Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Robert F. Paulson"'
Autor:
Fenghua Qian, Shaneice K. Nettleford, Jiayan Zhou, Brooke E. Arner, Molly A. Hall, Arati Sharma, Charyguly Annageldiyev, Randy M. Rossi, Diwakar B. Tukaramrao, Deborpita Sarkar, Shailaja Hegde, Ujjawal H. Gandhi, Emily R. Finch, Laura Goodfield, Michael D. Quickel, David F. Claxton, Robert F. Paulson, K. Sandeep Prabhu
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112794- (2023)
Summary: Relapse of acute myeloid leukemia (AML) remains a significant concern due to persistent leukemia-initiating stem cells (LICs) that are typically not targeted by most existing therapies. Using a murine AML model, human AML cell lines, and pat
Externí odkaz:
https://doaj.org/article/ce35a814bf814b97aa20a01a202f9e01
Autor:
Baiye Ruan, Robert F. Paulson
Publikováno v:
Frontiers in Physiology, Vol 13 (2023)
Steady state erythropoiesis produces new erythrocytes at a constant rate to replace the senescent cells that are removed by macrophages in the liver and spleen. However, infection and tissue damage disrupt the production of erythrocytes by steady sta
Externí odkaz:
https://doaj.org/article/fbeaf2a05da144b5aab9d427285b6751
Autor:
Yaxian Kong, Bei Jia, Chenchen Zhao, David F. Claxton, Arati Sharma, Charyguly Annageldiyev, Joseph S. Fotos, Hui Zeng, Robert F. Paulson, K. Sandeep Prabhu, Hong Zheng
Publikováno v:
Journal of Hematology & Oncology, Vol 12, Iss 1, Pp 1-11 (2019)
Abstract Background Successful treatment for acute myeloid leukemia (AML) remains challenging. Inhibiting immune checkpoint to enhance anti-tumor response is an attractive strategy for effective leukemia therapeutics. CD73 is a recently recognized im
Externí odkaz:
https://doaj.org/article/0af86c29d57640ac8a9139d616b7bb2e
Publikováno v:
Cells, Vol 9, Iss 3, p 634 (2020)
Bone marrow medullary erythropoiesis is primarily homeostatic. It produces new erythrocytes at a constant rate, which is balanced by the turnover of senescent erythrocytes by macrophages in the spleen. Despite the enormous capacity of the bone marrow
Externí odkaz:
https://doaj.org/article/b8e0230645cd48d0bf219a19dfbe70d7
Autor:
Adwitia Dey, Joselyn N. Allen, James W. Fraser, Lindsay M. Snyder, Yuan Tian, Limin Zhang, Robert F. Paulson, Andrew Patterson, Margherita T. Cantorna, Pamela A. Hankey-Giblin
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Neurodegeneration is a critical problem in aging populations and is characterized by severe central nervous system (CNS) inflammation. Macrophages closely regulate inflammation in the CNS and periphery by taking on different activation states. The so
Externí odkaz:
https://doaj.org/article/ef4e1224294c4953ab00e676ad87afbf
Autor:
K. Sandeep Prabhu, Robert F. Paulson, Jay Whelan, Mary J. Kennett, Laura L. Goodfield, Michael D. Quickel, Avinash K. Kudva, Emily R. Finch
Current therapies for treatment of myeloid leukemia do not eliminate leukemia stem cells (LSC), leading to disease relapse. In this study, we supplemented mice with eicosapentaenoic acid (EPA, C20:5), a polyunsaturated omega-3 fatty acid, at pharmaco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d782de0ae58dca19d72c7b489efe09
https://doi.org/10.1158/1940-6207.c.6544929
https://doi.org/10.1158/1940-6207.c.6544929
Autor:
K. Sandeep Prabhu, Robert F. Paulson, Jay Whelan, Mary J. Kennett, Laura L. Goodfield, Michael D. Quickel, Avinash K. Kudva, Emily R. Finch
Supplemental Figure 1: Blood parameters in healthy mice are not affected by diet. Supplemental Figure 2: EPA decreases CML in EPA supplemented mice. Supplemental Figure 3: The antileukemic effect of EPA supplementation is dependent on functional prod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436c1f198a46f0446d79ac359f643b3a
https://doi.org/10.1158/1940-6207.22525833.v1
https://doi.org/10.1158/1940-6207.22525833.v1
Autor:
K. Sandeep Prabhu, Robert F. Paulson, Craig T. Jordan, Mary J. Kennett, Avinash K. Kudva, Emily R. Finch, Shailaja Hegde, Naveen Kaushal, Ujjawal H. Gandhi
PDF file - 772KB, Supplementary Figure 1. Selenium supplementation abrogates leukemia in a Friend leukemia (FVP) model. Supplementary Figure 2. Effect of selenium supplementation on the splenic histopathology in FVP-infected mice. Supplementary Figur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::309987a607a3b378168c79648b61279e
https://doi.org/10.1158/0008-5472.22404105
https://doi.org/10.1158/0008-5472.22404105
Autor:
Baiye Ruan, Yuanting Chen, Sara Trimidal, Imhoi Koo, Jingwei Cai, John Mcguigan, Molly A. Hall, Andrew D. Patterson, K. Sandeep Prabhu, Robert F. Paulson
Steady state erythropoiesis produces new erythrocytes at a constant rate to replace senescent erythrocytes removed in the spleen and liver. Inflammation caused by infection or tissue damage skews bone marrow hematopoiesis, increasing myelopoiesis at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6836a8a8162469e98f92b418f06d0915
https://doi.org/10.1101/2023.03.11.532211
https://doi.org/10.1101/2023.03.11.532211
Autor:
Baiye Ruan, Yuanting Chen, Sara Trimidal, Imhoi Koo, Fenghua Qian, Jingwei Cai, John Mcguigan, Molly A. Hall, Andrew D. Patterson, K. Sandeep Prabhu, Robert F. Paulson
Publikováno v:
bioRxiv
Inflammation skews bone marrow hematopoiesis increasing the production of myeloid effector cells at the expense of steady-state erythropoiesis. A compensatory stress erythropoiesis response is induced to maintain homeostasis until inflammation is res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5e3d71bb077934a1b0bb83caccbc345
https://europepmc.org/articles/PMC10028999/
https://europepmc.org/articles/PMC10028999/