Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Robert Fitts"'
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Akademický článek
371 Decreased Contraction Rate, Altered Calcium Transients, and Increased Proliferation seen in Patient-specific iPSC-CMs Modeling Ebsteins Anomaly and Left Ventricular Noncompaction
Autor: Sai Suma Samudrala, Melissa Anfinson, Matthew Cavanaugh, Min-Su Kim, Peter Lamberton, Jackson Radandt, Ryan Brown, Huan Ling Liang, Karl Stamm, Afzal Zeeshan, Jennifer Strande, Michele Frommelt, John W. Lough, Robert Fitts, Michael E. Mitchell, Aoy Tomita-Mitchel
Publikováno v: Journal of Clinical and Translational Science, Vol 6, Pp 69-70 (2022)
OBJECTIVES/GOALS: In a familial case where 10 of 17 members inherited EA/LVNC in an autosomal dominant pattern, we discovered a novel, damaging missense variant in the gene KLHL26 that segregates with disease and comprises an altered electrostatic su
Externí odkaz: https://doaj.org/article/364e54d0a6cd481b8c9815acdfaff245
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2
The novel MYH6-E1584K tail domain variant associated with hypoplastic left heart syndrome leads to hypercontractility in vitro
Autor: Melissa Anfinson, Suma Thareja, Matthew Cavanaugh, Ryan Brown, Min-Su Kim, Huan-Ling Liang, Michael Mitchell, Robert Fitts, Aoy Tomita-Mitchell
Publikováno v: Physiology. 38
Hypoplastic left heart syndrome (HLHS) is a complex form of congenital heart disease (CHD) characterized by hypoplasia of the left ventricle and proximal aorta, as well as stenosis or atresia of the mitral and aortic valves. Our lab previously identi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::714030560b9e429d9bbb8625ae7ae5b7
https://doi.org/10.1152/physiol.2023.38.s1.5733555
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3
Effects of elevated H+ and Pi on the force-pCa relationship of skeletal muscle fibers from young and older adults
Autor: Carlos Zepeda, Laura Teigen, Robert Fitts, Sandra Hunter, Christopher Sundberg
Publikováno v: Physiology. 38
Introduction: The cellular mechanisms for the increased fatigability of older adults during dynamic contractions are not well understood. We recently observed that the depressive effects of fatiguing levels of acidosis (H+: pH 6.2) and inorganic phos
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61b6fa8f1492224114b1b31b24707bbb
https://doi.org/10.1152/physiol.2023.38.s1.5733603
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8
Effect of spaceflight on the maximal shortening velocity, morphology, and enzyme profile of fast- and slow-twitch skeletal muscle fibers in rhesus monkeys
Autor: Robert Fitts, Jg, Romatowski, De La Cruz L, Jj, Widrick, Desplanches D
Publikováno v: Europe PubMed Central
Weightlessness has been shown to cause limb muscle wasting and a reduced peak force and power in the antigravity soleus muscle. Despite a reduced peak power, Caiozzo et al. observed an increased maximal shortening velocity in the rat soleus muscle fo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::28714311e924b77471a634a64f54a321
http://europepmc.org/abstract/med/11543454
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9
Effect of spaceflight on the isotonic contractile properties of single skeletal muscle fibers in the rhesus monkey
Autor: Robert Fitts, Jg, Romatowski, Blaser C, De La Cruz L, Gj, Gettelman, Jj, Widrick
Publikováno v: Europe PubMed Central
Experiments from both Cosmos and Space Shuttle missions have shown weightlessness to result in a rapid decline in the mass and force of rat hindlimb extensor muscles. Additionally, despite an increased maximal shortening velocity, peak power was redu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b1a08d026e5ffd437f45a0d90375eaf2
http://europepmc.org/abstract/med/11543460
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