Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Robert G Ferris"'
Autor:
Kathy Triantafilou, Christopher J K Ward, Magdalena Czubala, Robert G Ferris, Emma Koppe, Curt Haffner, Vincent Piguet, Vipulkumar K Patel, Heather Amrine-Madsen, Louise K Modis, Seth L Masters, Martha Triantafilou
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009417 (2021)
Macrophages are important drivers of pathogenesis and progression to AIDS in HIV infection. The virus in the later phases of the infection is often predominantly macrophage-tropic and this tropism contributes to a chronic inflammatory and immune acti
Externí odkaz:
https://doaj.org/article/537924792012487eb14fefc52c9d380b
Autor:
Martha Triantafilou, Seth L. Masters, Robert G. Ferris, Louise K. Modis, Magdalena Czubala, Kathy Triantafilou, Christopher J. K. Ward, Emma Koppe, Curt Dale Haffner, Vipulkumar Kantibhai Patel, Heather Amrine-Madsen, Vincent Piguet
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 4, p e1009417 (2021)
PLoS Pathogens, Vol 17, Iss 4, p e1009417 (2021)
Macrophages are important drivers of pathogenesis and progression to AIDS in HIV infection. The virus in the later phases of the infection is often predominantly macrophage-tropic and this tropism contributes to a chronic inflammatory and immune acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db110e44ba2fb7ba2b06a3325be12d86
https://pubmed.ncbi.nlm.nih.gov/33861800
https://pubmed.ncbi.nlm.nih.gov/33861800
Autor:
Steven E. Bosinger, Gavin C. Sampey, Zhang Wang, Jean-Pierre Routy, Robert G. Ferris, Rae Ann Spagnuolo, Edward P. Browne, Brandon F. Keele, Greg K. Tharp, Christopher C. Nixon, Nils Schoof, Christine M. Fennessey, Chandrav De, Corinne G. Cammon, Rachel A. Cleary, David Favre, Nancie M. Archin, J. Victor Garcia, Jennifer Deutsch, Angela Wahl, Sean Maguire, Hasse Walum, Thomas H. Vanderford, Cameron Mattingly, David M. Margolis, Baolin Liao, Nathaniel J. Schramm, Richard M. Dunham, Amit A. Upadhyay, Jessica H. Brehm, Cristin M. Galardi, Saintedym Wills, Corbin D. Jones, Maud Mavigner, Sherrie Jean, Jeffrey D. Lifson, Matt Kanke, Guido Silvestri, Phong T. Ho, Alyssa D. Brooks, Ann Chahroudi, David M. Irlbeck, Shane D. Falcinelli
Publikováno v:
Nature
Long-lasting, latently infected resting CD4+ T cells are the greatest obstacle to obtaining a cure for HIV infection, as these cells can persist despite decades of treatment with antiretroviral therapy (ART). Estimates indicate that more than 70 year
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12de8e37415a35a7eda62c90a149d687
https://doi.org/10.1038/s41577-020-0283-8
https://doi.org/10.1038/s41577-020-0283-8
Autor:
Robert G. Ferris
This book incorporates a comprehensive survey of sites and buildings associated with the signers of the Declaration of Independence. The book highlights the sites where freedom was forged and our founding fathers actually made the decisions which hav
Autor:
Eugene L. Stewart, Susan Danehower, Douglas J. Minick, Robert G. Ferris, Manon S. Villeneuve, Maosheng Duan, Wieslaw M. Kazmierski, Matthew J. Sharp, Vassil I. Elitzin
Publikováno v:
ACS Medicinal Chemistry Letters. 5:1296-1299
We recently reported the discovery of preclinical CCR5 inhibitor GSK214096, 1 (J. Med. Chem. 2011, 54, 756). Detailed characterization of 1 revealed that it exists as a mixture of four separable atropisomers A-D. The two slow-interconverting pairs of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a9d02f5e7ad5e1fc5de41536e22c152
https://doi.org/10.1021/ml5004124
https://doi.org/10.1021/ml5004124
Autor:
Andrew J. Peat, Kurt Weaver, Liping Wang, Sebahar Paul Richard, Eugene L. Stewart, Amanda Mathis, Robert T. Nolte, Dulce Garrido, Robert G. Ferris, Mark P. Edelstein, Huichang Zhang, Pek Yoke Chong, Michael Youngman
Publikováno v:
Journal of Medicinal Chemistry. 55:10601-10609
A new series of non-nucleoside reverse transcriptase inhibitors based on an imidazole-amide biarylether scaffold has been identified and shown to possess potent antiviral activity against HIV-1, including the NNRTI-resistant Y188L mutated virus. X-ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ddc8f9e72f78103aa7993201d354598
https://doi.org/10.1021/jm301294g
https://doi.org/10.1021/jm301294g
Autor:
Matthew David Tallant, Wieslaw M. Kazmierski, Pat Wheelan, Maosheng Duan, George Andrew Freeman, Mark P. Edelstein, Robert G. Ferris
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:1394-1398
We describe the synthesis and potency of a novel series of N-substituted 2-phenyl- and 2-methyl-2-phenyl-1,4-diaminobutane- based CCR5 antagonists. Compounds 7a and 12f were found to be potent in anti-HIV assays and bioavailable in the low-dose rat P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68dbee409884703c0fdfed425864b7bb
https://doi.org/10.1016/j.bmcl.2011.01.030
https://doi.org/10.1016/j.bmcl.2011.01.030
Autor:
George F. Dorsey, Maosheng Duan, Robert G. Ferris, Christopher Joseph Aquino, Wieslaw M. Kazmierski
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4988-4992
A series of 4,4-disubstituted cyclohexylamine based CCR5 antagonists has been designed and synthesized. Their antiviral structure-activity relationship has been extensively explored.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7acb6e82f6280aab3d57763a89557da2
https://doi.org/10.1016/j.bmcl.2009.07.074
https://doi.org/10.1016/j.bmcl.2009.07.074
Autor:
Terry P. Kenakin, Robert G. Ferris, Christopher Joseph Aquino, Pat Wheelan, Michael Youngman, Chris Watson, Cecilia S. Koble, Maosheng Duan, Wieslaw M. Kazmierski
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1610-1613
Several series of CCR5 antagonists have been discovered by derivatization at the N-terminal of the piperidine ring of the core template 2. Some derivatives exhibited potent inhibition against HIV-1infection. The pharmacokinetic properties of the lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b95251eb83cd30c70b43dd2a152648fc
https://doi.org/10.1016/j.bmcl.2009.02.014
https://doi.org/10.1016/j.bmcl.2009.02.014
Autor:
Edward P. Garvey, Brian A. Johns, Margaret J. Gartland, Scott A. Foster, Wayne H. Miller, Robert G. Ferris, Richard J. Hazen, Mark R. Underwood, Eric E. Boros, James B. Thompson, Jason G. Weatherhead, Cecilia S. Koble, Scott H. Allen, Lee T. Schaller, Ronald G. Sherrill, Tomokazu Yoshinaga, Masanori Kobayashi, Chiaki Wakasa-Morimoto, Shigeru Miki, Koichiro Nakahara, Takeshi Noshi, Akihiko Sato, Tamio Fujiwara
Publikováno v:
Antimicrobial Agents and Chemotherapy. 52:901-908
The naphthyridinone GSK364735 potently inhibited recombinant human immunodeficiency virus type 1 (HIV-1) integrase in a strand transfer assay (mean 50% inhibitory concentration ± standard deviation, 8 ± 2 nM). As expected based on the structure of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f1ce24916536e22a701ee05912ccf1b
https://doi.org/10.1128/aac.01218-07
https://doi.org/10.1128/aac.01218-07