Zobrazeno 1 - 10
of 200
pro vyhledávání: '"Robert F, Margolskee"'
Autor:
Cailu Lin, Masafumi Jyotaki, John Quinlan, Shan Feng, Minliang Zhou, Peihua Jiang, Ichiro Matsumoto, Liquan Huang, Yuzo Ninomiya, Robert F. Margolskee, Danielle R. Reed, Hong Wang
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106920- (2023)
Summary: T2R bitter receptors, encoded by Tas2r genes, are not only critical for bitter taste signal transduction but also important for defense against bacteria and parasites. However, little is known about whether and how Tas2r gene expression are
Externí odkaz:
https://doaj.org/article/8d75aff6df254e53916ac9c7eb02dc38
Autor:
Nanako Atsumi, Keiko Yasumatsu, Yuriko Takashina, Chiaki Ito, Norihisa Yasui, Robert F Margolskee, Atsuko Yamashita
Publikováno v:
eLife, Vol 12 (2023)
Salt taste sensation is multifaceted: NaCl at low or high concentrations is preferably or aversively perceived through distinct pathways. Cl− is thought to participate in taste sensation through an unknown mechanism. Here, we describe Cl− ion bin
Externí odkaz:
https://doaj.org/article/954be8e0867a40d6b47cae87bedcd584
Publikováno v:
PLoS Biology, Vol 21, Iss 1, p e3001647 (2023)
The oral microbiome is second only to its intestinal counterpart in diversity and abundance, but its effects on taste cells remains largely unexplored. Using single-cell RNASeq, we found that mouse taste cells, in particular, sweet and umami receptor
Externí odkaz:
https://doaj.org/article/56b24ee2f40c4e9d96385328b603d379
Autor:
Xin Zheng, Marco Tizzano, Kevin Redding, Jinzhi He, Xian Peng, Peihua Jiang, Xin Xu, Xuedong Zhou, Robert F. Margolskee
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Solitary chemosensory cells (SCCs) expressing taste receptors reside in mucosal epithelia including the gingiva. Here the authors show that ablation of taste-sensing by SSCs leads to outgrowth of pathogenic oral bacteria and periodontitis, whereas bi
Externí odkaz:
https://doaj.org/article/8caffc7909634deb85a1fda385dca1cc
Autor:
Paul A S Breslin, Akiko Izumi, Anilet Tharp, Tadahiro Ohkuri, Yoshiaki Yokoo, Linda J Flammer, Nancy E Rawson, Robert F Margolskee
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0256989 (2021)
The taste stimulus glucose comprises approximately half of the commercial sugar sweeteners used today, whether in the form of the di-saccharide sucrose (glucose-fructose) or half of high-fructose corn syrup (HFCS). Therefore, oral glucose has been pr
Externí odkaz:
https://doaj.org/article/63bb85e0136e4ad3a4549c53e793c81c
Autor:
Martina Donadoni, Rafal Kaminski, Shuren Liao, Suhair Al Janabi, Robert F. Margolskee, Mehmet Hakan Ozdener, Ilker K. Sariyer
Publikováno v:
Journal of NeuroVirology. 29:35-44
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cdcdb755de0a66e478a4b798d3de06a
https://doi.org/10.1007/s13365-023-01117-3
https://doi.org/10.1007/s13365-023-01117-3
Autor:
Sunil K. Sukumaran, Brian C. Lewandowski, Yumei Qin, Ramana Kotha, Alexander A. Bachmanov, Robert F. Margolskee
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Analysis of single-cell RNA-Seq data can provide insights into the specific functions of individual cell types that compose complex tissues. Here, we examined gene expression in two distinct subpopulations of mouse taste cells: Tas1r3-expres
Externí odkaz:
https://doaj.org/article/3a624e5a9e5546a8bc99e886b1acbef3
Transcriptome analyses of taste organoids reveal multiple pathways involved in taste cell generation
Autor:
Wenwen Ren, Eitaro Aihara, Weiwei Lei, Nishi Gheewala, Hironobu Uchiyama, Robert F. Margolskee, Ken Iwatsuki, Peihua Jiang
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Taste cells undergo constant turnover throughout life; however, the molecular mechanisms governing taste cell generation are not well understood. Using RNA-Seq, we systematically surveyed the transcriptome landscape of taste organoids at dif
Externí odkaz:
https://doaj.org/article/2b8eaf0b31324533849755c33c546893
Autor:
Shingo Takai, Yu Watanabe, Keisuke Sanematsu, Ryusuke Yoshida, Robert F Margolskee, Peihua Jiang, Ikiru Atsuta, Kiyoshi Koyano, Yuzo Ninomiya, Noriatsu Shigemura
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0225190 (2019)
Expression of insulin and its receptor (IR) in rodent taste cells has been proposed, but exactly which types of taste cells express IR and the function of insulin signaling in taste organ have yet to be determined. In this study, we analyzed expressi
Externí odkaz:
https://doaj.org/article/867b31370ad047b8845f279eb24b0d8f
Autor:
Cailu Lin, Masafumi Jyotaki, John Quinlan, Shan Feng, Minliang Zhou, Peihua Jiang, Ichiro Matsumoto, Liquan Huang, Yuzo Ninomiya, Robert F. Margolskee, Danielle R. Reed, Hong Wang
Publikováno v:
bioRxiv
SummaryT2R bitter receptors, encoded byTas2rgenes, are not only critical for bitter taste signal transduction but also important for defense against bacteria and parasites. However, little is known about whether and howTas2rgene expression are regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e98afe1ef4fdca1e291b675daf2887
https://doi.org/10.1101/2023.02.08.527520
https://doi.org/10.1101/2023.02.08.527520
