Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Robert F. Ashman"'
Publikováno v:
International Immunology. 23:203-214
Toll-like receptor (TLR)9 performs our innate response to bacterial DNA, warning us of the presence of infection. Inhibitory oligodeoxyribonucleotides (INH-ODN) have been developed that selectively block activation of mouse TLR9. Their inhibitory mot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad935f9aab246111fd19ee8f2f13f3af
https://doi.org/10.1093/intimm/dxq473
https://doi.org/10.1093/intimm/dxq473
Autor:
Petar Lenert, Robert F. Ashman
Publikováno v:
Immunologic Research. 39:4-14
Synthetic oligodeoxyribonucleotides (ODN) bearing certain sequence characteristics mimic bacterial DNA by activating B cells and dendritic cells through Toll-like receptor (TLR) 9, an event that potentiates both humoral and cell-mediated immunity. OD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f6009f5320c458ccdaedcfbe3965433
https://doi.org/10.1007/s12026-007-0065-4
https://doi.org/10.1007/s12026-007-0065-4
Publikováno v:
Immunology. 117:474-481
Synthetic type B phosphorothioate oligodeoxyribonucleotides (ODN) activate mouse B cells via Toll-like receptor 9 (TLR9). Starting with closely related 15-mer prototype ODN, the sequence requirements for stimulatory (ST-) and inhibitory (IN-) activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b51dc6dcef30fcdafb3756fd2efd113d
https://doi.org/10.1111/j.1365-2567.2006.02320.x
https://doi.org/10.1111/j.1365-2567.2006.02320.x
Publikováno v:
Journal of Clinical Immunology. 25:29-40
Bacterial DNA triggers B-cell proliferation and induces immunoglobulin secretion. Chromatin-IgG complexes activate autoreactive B cells by co-engaging B-cell receptor (BCR) and TLR-9, thus suggesting a role for innate signaling in systemic autoimmuni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93438b66ad19da545737cab011533723
https://doi.org/10.1007/s10875-005-0355-6
https://doi.org/10.1007/s10875-005-0355-6
Publikováno v:
Journal of Clinical Immunology. 23:202-213
Inadequate immune response to infectious danger may contribute to the pathogenesis of systemic autoimmune diseases, e.g., systemic lupus erythematosus. To test this hypothesis, we studied innate responses of prediseased lupus-prone Palmerston North (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3af68505d84d2ba93e1db60ba8ebf1fd
https://doi.org/10.1023/a:1023361912950
https://doi.org/10.1023/a:1023361912950
Publikováno v:
International Immunology. 13:285-295
In the classic 'two-signal' model for B cell activation, signal 1 through the antigen receptor plus signal 2 through lymphokine receptors and CD40 leads to proliferation, but signal 1 alone leads to tolerance or anergy. In a protocol designed to deli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3979e14c897a1fd995709384d65adb05
https://doi.org/10.1093/intimm/13.3.285
https://doi.org/10.1093/intimm/13.3.285
Publikováno v:
International Immunology. 6:1777-1784
We have examined the role in B cell activation of ornithine decarboxylase (ODC), the labile rate-limiting enzyme in the synthesis of polyamines thought to be required for S phase entry in all cells. When small resting mouse splenic B cells were stimu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e920e350445ee0bfcebf4527fd007a2
https://doi.org/10.1093/intimm/6.11.1777
https://doi.org/10.1093/intimm/6.11.1777
Toll-like receptor 9 (TLR9) is an endosomal DNA sensor that warns us of the presence of infectious danger and triggers a rapid pro-inflammatory response in dendritic cells, macrophages, and B cells. The consequences of uncontrolled TLR9 activation ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf203b3648dc0426cc864845cb9c882b
https://europepmc.org/articles/PMC3119753/
https://europepmc.org/articles/PMC3119753/
Autor:
Radhika S. Ratnabalasuriar, Ann Marshak-Rothstein, Petar Lenert, Courtney J. Fleenor, Robert F. Ashman
Publikováno v:
The FASEB Journal. 22
Multiple lines of evidence suggest a role for nucleic-acid sensing receptors in the pathogenesis of SLE. Strategies to preferentially block autoimmune B cells may be preferred over currently advocated non-selective B cell depletion protocols. We have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7dc56416527e218a56d3dfa9eab2a9af
https://doi.org/10.1096/fasebj.22.1_supplement.1074.22
https://doi.org/10.1096/fasebj.22.1_supplement.1074.22
Publikováno v:
International immunology. 17(4)
Inhibitory oligonucleotides (IN-ODN) differing from stimulatory CpG ODN (ST-ODN) by as few as two bases can block ST-ODN-induced proliferation, apoptosis protection and IL-6 secretion in B lymphocytes and the production of IL-12p40 by non-B cells. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37d868386fd492e63fda62aac17b2ceb
https://pubmed.ncbi.nlm.nih.gov/15746247
https://pubmed.ncbi.nlm.nih.gov/15746247