Zobrazeno 1 - 10
of 207
pro vyhledávání: '"Robert G Gourdie"'
Autor:
Rengasayee Veeraraghavan, Gregory S Hoeker, Anita Alvarez-Laviada, Daniel Hoagland, Xiaoping Wan, D Ryan King, Jose Sanchez-Alonso, Chunling Chen, Jane Jourdan, Lori L Isom, Isabelle Deschenes, James W Smyth, Julia Gorelik, Steven Poelzing, Robert G Gourdie
Publikováno v:
eLife, Vol 7 (2018)
Computational modeling indicates that cardiac conduction may involve ephaptic coupling – intercellular communication involving electrochemical signaling across narrow extracellular clefts between cardiomyocytes. We hypothesized that β1(SCN1B) –m
Externí odkaz:
https://doaj.org/article/32935da885304be98d92667cd78158c7
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86570 (2014)
The alpha-carboxy terminus 1 (αCT1) peptide is a synthetically produced mimetic modified from the DDLEI C-terminus sequence of connexin 43 (Cx43). Previous research using various wound healing models have found promising therapeutic effects when app
Externí odkaz:
https://doaj.org/article/22c9e28a966b4f76a2beb365f82ed033
Publikováno v:
Diagnostics, Vol 14, Iss 20, p 2325 (2024)
Background/Objectives: The precise quantification of myocardial infarction is crucial for evaluating therapeutic strategies. We developed a robust, color-based semi-automatic algorithm capable of infarct region detection, isolation and quantification
Externí odkaz:
https://doaj.org/article/3aa498805e9d41b3acebb6223656bceb
Autor:
Allen C. T. Teng, Liyang Gu, Michelle Di Paola, Robert Lakin, Zachary J. Williams, Aaron Au, Wenliang Chen, Neal I. Callaghan, Farigol Hakem Zadeh, Yu-Qing Zhou, Meena Fatah, Diptendu Chatterjee, L. Jane Jourdan, Jack Liu, Craig A. Simmons, Thomas Kislinger, Christopher M. Yip, Peter H. Backx, Robert G. Gourdie, Robert M. Hamilton, Anthony O. Gramolini
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
The intercalated disc (ICD) is a membrane structure of the cardiac muscle involved in normal heart function. Here the authors report that knockdown of the ICD-bound transmembrane protein 65 results in impaired ICD structure, abnormal cardiac electrop
Externí odkaz:
https://doaj.org/article/aafde2c6ca28412ea8f19a14b47c1f34
Autor:
Kevin J. Pridham, Farah Shah, Kasen R. Hutchings, Kevin L. Sheng, Sujuan Guo, Min Liu, Pratik Kanabur, Samy Lamouille, Gabrielle Lewis, Marc Morales, Jane Jourdan, Christina L. Grek, Gautam G. Ghatnekar, Robin Varghese, Deborah F. Kelly, Robert G. Gourdie, Zhi Sheng
Publikováno v:
Oncogenesis, Vol 11, Iss 1, Pp 1-11 (2022)
Abstract Circumventing chemoresistance is crucial for effectively treating cancer including glioblastoma, a lethal brain cancer. The gap junction protein connexin 43 (Cx43) renders glioblastoma resistant to chemotherapy; however, targeting Cx43 is di
Externí odkaz:
https://doaj.org/article/f1ac0b6e646148b5b519e962c8c96c1b
Autor:
Jordan E. Morningstar, Cortney Gensemer, Reece Moore, Diana Fulmer, Tyler C. Beck, Christina Wang, Kelsey Moore, Lilong Guo, Franz Sieg, Yasufumi Nagata, Philippe Bertrand, Ricardo A. Spampinato, Janiece Glover, Stephen Poelzing, Robert G. Gourdie, Kelsey Watts, William J. Richardson, Robert A. Levine, Michael A. Borger, Russell A. Norris
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 24 (2021)
Background Mitral valve prolapse (MVP) is one of the most common forms of cardiac valve disease and affects 2% to 3% of the population. Previous imaging reports have indicated that myocardial fibrosis is common in MVP and described its association wi
Externí odkaz:
https://doaj.org/article/1bdbb2eee67f48e1b5967500ba35c49c
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 9, Iss 4, p 121 (2022)
The authors would like to make corrections to the reference citations in the original article [...]
Externí odkaz:
https://doaj.org/article/7c25249d2282487282a472c4ad17650b
Publikováno v:
Biomolecules, Vol 11, Iss 8, p 1192 (2021)
The Cx43 carboxyl-terminus (CT) mimetic peptide, αCT1, originally designed to bind to Zonula Occludens 1 (ZO1) and thereby inhibit Cx43/ZO1 interaction, was used as a tool to probe the role of Cx43/ZO1 association in regulation of epithelial/endothe
Externí odkaz:
https://doaj.org/article/573d746bb0bc40f094cc3ad7aeb9ff75
Autor:
William P. Adams, Tristan B. Raisch, Yajun Zhao, Rafael Davalos, Sarah Barrett, D. Ryan King, Chandra B. Bain, Katrina Colucci-Chang, Grace A. Blair, Alexandra Hanlon, Alicia Lozano, Rengasayee Veeraraghavan, Xiaoping Wan, Isabelle Deschenes, James W. Smyth, Gregory S. Hoeker, Robert G. Gourdie, Steven Poelzing
RationaleCardiac conduction is understood to occur through gap junctions. Recent evidence supports ephaptic coupling as another mechanism of electrical communication in heart. Conduction via gap junctions predicts a direct relationship between conduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eac8fb30b71eac4d9631495700813a9c
https://doi.org/10.1101/2023.05.25.542366
https://doi.org/10.1101/2023.05.25.542366
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 8, Iss 5, p 52 (2021)
Connexin (Cx43)-formed channels have been linked to cardiac arrhythmias and diseases of the heart associated with myocardial tissue loss and fibrosis. These pathologies include ischemic heart disease, ischemia-reperfusion injury, heart failure, hyper
Externí odkaz:
https://doaj.org/article/58939f80077043238d032c81458f7c45