Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Robert G, Brinson"'
Autor:
Tsega L. Solomon, Frank Delaglio, John P. Giddens, John P. Marino, Yihua Bruce Yu, Marc B. Taraban, Robert G. Brinson
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTThe clinical efficacy and safety of protein-based drugs such as monoclonal antibodies (mAbs) rely on the integrity of the protein higher order structure (HOS) during product development, manufacturing, storage, and patient administration. As
Externí odkaz:
https://doaj.org/article/bb46764035b14affa365dc495b827f5d
Autor:
Katharina Yandrofski, Trina Mouchahoir, M. Lorna De Leoz, David Duewer, Jeffrey W. Hudgens, Kyle W. Anderson, Luke Arbogast, Frank Delaglio, Robert G. Brinson, John P. Marino, Karen Phinney, Michael Tarlov, John E. Schiel
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Biopharmaceuticals such as monoclonal antibodies are required to be rigorously characterized using a wide range of analytical methods. Various material properties must be characterized and well controlled to assure that clinically relevant features a
Externí odkaz:
https://doaj.org/article/67fbc3d00ac146b9a2150b1bb93b2842
Autor:
Tsega L. Solomon, Kinlin Chao, Genevieve Gingras, Yves Aubin, William B. O’Dell, John P. Marino, Robert G. Brinson
Publikováno v:
Biomolecular NMR Assignments. 17:75-81
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44beea3f4de7ed73011b98c4bd8ce06b
https://doi.org/10.1007/s12104-023-10123-9
https://doi.org/10.1007/s12104-023-10123-9
Autor:
Robert G. Brinson
Publikováno v:
Molecules, Vol 26, Iss 23, p 7091 (2021)
Nuclear magnetic resonance spectroscopy (NMR) is known to be a powerful technique for the characterization of small molecules and structural and dynamics studies of biomolecules [...]
Externí odkaz:
https://doaj.org/article/3b88d02a750a4044a1b6fef6eb91980d
Publikováno v:
Nucleic acid therapeutics. 32(4)
Nucleic acids are an increasingly popular platform for the development of biotherapeutics to treat a wide variety of illnesses, including diseases where traditional drug development efforts have failed. To date, there are 14 short oligonucleotide the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be180cacb73608ce0d55995f829bb1a8
https://pubmed.ncbi.nlm.nih.gov/35263184
https://pubmed.ncbi.nlm.nih.gov/35263184
Autor:
Joshua A Imperatore, Caylee L Cunningham, Kendy A Pellegrene, Robert G Brinson, John P Marino, Jeffrey D Evanseck, Mihaela Rita Mihailescu
Publikováno v:
Nucleic Acids Research
The ongoing COVID-19 pandemic highlights the necessity for a more fundamental understanding of the coronavirus life cycle. The causative agent of the disease, SARS-CoV-2, is being studied extensively from a structural standpoint in order to gain insi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06bd81b034dec1e63515faf89db5a7f3
http://europepmc.org/articles/PMC8789046
http://europepmc.org/articles/PMC8789046
Publikováno v:
Pharmaceutical Research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac311e9c838dade747cbdb8fb492fb3d
https://doi.org/10.1007/s11095-022-03403-x
https://doi.org/10.1007/s11095-022-03403-x
Autor:
D. Travis Gallagher, Chris McCullough, Robert G. Brinson, Joomi Ahn, John P. Marino, Nazzareno Dimasi
Publikováno v:
Pharmaceutics, Vol 11, Iss 10, p 546 (2019)
Antibody-drug conjugates (ADCs) are a class of biotherapeutic drugs designed as targeted therapies for the treatment of cancer. Among the challenges in generating an effective ADC is the choice of an effective conjugation site on the IgG. One common
Externí odkaz:
https://doaj.org/article/09fb0c4bd2d441f2b015033ae9f88c2c
Publikováno v:
International Journal of Mass Spectrometry. 481:116913
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ee7ed5d7e54bb0dd6f1a51be843af7e
https://doi.org/10.1016/j.ijms.2022.116913
https://doi.org/10.1016/j.ijms.2022.116913
Autor:
David A. Sheen, John P. Marino, Robert G. Brinson, Vincent K. Shen, Luke W. Arbogast, Frank Delaglio
Publikováno v:
Chemometr Intell Lab Syst
Protein therapeutics are vitally important clinically and commercially, with monoclonal antibody (mAb) therapeutic sales alone accounting for $115 billion in revenue for 2018.[1] In order for these therapeutics to be safe and efficacious, their prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::449c704db717ca259970616e97be71d9
https://pubmed.ncbi.nlm.nih.gov/34135539
https://pubmed.ncbi.nlm.nih.gov/34135539