Zobrazeno 1 - 10
of 403
pro vyhledávání: '"Robert F Murphy"'
Autor:
Danielle J Clark, Laura E McMillan, Sin Lih Tan, Gaia Bellomo, Clementine Massoue, Harry Thompson, Lidiya Mykhaylechko, Dominic Alibhai, Xiongtao Ruan, Kentner L Singleton, Minna Du, Alan Hedges, Pamela L Schwartzberg, Paul Verkade, Robert F Murphy, Christoph Wülfing
Publikováno v:
eLife, Vol 8 (2019)
Supramolecular signaling assemblies are of interest for their unique signaling properties. A µm scale signaling assembly, the central supramolecular signaling cluster (cSMAC), forms at the center of the interface of T cells activated by antigen-pres
Externí odkaz:
https://doaj.org/article/6c4f2dbdb6a24ac88d4cbc5f40b47ea3
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 1, p e1006199 (2019)
Within influenza virus infected cells, viral genomic RNA are selectively packed into progeny virions, which predominantly contain a single copy of 8 viral RNA segments. Intersegmental RNA-RNA interactions are thought to mediate selective packaging of
Externí odkaz:
https://doaj.org/article/514afca17f8b4dc8a6b58a3d01b66bb2
Autor:
Rory M Donovan, Jose-Juan Tapia, Devin P Sullivan, James R Faeder, Robert F Murphy, Markus Dittrich, Daniel M Zuckerman
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 2, p e1004611 (2016)
The long-term goal of connecting scales in biological simulation can be facilitated by scale-agnostic methods. We demonstrate that the weighted ensemble (WE) strategy, initially developed for molecular simulations, applies effectively to spatially re
Externí odkaz:
https://doaj.org/article/bbda9059055246b793637190efdae397
Publikováno v:
eLife, Vol 5 (2016)
High throughput screening determines the effects of many conditions on a given biological target. Currently, to estimate the effects of those conditions on other targets requires either strong modeling assumptions (e.g. similarities among targets) or
Externí odkaz:
https://doaj.org/article/439eb7295a37486994856f01fbf3a7a3
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 12, p e1004614 (2015)
Characterizing the spatial distribution of proteins directly from microscopy images is a difficult problem with numerous applications in cell biology (e.g. identifying motor-related proteins) and clinical research (e.g. identification of cancer bioma
Externí odkaz:
https://doaj.org/article/086b698cbd1342e0a85c67905db0bb51
Autor:
Sebastian Weber, María L Fernández-Cachón, Juliana M Nascimento, Steffen Knauer, Barbara Offermann, Robert F Murphy, Melanie Boerries, Hauke Busch
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56690 (2013)
Detection of neuronal cell differentiation is essential to study cell fate decisions under various stimuli and/or environmental conditions. Many tools exist that quantify differentiation by neurite length measurements of single cells. However, quanti
Externí odkaz:
https://doaj.org/article/8159bde366b948aaa47c6682d638fa61
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83996 (2013)
High throughput and high content screening involve determination of the effect of many compounds on a given target. As currently practiced, screening for each new target typically makes little use of information from screens of prior targets. Further
Externí odkaz:
https://doaj.org/article/91ac33ee82994959baa042a23081ef51
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50292 (2012)
Microtubules are filamentous structures that are involved in several important cellular processes, including cell division, cellular structure and mechanics, and intracellular transportation. Little is known about potential differences in microtubule
Externí odkaz:
https://doaj.org/article/6789740c07f041599096f0cf1f8edbbf
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50514 (2012)
The Human Protein Atlas contains immunofluorescence images showing subcellular locations for thousands of proteins. These are currently annotated by visual inspection. In this paper, we describe automated approaches to analyze the images and their us
Externí odkaz:
https://doaj.org/article/d8927dd0e7a442fba3ca712883cd90ce
Autor:
Jiahe Lu, Alisa Veler, Boris Simonetti, Timsse Raj, Po Han Chou, Stephen J. Cross, Alexander M. Phillips, Xiongtao Ruan, Lan Huynh, Andrew W. Dowsey, Dingwei Ye, Robert F. Murphy, Paul Verkade, Peter J. Cullen, Christoph Wülfing
Publikováno v:
Cells, Vol 12, Iss 21, p 2558 (2023)
T cells can express multiple inhibitory receptors. Upon induction of T cell exhaustion in response to a persistent antigen, prominently in the anti-tumor immune response, many are expressed simultaneously. Key inhibitory receptors are CTLA-4, PD-1, L
Externí odkaz:
https://doaj.org/article/ac243134714943f4b979a7673d47dd5c