Zobrazeno 1 - 10
of 386
pro vyhledávání: '"Robert F, Siliciano"'
Autor:
Ellie Mainou, Stella J. Berendam, Veronica Obregon-Perko, Emilie A. Uffman, Caroline T. Phan, George M. Shaw, Katharine J. Bar, Mithra R. Kumar, Emily J. Fray, Janet M. Siliciano, Robert F. Siliciano, Guido Silvestri, Sallie R. Permar, Genevieve G. Fouda, Janice McCarthy, Ann Chahroudi, Jessica M. Conway, Cliburn Chan
Publikováno v:
Epidemics, Vol 48, Iss , Pp 100780- (2024)
While the benefits of early antiretroviral therapy (ART) initiation in perinatally infected infants are well documented, early initiation is not always possible in postnatal pediatric HIV infections. The timing of ART initiation is likely to affect t
Externí odkaz:
https://doaj.org/article/60d2aef43b0643d1af9bb0c95351b590
Autor:
Natalie F. McMyn, Joseph Varriale, Emily J. Fray, Carolin Zitzmann, Hannah MacLeod, Jun Lai, Anushka Singhal, Milica Moskovljevic, Mauro A. Garcia, Brianna M. Lopez, Vivek Hariharan, Kyle Rhodehouse, Kenneth Lynn, Pablo Tebas, Karam Mounzer, Luis J. Montaner, Erika Benko, Colin Kovacs, Rebecca Hoh, Francesco R. Simonetti, Gregory M. Laird, Steven G. Deeks, Ruy M. Ribeiro, Alan S. Perelson, Robert F. Siliciano, Janet M. Siliciano
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 17 (2023)
HIV-1 persists in a latent reservoir in resting CD4+ T cells despite antiretroviral therapy (ART). The reservoir decays slowly over the first 7 years of ART (t1/2 = 44 months). However, whether decay continues with long-term ART is unclear. Recent in
Externí odkaz:
https://doaj.org/article/16cb14484f3b4a688aeb5fd64cf309ef
Autor:
Victoria E. K. Walker-Sperling, Noe B. Mercado, Abishek Chandrashekar, Erica N. Borducchi, Jinyan Liu, Joseph P. Nkolola, Mark Lewis, Jeffrey P. Murry, Yunling Yang, Romas Geleziunas, Merlin L. Robb, Nelson L. Michael, Maria G. Pau, Frank Wegmann, Hanneke Schuitemaker, Emily J. Fray, Mithra R. Kumar, Janet D. Siliciano, Robert F. Siliciano, Dan H. Barouch
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-8 (2022)
Antiretroviral therapy alone is insufficient in curing HIV-1 infection, due to latent viral reservoir persistency. Here, authors explore the post-virologic control of combining active and passive immunisation with vesatolimod, in a SHIV-infected rhes
Externí odkaz:
https://doaj.org/article/3d61c11904ca4bafb0acb1d4d9eb6212
Autor:
Jennifer A. White, Fengting Wu, Saif Yasin, Milica Moskovljevic, Joseph Varriale, Filippo Dragoni, Angelica Camilo-Contreras, Jiayi Duan, Mei Y. Zheng, Ndeh F. Tadzong, Heer B. Patel, Jeanelle Mae C. Quiambao, Kyle Rhodehouse, Hao Zhang, Jun Lai, Subul A. Beg, Michael Delannoy, Christin Kilcrease, Christopher J. Hoffmann, Sébastien Poulin, Frédéric Chano, Cécile Tremblay, Jerald Cherian, Patricia Barditch-Crovo, Natasha Chida, Richard D. Moore, Michael F. Summers, Robert F. Siliciano, Janet D. Siliciano, Francesco R. Simonetti
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 6 (2023)
Background Antiretroviral therapy (ART) halts HIV-1 replication, decreasing viremia to below the detection limit of clinical assays. However, some individuals experience persistent nonsuppressible viremia (NSV) originating from CD4+ T cell clones car
Externí odkaz:
https://doaj.org/article/ef49646c2a614ed590cf85b7b8881c2b
Autor:
John D. Ventura, Joseph P. Nkolola, Abishek Chandrashekar, Erica N. Borducchi, Jinyan Liu, Noe B. Mercado, David L. Hope, Victoria M. Giffin, Katherine McMahan, Romas Geleziunas, Jeffrey P. Murry, Yunling Yang, Mark G. Lewis, Maria G. Pau, Frank Wegmann, Hanneke Schuitemaker, Emily J. Fray, Mithra R. Kumar, Janet D. Siliciano, Robert F. Siliciano, Merlin L. Robb, Nelson L. Michael, Dan H. Barouch
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-8 (2022)
Abstract Developing an intervention that results in virologic control following discontinuation of antiretroviral therapy (ART) is a major objective of HIV-1 cure research. In this study, we investigated the therapeutic efficacy of a vaccine consisti
Externí odkaz:
https://doaj.org/article/e42cb38a5f4c44cdb752a66e3a3f759b
Autor:
Sarah E. Benner, Yolanda Eby, Xianming Zhu, Reinaldo E. Fernandez, Eshan U. Patel, Jessica E. Ruff, Feben Habtehyimer, Haley A. Schmidt, Charles S. Kirby, Sarah Hussain, Darin Ostrander, Niraj M. Desai, Sander Florman, Meenakshi M. Rana, Rachel Friedman-Moraco, Marcus R. Pereira, Shikha Mehta, Peter Stock, Alexander Gilbert, Michele I. Morris, Valentina Stosor, Sapna A. Mehta, Catherine B. Small, Karthik Ranganna, Carlos A.Q. Santos, Saima Aslam, Jennifer Husson, Maricar Malinis, Nahel Elias, Emily A. Blumberg, Brianna L. Doby, Allan B. Massie, Melissa L. Smith, Jonah Odim, Thomas C. Quinn, Gregory M. Laird, Robert F. Siliciano, Dorry L. Segev, Andrew D. Redd, Christine M. Durand, Aaron A.R. Tobian
Publikováno v:
JCI Insight, Vol 7, Iss 21 (2022)
The HIV latent viral reservoir (LVR) remains a major challenge in the effort to find a cure for HIV. There is interest in lymphocyte-depleting agents, used in solid organ and bone marrow transplantation to reduce the LVR. This study evaluated the LVR
Externí odkaz:
https://doaj.org/article/09d1623efd834d26a727f8f8faacd04a
Autor:
Jennifer A White, Joshua T Kufera, Niklas Bachmann, Weiwei Dai, Francesco R Simonetti, Ciara Armstrong, Jun Lai, Subul Beg, Janet D Siliciano, Robert F Siliciano
Publikováno v:
PLoS Pathogens, Vol 18, Iss 9, p e1010845 (2022)
Antiretroviral therapy (ART) effectively inhibits HIV-1 replication but is not curative due to the persistence of a latent viral reservoir in resting CD4+ T cells. This reservoir is a major barrier to cure. Sequencing studies have revealed that the p
Externí odkaz:
https://doaj.org/article/90c900152949401b8709754fb7fb5878
Autor:
Anthony M. Cadena, John D. Ventura, Peter Abbink, Erica N. Borducchi, Hubert Tuyishime, Noe B. Mercado, Victoria Walker-Sperling, Mazuba Siamatu, Po-Ting Liu, Abishek Chandrashekar, Joseph P. Nkolola, Katherine McMahan, Nicole Kordana, Venous Hamza, Esther A. Bondzie, Emily Fray, Mithra Kumar, Stephanie Fischinger, Sally A. Shin, Mark G. Lewis, Robert F. Siliciano, Galit Alter, Dan H. Barouch
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The existence of HIV reservoir and ongoing replication despite antiretroviral therapy (ART) represents a barrier for cure efforts. Here, using SIV/SHIV-infected rhesus macaque suppressed with ART for one year, the authors characterize multiple lympho
Externí odkaz:
https://doaj.org/article/202e143cd50c4ecea53a829693bdf039
Publikováno v:
Retrovirology, Vol 15, Iss 1, Pp 1-9 (2018)
Abstract Antiretroviral therapy cannot cure HIV-1 infection due to the persistence of a small number of latently infected cells harboring replication-competent proviruses. Measuring persistent HIV-1 is challenging, as it consists of a mosaic populati
Externí odkaz:
https://doaj.org/article/f2aadc92435048d68e15bc3e23417f08
Autor:
Brianna Lopez, Robert F. Siliciano
Publikováno v:
Trends in Immunology. 44:147-149
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62b8ac80eb629d727a2123a3c1876b26
https://doi.org/10.1016/j.it.2023.01.007
https://doi.org/10.1016/j.it.2023.01.007