Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Robert G, Roth"'
Autor:
Sophia Hober, Cecilia Hellström, Jennie Olofsson, Eni Andersson, Sofia Bergström, August Jernbom Falk, Shaghayegh Bayati, Sara Mravinacova, Ronald Sjöberg, Jamil Yousef, Lovisa Skoglund, Sara Kanje, Anna Berling, Anne‐Sophie Svensson, Gabriella Jensen, Henric Enstedt, Delaram Afshari, Lan Lan Xu, Martin Zwahlen, Kalle vonFeilitzen, Leo Hanke, Ben Murrell, Gerald McInerney, Gunilla B Karlsson Hedestam, Christofer Lendel, Robert G Roth, Ingmar Skoog, Elisabet Svenungsson, Tomas Olsson, Anna Fogdell‐Hahn, Ylva Lindroth, Maria Lundgren, Kimia T Maleki, Nina Lagerqvist, Jonas Klingström, Rui Da Silva Rodrigues, Sandra Muschiol, Gordana Bogdanovic, Laila Sara Arroyo Mühr, Carina Eklund, Camilla Lagheden, Joakim Dillner, Åsa Sivertsson, Sebastian Havervall, Charlotte Thålin, Hanna Tegel, Elisa Pin, Anna Månberg, My Hedhammar, Peter Nilsson
Publikováno v:
Clinical & Translational Immunology, Vol 10, Iss 7, Pp n/a-n/a (2021)
Abstract Objective The COVID‐19 pandemic poses an immense need for accurate, sensitive and high‐throughput clinical tests, and serological assays are needed for both overarching epidemiological studies and evaluating vaccines. Here, we present th
Externí odkaz:
https://doaj.org/article/8b5b60f5e8974c2ab35d2703899e52f2
Autor:
Andrea Martella, Robert G. Roth, Benjamin J. M. Taylor, Anne Göppert, Emanuela M. Cuomo, Alan J. Dickson, David I Fisher, Mike Firth
Publikováno v:
ACS Synthetic Biology. 8:1998-2006
The ability to manipulate the expression of mammalian genes using synthetic transcription factors is highly desirable in both fields of basic research and industry for diverse applications, including stem cell reprogramming and differentiation, tissu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d70189414c198351d1bb9b9c9172185
https://doi.org/10.1021/acssynbio.8b00527
https://doi.org/10.1021/acssynbio.8b00527
MALT1 auto-proteolysis is essential for NF-κB-dependent gene transcription in activated lymphocytes.
Autor:
Mathijs Baens, Luca Bonsignore, Riet Somers, Charlotte Vanderheydt, Stephen D Weeks, Jenny Gunnarsson, Ewa Nilsson, Robert G Roth, Margot Thome, Peter Marynen
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e103774 (2014)
Mucosa-associated lymphoid tissue 1 (MALT1) controls antigen receptor-mediated signalling to nuclear factor κB (NF-κB) through both its adaptor and protease function. Upon antigen stimulation, MALT1 forms a complex with BCL10 and CARMA1, which is e
Externí odkaz:
https://doaj.org/article/d497c7b166e14fea9cbd657798562bcf
Autor:
Tomas Akerud, Hannah de la Motte, Eva Hurt-Camejo, Tim D. J. Perkins, Åsa Månsson, Frank Jansen, Hans-Georg Beisel, Mikael Dahlström, Gabrielle Saarinen, Fabrizio Giordanetto, Robert G. Roth, Marie Ahlqvist, Fredrik Klingegård, Birgitta Rosengren, Laurent Knerr, Kenth Hallberg, Ingemar Starke, Jenny Sandmark, Daniel Pettersen, Nidhal Selmi, Margareta Herslöf, Johan Brengdahl, Tommy Olsson, Mattias Rohman, Peter Nordberg, Johan Broddefalk
Publikováno v:
ACS Medicinal Chemistry Letters. 9:594-599
[Image: see text] In order to assess the potential of sPLA(2)-X as a therapeutic target for atherosclerosis, novel sPLA(2) inhibitors with improved type X selectivity are required. To achieve the objective of identifying such compounds, we embarked o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3062a7d8619a16b010f0164ff18f98cf
https://doi.org/10.1021/acsmedchemlett.7b00505
https://doi.org/10.1021/acsmedchemlett.7b00505
Autor:
Tomas Akerud, Bingze Xu, Göran Dahl, Robert G. Roth, Patrik Johansson, Anna Aagaard, Maria Sörhede Winzell, Janna M. Bigalke, G. Jonah A. Rainey, Jenny Sandmark, Pia Davidsson, Linda Öster
Publikováno v:
Journal of Biological Chemistry. 293:5492-5508
Neurturin (NRTN) provides trophic support to neurons and is considered a therapeutic agent for neurodegenerative diseases, such as Parkinson's disease. It binds to its co-receptor GFRa2, and the resulting NRTN–GFRa2 complex activates the transmembr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f03dc7b12e7a3f6af84b761a8ee197bd
https://doi.org/10.1074/jbc.ra117.000820
https://doi.org/10.1074/jbc.ra117.000820
Publikováno v:
Biotechnology and Bioengineering. 114:2348-2359
Certain recombinant proteins are deemed "difficult to express" in mammalian expression systems requiring significant cell and/or process engineering to abrogate expression bottlenecks. With increasing demand for the production of recombinant proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cb9543d44bedcf106cb1e0a6fc49a28
https://doi.org/10.1002/bit.26358
https://doi.org/10.1002/bit.26358
Autor:
Varnika Roy, Mark Berge, Srilatha Kuntumalla, Robert G. Roth, Albert E. Schmelzer, Rajesh Chitta, Ron Schoner, Sucheta Vajrala
Publikováno v:
Biotechnology and Bioengineering. 114:1753-1761
Human neurturin (NTN) is a cystine knot growth factor with potential therapeutic use in diseases such as Parkinson's and diabetes. Scalable high titer production of native NTN is particularly challenging because of the cystine knot structure which co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a97dae58c3158fbc6d4bfb9a36b5f1aa
https://doi.org/10.1002/bit.26299
https://doi.org/10.1002/bit.26299
Autor:
Janna M. Bigalke, Göran Dahl, Shintaro Aibara, Alexey Amunts, Sarah Dorbéus, Jenny Sandmark, Robert G. Roth, Euan Gordon
Publikováno v:
Science Advances
We report the first subnanometer resolution structure of the RET extracellular domain in complex with a ligand and co-receptor.
Signaling through the receptor tyrosine kinase RET is essential during normal development. Both gain- and loss-of-fun
Signaling through the receptor tyrosine kinase RET is essential during normal development. Both gain- and loss-of-fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d15ca001d0891e5d7e169e51235f7ba
http://europepmc.org/articles/PMC6669014
http://europepmc.org/articles/PMC6669014
Autor:
Arun Sharma, Chester Bittencourt Sacramento, Guoling Xi, Thomas Linke, Robert G. Roth, Reza Esfandiary, Hani Jouihan
Publikováno v:
Protein Expression and Purification. 168:105552
Neurturin is a potent neurotrophic factor that has been investigated as a potential therapeutic agent for the treatment of neurodegenerative diseases, including Parkinson's disease, and, more recently, for the treatment of type II diabetes. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf81e15b8e9ec430a33857e0cbf1e75f
https://doi.org/10.1016/j.pep.2019.105552
https://doi.org/10.1016/j.pep.2019.105552
Autor:
Johannes Wikström, Johan Brengdahl, Hanna De La Motte, Hans Georg Beisel, Maria Wågberg, Robert G. Roth, Mikael Dahlström, Nidhal Selmi, Gabrielle Saarinen, Daniel Pettersen, Fabrizio Giordanetto, Eva Hurt-Camejo, Åsa Månsson, Frank Jansen, Mattias Rohman, Laurent Knerr, Fredrik Klingegård, Birgitta Rosengren, Marie Ahlqvist, Tomas Akerud, Jenny Sandmark, Johan Broddefalk, Peter Nordberg
[Image: see text] A lead generation campaign identified indole-based sPLA(2)-X inhibitors with a promising selectivity profile against other sPLA(2) isoforms. Further optimization of sPLA(2) selectivity and metabolic stability resulted in the design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5426bebf6e544cdf4fd5b3f245895890
https://europepmc.org/articles/PMC6047026/
https://europepmc.org/articles/PMC6047026/
