Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Robert F Hillary"'
Autor:
Danni A Gadd, Robert F Hillary, Daniel L McCartney, Shaza B Zaghlool, Anna J Stevenson, Yipeng Cheng, Chloe Fawns-Ritchie, Cliff Nangle, Archie Campbell, Robin Flaig, Sarah E Harris, Rosie M Walker, Liu Shi, Elliot M Tucker-Drob, Christian Gieger, Annette Peters, Melanie Waldenberger, Johannes Graumann, Allan F McRae, Ian J Deary, David J Porteous, Caroline Hayward, Peter M Visscher, Simon R Cox, Kathryn L Evans, Andrew M McIntosh, Karsten Suhre, Riccardo E Marioni
Publikováno v:
eLife, Vol 12 (2023)
Externí odkaz:
https://doaj.org/article/49877892abd24e60be24474ec13ce578
Autor:
Robert F Hillary, Daniel L McCartney, Hannah M Smith, Elena Bernabeu, Danni A Gadd, Aleksandra D Chybowska, Yipeng Cheng, Lee Murphy, Nicola Wrobel, Archie Campbell, Rosie M Walker, Caroline Hayward, Kathryn L Evans, Andrew M McIntosh, Riccardo E Marioni
Publikováno v:
PLoS Medicine, Vol 20, Iss 7, p e1004247 (2023)
BackgroundDNA methylation is a dynamic epigenetic mechanism that occurs at cytosine-phosphate-guanine dinucleotide (CpG) sites. Epigenome-wide association studies (EWAS) investigate the strength of association between methylation at individual CpG si
Externí odkaz:
https://doaj.org/article/f0b1e6cceb97419e8873e65cb9b0489b
Autor:
Danni A Gadd, Robert F Hillary, Robert I McGeachan, Sarah E Harris, Daniel L McCartney, N Joan Abbott, Roy A Sherwood, Riccardo E Marioni, Simon R Cox
Publikováno v:
Wellcome Open Research, Vol 6 (2022)
Background: Circulating S100 calcium-binding protein (S100β) is a marker of brain inflammation that has been associated with a range of neurological conditions. To provide insight into the molecular regulation of S100β and its potential causal asso
Externí odkaz:
https://doaj.org/article/aba8554a710746e786e0ab5bcd2d66ec
Autor:
Danni A Gadd, Robert F Hillary, Daniel L McCartney, Shaza B Zaghlool, Anna J Stevenson, Yipeng Cheng, Chloe Fawns-Ritchie, Cliff Nangle, Archie Campbell, Robin Flaig, Sarah E Harris, Rosie M Walker, Liu Shi, Elliot M Tucker-Drob, Christian Gieger, Annette Peters, Melanie Waldenberger, Johannes Graumann, Allan F McRae, Ian J Deary, David J Porteous, Caroline Hayward, Peter M Visscher, Simon R Cox, Kathryn L Evans, Andrew M McIntosh, Karsten Suhre, Riccardo E Marioni
Publikováno v:
eLife, Vol 11 (2022)
Protein biomarkers have been identified across many age-related morbidities. However, characterising epigenetic influences could further inform disease predictions. Here, we leverage epigenome-wide data to study links between the DNA methylation (DNA
Externí odkaz:
https://doaj.org/article/97b5228535ef4e2596046a3a97ea7f67
Autor:
Danni A Gadd, Robert F Hillary, Robert I McGeachan, Sarah E Harris, Daniel L McCartney, N Joan Abbott, Roy A Sherwood, Riccardo E Marioni, Simon R Cox
Publikováno v:
Wellcome Open Research, Vol 6 (2021)
Background: Circulating S100 calcium-binding protein (S100β) is a marker of brain inflammation that has been associated with a range of neurological conditions. To provide insight into the molecular regulation of S100β and its potential causal asso
Externí odkaz:
https://doaj.org/article/47dd8428cea1470e8f25fd8c9a58b659
Autor:
Jude Gibson, Tom C Russ, Toni-Kim Clarke, David M Howard, Robert F Hillary, Kathryn L Evans, Rosie M Walker, Mairead L Bermingham, Stewart W Morris, Archie Campbell, Caroline Hayward, Alison D Murray, David J Porteous, Steve Horvath, Ake T Lu, Andrew M McIntosh, Heather C Whalley, Riccardo E Marioni
Publikováno v:
PLoS Genetics, Vol 15, Iss 11, p e1008104 (2019)
'Epigenetic age acceleration' is a valuable biomarker of ageing, predictive of morbidity and mortality, but for which the underlying biological mechanisms are not well established. Two commonly used measures, derived from DNA methylation, are Horvath
Externí odkaz:
https://doaj.org/article/a3ae5f4eb91544119f3e3c5d7fd25cbe
Autor:
Danni A. Gadd, Robert F. Hillary, Daniel L. McCartney, Liu Shi, Aleks Stolicyn, Neil A. Robertson, Rosie M. Walker, Robert I. McGeachan, Archie Campbell, Shen Xueyi, Miruna C. Barbu, Claire Green, Stewart W. Morris, Mathew A. Harris, Ellen V. Backhouse, Joanna M. Wardlaw, J. Douglas Steele, Diego A. Oyarzún, Graciela Muniz-Terrera, Craig Ritchie, Alejo Nevado-Holgado, Tamir Chandra, Caroline Hayward, Kathryn L. Evans, David J. Porteous, Simon R. Cox, Heather C. Whalley, Andrew M. McIntosh, Riccardo E. Marioni
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Characterising associations between the methylome, proteome and phenome may provide insight into biological pathways governing brain health. Here, blood protein markers of brain health are integrated with omics data to reveal DNA methylation differen
Externí odkaz:
https://doaj.org/article/1eaa7fc6efbf4260a056871f0b0cae03
Autor:
Robert F. Hillary, Daniel Trejo-Banos, Athanasios Kousathanas, Daniel L. McCartney, Sarah E. Harris, Anna J. Stevenson, Marion Patxot, Sven Erik Ojavee, Qian Zhang, David C. Liewald, Craig W. Ritchie, Kathryn L. Evans, Elliot M. Tucker-Drob, Naomi R. Wray, Allan F. McRae, Peter M. Visscher, Ian J. Deary, Matthew R. Robinson, Riccardo E. Marioni
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-15 (2020)
Abstract Background The molecular factors which control circulating levels of inflammatory proteins are not well understood. Furthermore, association studies between molecular probes and human traits are often performed by linear model-based methods
Externí odkaz:
https://doaj.org/article/19534d9a8ec84e659ab1448d4b67f986
Autor:
Robert F. Hillary, Una FitzGerald
Publikováno v:
Journal of Biomedical Science, Vol 25, Iss 1, Pp 1-10 (2018)
Abstract Background Activating transcription factor 6 (ATF6) is an endoplasmic reticulum (ER)-localised protein and member of the leucine zipper family of transcription factors. Best known for its role in transducing signals linked to stress to the e
Externí odkaz:
https://doaj.org/article/67059f589a6549b3aec16677ad81752c
Autor:
Danni A. Gadd, Robert F. Hillary, Zhana Kuncheva, Tasos Mangelis, Romi Admanit, Jake Gagnon, Tinchi Lin, Kyle Ferber, Heiko Runz, Biogen Biobank Team, Riccardo E. Marioni, Christopher N. Foley, Benjamin B. Sun
The circulating proteome offers insights into the biological pathways that underlie disease. Here, we test relationships between 1,468 Olink protein levels and the incidence of 23 age-related diseases and mortality, ascertained over 16 years of elect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::089fe651223267ab44d46e701f8c7009
https://doi.org/10.1101/2023.05.01.23288879
https://doi.org/10.1101/2023.05.01.23288879
