Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Robert F. Levendosky"'
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Chromatin remodelling enzymes (remodellers) regulate DNA accessibility of eukaryotic genomes, which rely in large part on an ability to reposition nucleosomes. Here the authors use three-colour single-molecule FRET to simultaneously monitor remodelle
Externí odkaz:
https://doaj.org/article/f5f376ca46c6431b91508a7dcbf9f536
Autor:
Robert F Levendosky, Gregory D Bowman
Publikováno v:
eLife, Vol 8 (2019)
The acidic patch is a functionally important epitope on each face of the nucleosome that affects chromatin remodeling. Although related by 2-fold symmetry of the nucleosome, each acidic patch is uniquely positioned relative to a bound remodeler. An o
Externí odkaz:
https://doaj.org/article/e0f87b0b34b24cc08a5977ca30551d04
Publikováno v:
eLife, Vol 7 (2018)
As superfamily 2 (SF2)-type translocases, chromatin remodelers are expected to use an inchworm-type mechanism to walk along DNA. Yet how they move DNA around the histone core has not been clear. Here we show that a remodeler ATPase motor can shift la
Externí odkaz:
https://doaj.org/article/e62dbc72c8e848209891939fe83cb5f7
Publikováno v:
eLife, Vol 5 (2016)
Despite their canonical two-fold symmetry, nucleosomes in biological contexts are often asymmetric: functionalized with post-translational modifications (PTMs), substituted with histone variants, and even lacking H2A/H2B dimers. Here we show that the
Externí odkaz:
https://doaj.org/article/53440152a4f045388019b63ce17736a7
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications
ATP-dependent chromatin remodelling enzymes (remodellers) regulate DNA accessibility in eukaryotic genomes. Many remodellers reposition (slide) nucleosomes, however, how DNA is propagated around the histone octamer during this process is unclear. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1120963a9cfd79c8bf39ee0d3dd43234
https://doaj.org/article/f5f376ca46c6431b91508a7dcbf9f536
https://doaj.org/article/f5f376ca46c6431b91508a7dcbf9f536
Publikováno v:
Proc Natl Acad Sci U S A
Chromatin remodelers are ATP (adenosine triphosphate)-powered motors that reposition nucleosomes throughout eukaryotic chromosomes. Remodelers possess autoinhibitory elements that control the direction of nucleosome sliding, but underlying mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e92ad1c2032dcd85febf528eaed3380
https://doi.org/10.1073/pnas.2014498118
https://doi.org/10.1073/pnas.2014498118
Publikováno v:
Curr Protoc Mol Biol
Nucleosomes are substrates for a broad range of factors, including those involved in transcription or chromosome maintenance/reorganization and enzymes that covalently modify histones. Given the heterogeneous nature of nucleosomes in vivo (i.e., vary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3130e653677903e20b3fd0ce19bb8f9
https://doi.org/10.1002/cpmb.130
https://doi.org/10.1002/cpmb.130
Autor:
Ming Yan, Rebecca J Tay, Gregory D. Bowman, Robert F Levendosky, Joshua M. Tokuda, Ren Ren, Lois Pollack
Publikováno v:
Nucleic Acids Research
Chromatin remodelers are ATP-dependent motors that reorganize DNA packaging by disrupting canonical histone–DNA contacts within the nucleosome. Here, we show that the Chd1 chromatin remodeler stimulates DNA unwrapping from the edge of the nucleosom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b893f30e2f123ac0ff5635b3eefaf177
https://doi.org/10.1093/nar/gky206
https://doi.org/10.1093/nar/gky206
Autor:
Gregory D. Bowman, Elijah Roberts, Jessica Winger, Michelle D. Wang, Ilana M. Nodelman, Ren Ren, Ashok Kumar Patel, Robert F Levendosky, Ming Li, Kyle Horvath
Publikováno v:
Nucleic Acids Research
Chromatin remodelers are essential for establishing and maintaining the placement of nucleosomes along genomic DNA. Yet how chromatin remodelers recognize and respond to distinct chromatin environments surrounding nucleosomes is poorly understood. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::799f8e1af43746b6f4f900fe8d1c9e30
http://europepmc.org/articles/PMC5027475
http://europepmc.org/articles/PMC5027475