Zobrazeno 1 - 10
of 287
pro vyhledávání: '"Robert F. Mullins"'
Autor:
Laura R. Bohrer, Nicholas E. Stone, Nathaniel K. Mullin, Andrew P. Voigt, Kristin R. Anfinson, Jessica L. Fick, Viviane Luangphakdy, Bradley Hittle, Kimerly Powell, George F. Muschler, Robert F. Mullins, Edwin M. Stone, Budd A. Tucker
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-14 (2023)
Abstract Background Inherited retinal degeneration is a leading cause of incurable vision loss in the developed world. While autologous iPSC mediated photoreceptor cell replacement is theoretically possible, the lack of commercially available technol
Externí odkaz:
https://doaj.org/article/183d75ad9ac2494ba237e6b2fd969f64
Autor:
Elaine M. Binkley, Lola P. Lozano, Megan J. Riker, Edward C. Pennington, Budd A. Tucker, Edwin M. Stone, H. Culver Boldt, Robert F. Mullins
Publikováno v:
Case Reports in Ophthalmology, Vol 13, Iss 2, Pp 589-598 (2022)
The effects of radiation retinopathy on the retinal vasculature have been well established; however, the literature describing the pathologic changes in the choriocapillaris is relatively lacking. In this report, we describe the histologic findings o
Externí odkaz:
https://doaj.org/article/99d5876cea0447d7b7236112e2e2c0db
Autor:
Nathaniel K. Mullin, Andrew P. Voigt, Miles J. Flamme-Wiese, Xiuying Liu, Megan J. Riker, Katayoun Varzavand, Edwin M. Stone, Budd A. Tucker, Robert F. Mullins
Publikováno v:
JCI Insight, Vol 8, Iss 14 (2023)
Variants within the high copy number mitochondrial genome (mtDNA) can disrupt organelle function and lead to severe multisystem disease. The wide range of manifestations observed in patients with mitochondrial disease results from varying fractions o
Externí odkaz:
https://doaj.org/article/286f23123b8c4dfab873c5c4a963e2d5
Publikováno v:
Stem Cells Translational Medicine, Vol 10, Iss 10, Pp 1384-1393 (2021)
Abstract Autologous photoreceptor cell replacement is one of the most promising approaches currently under development for the treatment of inherited retinal degenerative blindness. Unlike endogenous stem cell populations, induced pluripotent stem ce
Externí odkaz:
https://doaj.org/article/b4e11bb6335b409089d60070986885ae
Autor:
Carly van der Heide, Wes Goar, Kacie J. Meyer, Wallace L. M. Alward, Erin A. Boese, Nathan C. Sears, Ben R. Roos, Young H. Kwon, Adam P. DeLuca, Owen M. Siggs, Claudia Gonzaga-Jauregui, Val C. Sheffield, Kai Wang, Edwin M. Stone, Robert F. Mullins, Michael G. Anderson, Bao Jian Fan, Robert Ritch, Jamie E. Craig, Janey L. Wiggs, Todd E. Scheetz, John H. Fingert
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-12 (2021)
Abstract Background Glaucoma is a leading cause of visual disability and blindness. Release of iris pigment within the eye, pigment dispersion syndrome (PDS), can lead to one type of glaucoma known as pigmentary glaucoma. PDS has a genetic component,
Externí odkaz:
https://doaj.org/article/ce7f241b20c8405bb3d1d6a9635ffb16
Autor:
Jacob K. Sterling, Bailey Baumann, Sierra Foshe, Andrew Voigt, Samyuktha Guttha, Ahab Alnemri, Sam J. McCright, Mingyao Li, Randy J. Zauhar, Sandra R. Montezuma, Rebecca J. Kapphahn, Venkata R.M. Chavali, David A. Hill, Deborah A. Ferrington, Dwight Stambolian, Robert F. Mullins, David Merrick, Joshua L. Dunaief
Publikováno v:
Cell Reports, Vol 39, Iss 11, Pp 110942- (2022)
Summary: Age-related macular degeneration (AMD), the leading cause of irreversible blindness among Americans over 50, is characterized by dysfunction and death of retinal pigment epithelial (RPE) cells. The RPE accumulates iron in AMD, and iron overl
Externí odkaz:
https://doaj.org/article/a701cd56ed6f48bc9d2e45ba3c34f5f4
Autor:
Ian C. Han, Laura R. Bohrer, Katherine N. Gibson-Corley, Luke A. Wiley, Arwin Shrestha, Brynnon E. Harman, Chunhua Jiao, Elliott H. Sohn, Rion Wendland, Brittany N. Allen, Kristan S. Worthington, Robert F. Mullins, Edwin M. Stone, Budd A. Tucker
Publikováno v:
Cell Transplantation, Vol 31 (2022)
Loss of photoreceptor cells is a primary feature of inherited retinal degenerative disorders including age-related macular degeneration and retinitis pigmentosa. To restore vision in affected patients, photoreceptor cell replacement will be required.
Externí odkaz:
https://doaj.org/article/8593038b4cab42488737abbcbbab0ab6
Autor:
Kelly Mulfaul, Joseph C. Giacalone, Andrew P. Voigt, Megan J. Riker, Dalyz Ochoa, Ian C. Han, Edwin M. Stone, Robert F. Mullins, Budd A. Tucker
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-10 (2020)
Abstract Background Endothelial cells (ECs) are essential regulators of the vasculature, lining arteries, veins, and capillary beds. While all ECs share a number of structural and molecular features, heterogeneity exists depending on their resident t
Externí odkaz:
https://doaj.org/article/ab5227255d2347389d44837c07da74e1
Autor:
Guillermo L. Lehmann, Michael Ginsberg, Daniel J. Nolan, Cristina Rodríguez, José Martínez-González, Shemin Zeng, Andrew P. Voigt, Robert F. Mullins, Shahin Rafii, Enrique Rodriguez-Boulan, Ignacio Benedicto
Publikováno v:
Cells, Vol 11, Iss 19, p 2975 (2022)
Alpha-2-macroglobulin (A2M) is a protease inhibitor that regulates extracellular matrix (ECM) stability and turnover. Here, we show that A2M is expressed by endothelial cells (ECs) from human eye choroid. We demonstrate that retinal pigment epitheliu
Externí odkaz:
https://doaj.org/article/eda73ce701ce4b7fb8574dc854015da5
Autor:
Brittni A. Scruggs, Chunhua Jiao, Cathryn M. Cranston, Emily Kaalberg, Kai Wang, Stephen R. Russell, Luke A. Wiley, Robert F. Mullins, Edwin M. Stone, Budd A. Tucker, Elliott H. Sohn
Publikováno v:
Stem Cells Translational Medicine, Vol 8, Iss 8, Pp 797-809 (2019)
Abstract Subretinal delivery of stem cell‐derived retinal cells as a strategy to treat retinal degenerative blindness holds great promise. Currently, two clinical trials are underway in which human fetal retinal progenitor cells (RPCs) are being de
Externí odkaz:
https://doaj.org/article/e4373ca70dba4441939cd5b202824196