Výsledky vyhledávání - "Robert F. Klees"

Revisiting Oversight and Regulation of Molecular-Based Laboratory-Developed Tests

Autor: Victoria M. Pratt, Jennifer R. Leib, Jan A. Nowak, Robert F. Klees, Roger D. Klein, Mary S. Williams, Stephen P. Day, Rajyasree Emmadi, Elaine Lyon, Andrea Ferreira-Gonzalez

Publikováno v: The Journal of Molecular Diagnostics. 16(1):3-6

Since 2006, the US Food and Drug Administration, Congress, and other policymakers have explored the appropriate way to guarantee the clinical and analytical validity of laboratory-developed tests. In the past, the Association for Molecular Pathology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::372fc99c8becde03aabe1d959da5680c

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Dissection of the osteogenic effects of laminin-332 utilizing specific LG domains: LG3 induces osteogenic differentiation, but not mineralization

Autor: Donna E. Crone, Robert F. Klees, Donald F. Ward, Mark P. Harris, William A. Williams, Vito Quaranta, Adele L. Boskey, George E. Plopper, Roman M. Salasznyk

Publikováno v: Experimental Cell Research. 314:763-773

The overall mechanisms governing the role of laminins during osteogenic differentiation of human mesenchymal stem cells (hMSC) are poorly understood. We previously reported that laminin-332 induces an osteogenic phenotype in hMSC and does so through

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6a7f507af23a484344e83ea68188d37
https://doi.org/10.1016/j.yexcr.2007.12.007

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Apocynin Derivatives Interrupt Intracellular Signaling Resulting in Decreased Migration in Breast Cancer Cells

Autor: Paul C. De Marco, Roman M. Salasznyk, Sylvain Antoniotti, Lakshmi Kamath, Jonathan S. Dordick, Disha Ahuja, George E. Plopper, Robert F. Klees, Michael G. Hogg

Publikováno v: Journal of Biomedicine and Biotechnology, Vol 2006 (2006)
Journal of Biomedicine and Biotechnology

Cancer cells are defined by their ability to divide uncontrollably and metastasize to secondary sites in the body. Consequently, tumor cell migration represents a promising target for anticancer drug development. Using our high-throughput cell migrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e98e02d67dd95fda8a5f87dbce4e7f
https://doi.org/10.1155/jbb/2006/87246

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Focusing of Gene Expression as the Basis of Stem Cell Differentiation

Autor: Aaron M. Westcott, George E. Plopper, Kristin P. Bennett, Robert F. Klees, Roman M. Salasznyk, Scott Vandenberg

Publikováno v: Stem Cells and Development. 14:608-620

In a prior report (Stem Cells Dev 14(4):354-366, 2005), we employed two-dimensional gel electrophoresis followed by advanced proteomics and the Database for Annotation, Visualization and Integrated Discovery (DAVID) to compare the protein expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1af0cb22a7f090ebf87e7a5cfa17deba
https://doi.org/10.1089/scd.2005.14.608

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Comparing the Protein Expression Profiles of Human Mesenchymal Stem Cells and Human Osteoblasts Using Gene Ontologies

Autor: Zhi Xiang, Donald F. Ward, Robert F. Klees, Scott R. VandenBerg, Roman M. Salasznyk, Kristin P. Bennett, Aaron M. Westcott, George E. Plopper

Publikováno v: Stem Cells and Development. 14:354-366

One of the hallmark events regulating the process of osteogenesis is the transition of undifferentiated human mesenchymal stem cells (hMSCs) found in the bone marrow into mineralized-matrix producing osteoblasts (hOSTs) through mechanisms that are no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49abc47cf6c90879055eca8061f63954
https://doi.org/10.1089/scd.2005.14.354

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ERK Signaling Pathways Regulate the Osteogenic Differentiation of Human Mesenchymal Stem Cells on Collagen I and Vitronectin

Autor: Robert F. Klees, George E. Plopper, Mariah K Hughlock, Roman M. Salasznyk

Publikováno v: Cell Communication & Adhesion. 11:137-153

Adhesion to the extracellular matrix (ECM) proteins collagen I and vitronectin is sufficient to drive human mesenchymal stem cells (hMSCs) into an osteogenic differentiation pathway, but the mechanisms underlying this stimulation are not well underst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c80f501b0331793ad61fcda2d7736b8
https://doi.org/10.1080/15419060500242836

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Revisiting oversight and regulation of molecular-based laboratory-developed tests: a position statement of the Association for Molecular Pathology

Autor: Andrea, Ferreira-Gonzalez, Rajyasree, Emmadi, Stephen P, Day, Robert F, Klees, Jennifer R, Leib, Elaine, Lyon, Jan A, Nowak, Victoria M, Pratt, Mary S, Williams, Roger D, Klein

Publikováno v: The Journal of molecular diagnostics : JMD. 16(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::98a034a1ed0cc76855216d3e67a5ee6f
https://pubmed.ncbi.nlm.nih.gov/24331365

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Focal adhesion kinase signaling controls cyclic tensile strain enhanced collagen I-induced osteogenic differentiation of human mesenchymal stem cells

Autor: Donald F, Ward, William A, Williams, Nicole E, Schapiro, Genevieve L, Weber, Samuel R, Christy, Megan, Salt, Robert F, Klees, Adele, Boskey, George E, Plopper

Publikováno v: Molecularcellular biomechanics : MCB. 4(4)

Focal adhesion kinase (FAK) is a key integrator of integrin-mediated signals from the extracellular matrix to the cytoskeleton and downstream signaling molecules. FAK is activated by phosphorylation at specific tyrosine residues, which then stimulate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e9f757187c6ef175a1f569ae6d12e76b
https://pubmed.ncbi.nlm.nih.gov/18437915

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Mechanical strain enhances extracellular matrix-induced gene focusing and promotes osteogenic differentiation of human mesenchymal stem cells through an extracellular-related kinase-dependent pathway

Autor: Donald F. Ward, Julianne Backiel, Phaedra Agius, Kristin P. Bennett, Robert F. Klees, Roman M. Salasznyk, Adele L. Boskey, George E. Plopper

Publikováno v: Stem cells and development. 16(3)

Human mesenchymal stem cells (hMSCs) are a population of multipotent bone marrow cells capable of differentiating along multiple lineages, including bone. Our recently published proteomics studies suggest that focusing of gene expression is the basis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efcf70d0434262910ae0402f78dab13b
https://pubmed.ncbi.nlm.nih.gov/17610377

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Activation of FAK is necessary for the osteogenic differentiation of human mesenchymal stem cells on laminin-5

Autor: George E. Plopper, Robert F. Klees, Adele L. Boskey, Roman M. Salasznyk

Publikováno v: Journal of cellular biochemistry. 100(2)

Human mesenchymal stem cell (hMSC) differentiation into osteoblasts and the signaling events involved are poorly understood. We recently established that contact with specific extracellular matrix (ECM) proteins, in particular laminin-5, is sufficien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::857fdc0917cd2454189894592bc39776
https://pubmed.ncbi.nlm.nih.gov/16927379

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