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Pharmacokinetics and Antitumor Efficacy of XMT-1001, a Novel, Polymeric Topoisomerase I Inhibitor, in Mice Bearing HT-29 Human Colon Carcinoma Xenografts

Autor: Timothy B. Lowinger, Jeremy M. Sen, William C. Zamboni, Robert Fram, Suzan K. Hanna, Aleksandr V. Yurkovetskiy, Carolina B. Cabral, S. Rawal, Mark D. Walsh

Publikováno v: Clinical Cancer Research. 18:2591-2602

Purpose: To evaluate the pharmacokinetics and tissue disposition of macromolecular camptothecin (CPT) drug conjugate, XMT-1001, and irinotecan (CPT-11) in mice bearing HT-29 xenograft tumors. Experimental Design: The antitumor efficacy of XMT-1001 wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6478fb8744ed95cad98b99e50ea6e9f
https://doi.org/10.1158/1078-0432.ccr-11-1554

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A Perspective on Errors, Bias, and Interpretation in the Forensic Sciences and Direction for Continuing Advancement

Autor: Robert Fram, Melissa A. Smrz, Cary T. Oien, Bruce Budowle, Robert B. Stacey, Danielle P. Seiger, Stephen Meagher, Stephen G. Bunch, Michael B. Smith, Greg L. Soltis, Maureen C. Bottrell, Peter E. Peterson, Diana Harrison

Publikováno v: Journal of Forensic Sciences. 54:798-809

The forensic sciences are under review more so than ever before. Such review is necessary and healthy and should be a continuous process. It identifies areas for improvement in quality practices and services. The issues surrounding error, i.e., measu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90480db0871497ed3446fde5ab7e81b2
https://doi.org/10.1111/j.1556-4029.2009.01081.x

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Hypercalcemia and T-Cell Lymphoma With Acquired Immunodeficiency Syndrome

Autor: SHYAM KOTTILIL, ROBERT FRAM, KAROLL CORTEZ, STANLEY SCHWARTZ, SREE HARI KESAN

Publikováno v: Southern Medical Journal. 93:894-897

We describe the case of a patient with acquired immunodeficiency syndrome (AIDS) who had a CD4 cell count of 60/microL, bilateral hilar adenopathy, and hypercalcemia. Transbronchial biopsy showed T-cell anaplastic large cell lymphoma. Serology was ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::369d70ea10ccbcb8d76a5b9b4686723d
https://doi.org/10.1097/00007611-200009000-00011

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XMT-1001, a novel polymeric camptothecin pro-drug in clinical development for patients with advanced cancer

Autor: Alexander V. Yurkovetskiy, Robert Fram

Publikováno v: Advanced drug delivery reviews. 61(13)

An overview of XMT-1001 is provided in the context of other topoisomerase I inhibitors conjugated to polymers or encapsulated in liposomes. XMT-1001 is a novel polymeric pro-drug derivative of camptothecin (CPT) with a molecular weight of 70 kDa, in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::159a513c28c466c2e7cb95640f3bc6b2
https://pubmed.ncbi.nlm.nih.gov/19682517

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Antineoplastic effects of chemotherapeutic agents are potentiated by NM-3, an inhibitor of angiogenesis

Autor: Corinne L, Reimer, Naoki, Agata, Jennifer G, Tammam, Michael, Bamberg, William M, Dickerson, George D, Kamphaus, Susan L, Rook, Michael, Milhollen, Robert, Fram, Raghu, Kalluri, Donald, Kufe, Surender, Kharbanda

Publikováno v: Cancer research. 62(3)

Antiangiogenic therapy, although effective in shrinking tumors, has not yet been established as a standalone treatment for cancer. This therapeutic limitation can be overcome by combining angiogenesis inhibitors with chemotherapeutic agents. NM-3, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ed920f449a3db801da1d00772469508a
https://pubmed.ncbi.nlm.nih.gov/11830534

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Phase I and pharmacokinetic study of LU79553, a DNA intercalating bisnaphthalimide, in patients with solid malignancies

Autor: Donald Kufe, Lee F. Allen, Betty Razvillas, Robert Fram, Deborah Toppmeyer, Anthony A. Amato, Raja Velagapudi, Eric K. Rowinsky, Miguel A. Villalona-Calero, Daniel D. Von Hoff, Michael Myers, Kathleen Kagen-Hallet, Joseph Paul Eder

Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 19(3)

PURPOSE: To determine the maximum-tolerated dose and characterize the pharmacokinetic behavior of LU79553, a novel bisnaphthalimide antineoplastic agent, when administered as a daily intravenous infusion for 5 days every 3 weeks. PATIENTS AND METHODS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca10217cb5342608774eb17ab8dcc06
https://pubmed.ncbi.nlm.nih.gov/11157040

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A phase I clinical and pharmacokinetic study of the dolastatin analogue cemadotin administered as a 5-day continuous intravenous infusion

Autor: Jeffrey W. Clark, Jeffrey G. Supko, Donald Kufe, Lee F. Allen, Joseph Paul Eder, Thomas J. Lynch, Robert Fram, Raja Velagapudi

Publikováno v: Cancer chemotherapy and pharmacology. 46(4)

Purpose: The dolastatins are a class of naturally occurring cytotoxic peptides which function by inhibiting microtubule assembly and tubulin polymerization. Cemadotin is a synthetic analogue of dolastatin 15 with potent antiproliferative and preclini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b805811fc007f482e70bf1224c737d5b
https://pubmed.ncbi.nlm.nih.gov/11052630

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Phase I study of XMT-1001 given IV every 3 weeks to patients with advanced solid tumors

Autor: Robert Fram, Glen J. Weiss, C. Bethune, Ramesh K. Ramanathan, A. V. Yurkovetskiy, Edward A. Sausville, Dana Shkolny, Lawrence E. Garbo

Publikováno v: Journal of Clinical Oncology. 28:e13121-e13121

e13121 Background: XMT-1001 is a water soluble macromolecular conjugate of camptothecin (CPT). In this novel CPT prodrug, CPT is conjugated with a 70 kDa biodegradable hydrophilic polyacetal, poly ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::23bb758fc38cbb065a45da9d16268a1e
https://doi.org/10.1200/jco.2010.28.15_suppl.e13121

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