain infarcts and cerebral microb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f55e65432bf70532f0f32f8ab28c82aa
https://pure.au.dk/portal/da/publications/rivaroxaban-versus-aspirin-for-prevention-of-covert-brain-infarcts-in-patients-with-embolic-stroke-of-undetermined-source(4eabcadd-5683-4af5-b418-fc60e9212ac1).html

Rivaroxaban for Prevention of Covert Brain Infarcts and Cognitive Decline

Autor: Dragos Vinereanu, Georg Ertl, Stefan Störk, Deepak L. Bhatt, Nana Pogosova, John Varigos, Aldo P. Maggioni, Yan Liang, Andrew Tonkin, Stuart J. Connolly, Lars Rydén, Amparo Casanova, Jacqueline Bosch, Alvaro Avezum, Kelley R. Branch, Leanne Dyal, Rafael Diaz, Kevin W Reeh, Robert G. Hart, Keith A.A. Fox, Katalin Keltai, Patricio Lopez-Jaramillo, Mukul Sharma, Martin O'Donnell, Matyas Keltai, Eva Lonn, Lisheng Liu, Jun Zhu, Jeffrey L. Probstfield, Gilles R. Dagenais, Leopoldo S. Piegas, Scott D. Berkowitz, Salim Yusuf, Eric E. Smith, John W. Eikelboom, Jae-Hyung Kim

Publikováno v: Stroke. 51:2901-2909

Background and Purpose: Covert brain infarcts are associated with cognitive decline. It is not known whether therapies that prevent symptomatic stroke prevent covert infarcts. COMPASS compared rivaroxaban with and without aspirin with aspirin for the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d82eba458c83c97644eaf1c34656e43
https://doi.org/10.1161/strokeaha.120.029762