Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Robert G, Fox"'
Autor:
Christina R. Merritt, Erik J. Garcia, Victoria D. Brehm, Robert G. Fox, F. Gerard Moeller, Noelle C. Anastasio, Kathryn A. Cunningham
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
The drug overdose crisis has spawned serious health consequences, including the increased incidence of substance use disorders (SUDs), conditions manifested by escalating medical and psychological impairments. While medication management is a key adj
Externí odkaz:
https://doaj.org/article/bc5ee146b59c47cebdd20f0feff079c3
Autor:
Claudia A. Soto, Huang-Chi Du, Robert G. Fox, Taegyun Yang, James Hooson, Noelle C. Anastasio, Scott R. Gilbertson, Kathryn A. Cunningham
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Hypofunction of the serotonin (5-HT) 5-HT2C receptor (5-HT2CR) has been implicated in a variety of disorders including substance use disorders. As such, approaches to enhance 5-HT2CR signaling display therapeutic potential. In the present study, we s
Externí odkaz:
https://doaj.org/article/8c3c161a6ab2410781b8ed5bd4c5a571
Autor:
Sonja J. Stutz, Kathryn A. Cunningham, Irma E. Cisneros, Robert G. Fox, Natalya Bukreyeva, Kelly T. Dineley, Slobodan Paessler, Chiomah Ezeomah
Publikováno v:
Brain, Behavior, and Immunity. 87:725-738
Opioid use disorder (OUD) affects over two million in the United States and is an increasing public health crisis. The abuse of fentanyl and the emergence of potent fentanyl derivatives increases the risk for the user to succumb to overdose, but also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d6576481a9a00635839bcf26d189eeb
https://doi.org/10.1016/j.bbi.2020.03.003
https://doi.org/10.1016/j.bbi.2020.03.003
Autor:
Christopher Wild, Joanna Miszkiel, Robert G. Fox, Jianping Chen, Eric A. Wold, Kathryn A. Cunningham, Noelle C. Anastasio, Erik J. Garcia, Konrad Pazdrak, Claudia A. Soto, Jia Zhou
Publikováno v:
J Med Chem
Targeting the serotonin (5-HT) 5-HT(2C) receptor (5-HT(2C)R) allosteric site to potentiate endogenous 5-HT tone may provide novel therapeutics to alleviate the impact of costly, chronic diseases such as obesity and substance use disorders. Expanding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32dff7aa9f32c25f56aa49b2a127e75d
https://doi.org/10.1021/acs.jmedchem.9b01953
https://doi.org/10.1021/acs.jmedchem.9b01953
Autor:
Sanjana Manja, Caitlin R. Schlagal, Ping Wu, Pei Xu, Robert G. Fox, Christina R. Merritt, George R. Saade, Yongjia Yu, Tiffany J. Dunn, Shelly A. Buffington, Kathryn A. Cunningham, Daniel E. Felsing, Kelly T. Dineley
Publikováno v:
Neuroscience
Opioid use by women during pregnancy has risen dramatically since 2004, accompanied by a striking increase in the prevalence of neonatal opioid withdrawal syndrome (NOWS) and other long-term neurological deficits. However, the mechanisms underlying t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64201b5b6b9667da7ee84b9194f9e7e6
https://pubmed.ncbi.nlm.nih.gov/33811940
https://pubmed.ncbi.nlm.nih.gov/33811940
Autor:
David Andrew Nielsen, Wen eHuang, Sara C. Hamon, Lorena eMaili, Brian M. Witkin, Robert G. Fox, Kathryn A. Cunningham, F. Gerard Moeller
Publikováno v:
Frontiers in Psychiatry, Vol 3 (2012)
Background: Human cocaine abuse is associated with alterations in white matter integrity revealed upon brain imaging, an observation that is recapitulated in an animal model of continuous cocaine exposure. The mechanism through which cocaine may affe
Externí odkaz:
https://doaj.org/article/ffcaf14149fb43aebf0aa59a364523ee
Autor:
Noelle C. Anastasio, F. Gerard Moeller, Robert G. Fox, Kathryn A. Cunningham, Kenner C. Rice, Dennis J. Sholler, Qin Wang, Sonja J. Stutz, Edward L. Boone
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 368:41-49
Impulsivity and the attentional orienting response to cocaine-associated cues (cue reactivity) promote relapse in cocaine-use disorder (CUD). A time-dependent escalation of cue reactivity (incubation) occurs during extended, forced abstinence from co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade4c92d1286ec699b3c709f3b9effd2
https://doi.org/10.1124/jpet.118.251199
https://doi.org/10.1124/jpet.118.251199
Autor:
Cheryl S. Watson, Kathryn A. Cunningham, Scott R. Gilbertson, Matthew J. Shashack, Robert G. Fox, Kenner C. Rice, Marcy J. Bubar, Noelle C. Anastasio, Claudia A. Soto
Publikováno v:
ACS Chemical Neuroscience. 9:514-521
The 5-HT2AR plays an important role in various neuropsychiatric disorders including cocaine use disorder and schizophrenia. Homodimerization of this receptor has been suggested but tools that allow direct assessment of 5-HT2AR:5-HT2AR homodimer relev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24210dc819adeb5e5538f92bb6a62369
https://doi.org/10.1021/acschemneuro.7b00309
https://doi.org/10.1021/acschemneuro.7b00309
Autor:
Larry Denner, Robert G. Fox, Kathryn A. Cunningham, Scott D. Lane, Kelly T. Dineley, Sonja J. Stutz, William R Miller
Publikováno v:
Addiction Biology. 23:55-68
Cocaine use disorder is a chronic relapsing condition characterized by compulsive drug seeking and taking even after prolonged abstinence periods. Subsequent exposure to drug-associated cues can promote intense craving and lead to relapse in abstinen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80f079aa0810bc158e866343125826a3
https://doi.org/10.1111/adb.12471
https://doi.org/10.1111/adb.12471
Autor:
Robert G. Fox, James M. Bjork, Christina R. Merritt, Dennis J. Sholler, F. Gerard Moeller, Sonja J. Stutz, Kathryn A. Cunningham, Noelle C. Anastasio
Publikováno v:
Neuropharmacology
Cocaine use disorder (CUD) is a major public health challenge for which there are no pharmacotherapeutics approved by the United States Food and Drug Administration (FDA). The propensity to relapse in CUD involves several vulnerability factors includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58592a3782f57adae136fa26b2c56081
https://doi.org/10.1016/j.neuropharm.2020.108009
https://doi.org/10.1016/j.neuropharm.2020.108009