Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Robert F. Halliwell"'
Autor:
Hamed Salmanzadeh, Robert F. Halliwell
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Repeated and uncontrolled seizures in epilepsy result in brain cell loss and neural inflammation. Current anticonvulsants primarily target ion channels and receptors implicated in seizure activity. Identification of neurotherapeutics that can inhibit
Externí odkaz:
https://doaj.org/article/03f22a4d60be45f59805b9ec244633f0
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Modeling the complex and prolonged development of the mammalian central nervous system in vitro remains a profound challenge. Most studies of human stem cell derived neurons are conducted over days to weeks and may or may not include glia. Here we ha
Externí odkaz:
https://doaj.org/article/640a6975a1144a53adb44f92a3bb9728
Publikováno v:
Cells, Vol 10, Iss 8, p 1953 (2021)
Human stem cell-derived neurons are increasingly considered powerful models in drug discovery and disease modeling, despite limited characterization of their molecular properties. Here, we have conducted a detailed study of the properties of a commer
Externí odkaz:
https://doaj.org/article/c8c9b9fac91b42d9a329ab0445d77d11
Mechanisms Underlying Neuroprotection by the NSAID Mefenamic Acid in an Experimental Model of Stroke
Autor:
Parto S. Khansari, Robert F. Halliwell
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Stroke is a devastating neurological event with limited treatment opportunities. Recent advances in understanding the underlying pathogenesis of cerebral ischemia support the involvement of multiple biochemical pathways in the development of the isch
Externí odkaz:
https://doaj.org/article/79370d4aa0734d06b1a63ace24acd31d
Autor:
Hossein Azizi, Hamed Salmanzadeh, Robert F. Halliwell, Maryam Azadi, S. Mohammad Ahmadi-Soleimani
Publikováno v:
Current Neuropharmacology. 19:1560-1569
Adolescence is the transitional period between childhood and adulthood and a critical period in brain development. Adolescence in humans is also associated with increased expression of risk-taking behaviors. Epidemiological and clinical studies, for
Autor:
Rajkumar J. Sevak, Celine Chandler, May C. Lui, Adam M. Kaye, Robert F. Halliwell, Edward L. Rogan
Publikováno v:
American Journal of Pharmaceutical Education. :100125
Autor:
Maryam Azadi, Narges Pachenari, Robert F. Halliwell, Hossein Azizi, S. Mohammad Ahmadi-Soleimani, Tiziana Rubino, Hamed Salmanzadeh
Over the past decade, many studies have indicated that adolescence is a critical period of brain development and maturation. The refinement and maturation of the central nervous system over this prolonged period, however, makes the adolescent brain h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb8ac2145e02b4db34a604405b72e0b8
http://hdl.handle.net/11383/2086463
http://hdl.handle.net/11383/2086463
Publikováno v:
Toxicology in Vitro. 29:592-599
Determination of the impact of a drug on human brain development relies instead on surrogate animal studies. Here we have exploited the human stem cell line, TERA2.cl.SP12 to differentiate into neurons and addressed their value as an in vitro model t
Autor:
Robert F. Halliwell, John M. Haynes
Publikováno v:
Neurochemistry international. 106
Autor:
Robert F. Halliwell
Publikováno v:
Neurochemistry international. 106
Functional studies of neurons have traditionally used nervous system tissues from a variety of non-human vertebrate and invertebrate species, even when the focus of much of this research has been directed at understanding human brain function. Over t