Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Robert F Spiera"'
Autor:
John H Stone, Peter C Grayson, Ulrich Specks, E William St Clair, Peter A Merkel, Philip Seo, Carol A Langford, Paul A Monach, Cees G M Kallenberg, Robert F Spiera, Fernando C Fervenza, Zuoming Deng, Wei Tew, Marta Casal Moura, Stephen R Brooks, Marco Prunotto
Publikováno v:
RMD Open, Vol 9, Iss 1 (2023)
Background The frequency of proteinase 3 gene (PRTN3) polymorphisms in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is not fully characterised. We hypothesise that the presence of a PRTN3 gene polymorphism (sin
Externí odkaz:
https://doaj.org/article/6bc5f2edf8284a2885c3e9a25bbce574
Autor:
Karima Becetti, Joseph T. Nguyen, Linda Kwakkenbos, Marie‐Eve Carrier, Lydia Tao, Jessica K. Gordon, Carol A. Mancuso, Joep Welling, Luc Mouthon, Susan J. Bartlett, Vanessa L. Malcarne, Brett D. Thombs, Robert F. Spiera, Scleroderma Patient‐Centered Intervention Network Investigators
Publikováno v:
ACR Open Rheumatology, Vol 4, Iss 8, Pp 647-657 (2022)
Objective Systemic sclerosis (SSc) has significant psychosocial implications. We aimed to evaluate the proportion of participants in a large international SSc cohort who used mental health services in a 3‐month period and to evaluate demographic, p
Externí odkaz:
https://doaj.org/article/8ae0f0a94aa44ac3adaca03eb1ac8bb5
Autor:
Irena Doubelt, David Cuthbertson, Simon Carette, Sharon A. Chung, Lindsy J. Forbess, Nader A. Khalidi, Curry L. Koening, Carol Langford, Carol A. McAlear, Larry W. Moreland, Paul A. Monach, Philip Seo, Ulrich Specks, Robert F. Spiera, Jason M. Springer, Antoine G. Sreih, Kenneth J. Warrington, Peter A. Merkel, Christian Pagnoux, the Vasculitis Clinical Research Consortium
Publikováno v:
ACR Open Rheumatology, Vol 3, Iss 6, Pp 404-412 (2021)
Objective To describe clinical manifestations and outcomes in patients with eosinophilic granulomatosis with polyangiitis (EGPA) in North America. Methods Analysis of patients aged 18 years or older who fulfilled the 1990 American College of Rheumato
Externí odkaz:
https://doaj.org/article/82128a1fdc6e4dcaa4108c0e269815ce
Autor:
Peter A. Merkel, John Niles, Richard Jimenez, Robert F. Spiera, Brad H. Rovin, Andrew Bomback, Christian Pagnoux, Antonia Potarca, Thomas J. Schall, Pirow Bekker, for the CLASSIC Investigators
Publikováno v:
ACR Open Rheumatology, Vol 2, Iss 11, Pp 662-671 (2020)
Objective This study aimed to evaluate the safety of avacopan, an orally administered C5a receptor inhibitor, for the treatment of antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis in addition to standard‐of‐care (SOC) treatment
Externí odkaz:
https://doaj.org/article/bb81072b122a4bb88073ca8840742823
Autor:
Alvise Berti, Sophie Hillion, Amber M. Hummel, Young Min Son, Nedra Chriti, Tobias Peikert, Eva M. Carmona, Wayel H. Abdulahad, Peter Heeringa, Kristina M. Harris, E. William St. Clair, Paul Brunetta, Fernando C. Fervenza, Carol A. Langford, Cees G.M. Kallenberg, Peter A. Merkel, Paul A. Monach, Philip Seo, Robert F. Spiera, John H. Stone, Guido Grandi, Jie Sun, Jacques-Olivier Pers, Ulrich Specks, Divi Cornec, for the RAVE-ITN Research Group
Publikováno v:
JCI Insight, Vol 6, Iss 22 (2021)
BACKGROUND Little is known about the autoreactive B cells in antineutrophil cytoplasmic antibody–associated (ANCA-associated) vasculitis (AAV). We aimed to investigate tolerance checkpoints of circulating antigen-specific proteinase 3–reactive (P
Externí odkaz:
https://doaj.org/article/17108e393aed484eae0eb4f26d7643a8
Autor:
Alvise Berti, Sophie Hillion, Maximilian F. Konig, Marta Casal Moura, Amber M. Hummel, Eva Carmona, Tobias Peikert, Fernando C. Fervenza, Cees G.M. Kallenberg, Carol A. Langford, Peter A. Merkel, Paul A. Monach, Philip Seo, Robert F. Spiera, Paul Brunetta, E. William St. Clair, Kristina M. Harris, John H. Stone, Guido Grandi, Jacques‐Olivier Pers, Ulrich Specks, Divi Cornec
Publikováno v:
Arthritis & Rheumatology. 75:736-747
Autor:
Marta Casal, Moura, Gwen E, Thompson, Darlene R, Nelson, Lynn A, Fussner, Amber M, Hummel, Dieter E, Jenne, Daniel, Emerling, Fernando C, Fervenza, Cees G M, Kallenberg, Carol A, Langford, W Joseph, McCune, Peter A, Merkel, Paul A, Monach, Philip, Seo, Robert F, Spiera, E William, St Clair, Steven R, Ytterberg, John H, Stone, William H, Robinson, Ulrich, Specks
Publikováno v:
Arthritis & Rheumatology. 75:748-759
Proteinase 3 (PR3) is the major antigen for anti-neutrophil cytoplasmic antibodies (ANCAs) in the systemic autoimmune vasculitis, granulomatosis with polyangiitis (GPA). PR3 anti-neutrophil cytoplasmic antibodies (PR3-ANCAs) recognize different epito
Autor:
Gwen E. Thompson, Lynn A. Fussner, Amber M. Hummel, Darrell R. Schroeder, Francisco Silva, Melissa R. Snyder, Carol A. Langford, Peter A. Merkel, Paul A. Monach, Philip Seo, Robert F. Spiera, E. William St. Clair, John H. Stone, Ulrich Specks
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Background: The utility of ANCA testing as an indicator of disease activity in ANCA-associated vasculitis (AAV) remains controversial. This study aimed to determine the association of ANCA testing by various methods and subsequent remission and exami
Externí odkaz:
https://doaj.org/article/5b2b451663a14cfb8d37666f6f1c8cbf
Autor:
Sebastian E Sattui, Deanna Jannat-Khah, Lindsay Lally, Sarah B Lieber, Lisa A Mandl, Robert F Spiera
Publikováno v:
Rheumatology (Oxford)
Objective To describe the prevalence of frailty in a single-centre cohort of patients with PMR and describe its association with health-related quality of life (HRQoL), cognition and sarcopenia. Methods This was a cross-sectional study of patients wi
Autor:
Alvise, Berti, Sophie, Hillion, Maximilian F, Konig, Marta, Casal Moura, Amber M, Hummel, Eva, Carmona, Tobias, Peikert, Fernando C, Fervenza, Cees G M, Kallenberg, Carol A, Langford, Peter A, Merkel, Paul A, Monach, Philip, Seo, Robert F, Spiera, Paul, Brunetta, E William, St Clair, Kristina M, Harris, John H, Stone, Guido, Grandi, Jacques-Olivier, Pers, Ulrich, Specks, Divi, Cornec
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.).
Autoreactive B cells are responsible for ANCA production in ANCA-associated vasculitis (AAV). Rituximab depletes circulating B cells including autoreactive ones. We aimed to evaluate changes and associations with relapse of the circulating autoreacti